Laura Barron, Module 2 Acid-Base Disturbances - Brunners Ratio 20parts of HCO3- (Bicarbonate) : 1part H2CO3 (Carbonic Acid) CO2 is a potential Acid. When dissolved in water → H2CO3 Carbonic Acid Regulation by Kidney – Slow R Acidosis & most cases of M Acidosis: K. ↓ (excrete) H+ and ↑ (conserve) HCO3R & M Alkalosis ↑ H+ ↓ HCO3Kidney Failure M Acidosis cannot be compensated Regulation by Lungs – Control by Medulla O. M. Acidosis ↑ respiration ↓ CO2 M. Alkalosis ↓ respiration rate ↑ CO Acute and Chronic Metabolic Acidosis (Base Bicarbonate Deficit) ↓ pH and ↓ bicarb (allowing the high acidic value) Anion Gap Na+ + K+ - Cl- - HCO3- = Anion Gap Norm: 12-16mEq/L or 8-12 w/o K+ >16 acidosis (Normal anion gap) resulting from: loss of bicarbonate: diarrhea, lower intestinal fistulas, diuretics, early renal insufficiency, excess admin chloride, admin of nutrition w/o bicarbonate (lactate) = hyperchloremic acidosis. >30 metabolic acidosis regardless of pH and HCO3-. resulting from: ketoacidosis, lactic acidosis, salicylate poisoning, starvation. Negative gap is rare caused by hypoproteinemia. o s/s: Clinical manifestations – headache, confusion, drowsiness, increased resp rate/depth, N & V. Seen in Chronic Renal Failure. o Assessment and diagnostic Findings HCO3- < 22 ph<7.35 Hyperkalemia may occur, and then shift back into the cell after. Hyperventilation decreases CO2 – Compensatory action. o Medical Management – bicarbonate (low ca treated first from chronic met acidosis to avoid tetany) Acute and Chronic Metabolic Alkalosis (Base Bicarbonate Excess) Laura Barron, Module 2 high pH high bicarbonate. Vomiting, gastric suction. loss of potassium from diuretic. Excessive adrenocorticoid hormones, hypokalemia, excessive ingestion of antacids. o Clinical Manifestations – tingling of fingers and toes, dizziness, hypertonic muscles. Respirations depressed as compensatory action by lungs. tachycardia, decreased motility and paralytic ileus. as K+ decreases chronic met alk. has premature ventricular contractions or U waves on ECG. o Assessment and Diagnostic Findings – ph > 7.45, hco3- > 26mEq/L o Medical Management – monitor I/O because of fluid loss.IVF NS w/chloride allows binding with bicarb to excrete. Then any treatment of KCL Acute and Chronic Respiratory Acidosis (Carbonic Acid Excess) ph< 7.35, paCO2 > 42. Always due to inadequate excretion of CO2 – ventilation. Acute pulmonary edema, aspiration of a foreign object, Atelectasis, Pneumothorax, overdose of sedatives, sleep apnea syndrome, impaired respiratory muscles – mechanical ventilation. o Clinical Manifestations – increase pulse and respiratory rate, incr blood pressure, feeling of fullness in head, mental cloudiness. increased cerebral blood flow. Chronic – emphysema, bronchitis, obesity. COPD may not develop symptoms of Hypercapnia because of compensatory renal changes have occurred. o Assessment and Diagnostic Findings - ph< 7.35, paCO2 > 42, chest xray ECG o Medical Management – improve ventilation Bronchodilators, Antibiotics, Thrombolytics/anticoagulants. Pulmonary hygiene to clear resp tract of mucus. Adequate Hydration! O2 as necessary. Decrease elevated paCO2 slowly. Semi-Fowler’s position to expand chest wall. o pco2 > 50 chronically – O2 may cause carbon dioxide narcosis when removing the stimulus of hypoxemia. Extreme caution. Acute and Chronic Respiratory Alkalosis (Carbonic Acid Deficit) ph > 7.45 paco2 < 38. Always caused by Hyperventilation blowing of co2. causes extreme anxiety, hypoxemia, salicylate intoxication o Clinical Manifestations – light headedness Vaso Constriction, decreased cerebral blood flow. inability to concentrate, numbness and tingling from decreased calcium, tinnitus, LOC, Tachycardia, Dysrhythmia. o Assessment and Diagnostic Findings – Compensated state kidneys have lowered bicarb to near normal level. Toxicology screen should be performed to rule out salicylate intoxication. o Medical Management – if Anxiety. Breathe slowly to allow CO2 to accumulate or into paper bag. sedative. Mixed Acid-Base Disorders normal pH with changes in paco2 and hco3-. (Can’t have mixed R Acid & R Alka – you can’t hyper and hypo ventilate.) Met Acid and Resp Acid – during respiratory and cardiac Arrest. o Compensation – lungs and kidneys compensate to return the pH to normal. o Blood Gas Analysis –