Lesson 1: Intermolecular Forces Principles
Learning Objectives:
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Describe the effect of the strength of intermolecular forces on solubility
Describe the effect of the strength of intermolecular forces on sate of matter, boiling point
NJCCCS: 5.2.12.B.1
Anticipatory Set: A demonstration of water's intermolecular forces will be done- pepper flakes dropper
in water, which demonstrate the high surface tension of water due to hydrogen bonding. Students will
predict how and why it works.
Tech Use: Molecules in Jmol
Instructional Activities:
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Review HW on Intermolecular Forces, Review Packet
Driving Question: How does soap work? Students will brainstorm answers to this question.
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Introduction of "like dissolves like"- polar substances mix with polar OR ionic substances;
nonpolar substances mix with nonpolar
Nonpolar and Polar Substances Mixed
Discuss the functioning of soap, which contains hydrophilic and hydrophobic regions to dissolve
in water, but attract grease
Differences in boiling points of various compounds (i.e. H2O vs. H2S) will be discussedcompounds with stronger intermolecular forces have higher boiling points.
Online Activity- students will use the Jmol applets to investigate shapes and bond angles
Closure: The density of ice vs. water will be discussed and the ramifications of water's higher density
(i.e. lakes freezing from the top down)
Assessment Plan:
Unit 6 Test
Chromatography Lab
Lesson 2: Chromatography Lab Lesson
Learning Objectives:
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Separate components of ink using paper chromatography
Identify an unknown ink sample using chromatography
NJCCCS: 5.2.12.B.1
Anticipatory Set: Brainstorm the question- "How can substances dissolved in solution be separated?"
Students should use the principles discussed
Tech Use: none
Instructional Activities:
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Explain the principles of chromatography, which are based on solubility and polarity.
Analogy for Chromatography: A student who is chatty and “bonds” with other students along the
way (attracted to the stationary phase) vs. a diligent student on his/her way to class who does not
chat with others along the way gets through the hallway quickly (attracted to the mobile phase)
Ink Chromatography Lab- Students will use Paper chromatography to separate the components of
various black and green ink markers, relating polarity to the mobile/stationary phase of the
system. They will record observations, measure Rf values. Finally, they will use the
chromatograms to identify an unknown sample.
While waiting for the chromatograms to develop, students can try the pepper sinking demo, as
well as a "milk swirling" demo- in which soap acts as a surfactant to break up the fats and
proteins in milk.
Students will collect quantitative and qualitative data on their chromatograms.
Closure: Students will report their overall findings.
Assessment Plan:
Lab Report
(Day 3: Test)
Lesson 3: Intermolecular Forces in Biological Systems
Learning Objectives:
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Describe the role of intermolecular forces in protein folding, DNA, ligand binding
NJCCCS: 5.2.12.B.1
Anticipatory Set: Students will brainstorm some pharmaceutical products that they might be familiar
with-i.e. they may know aspirin is an analgesic, warfarin is an anticoagulant, penicilin is an antibiotic
Tech Use: Structures of DNA, Proteins
Instructional Activities:
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Importance of hydrogen bonding to protein folding (alpha helices, beta pleated sheets of
secondary structure)
Importance of H bonding to DNA double helix structure
Hydrophobicity of cell membrane- allows lipophilic molecules to enter cell
Hydrophilicity of blood stream- compounds either need to be water soluble or be carried by a
protein in the bloodstream (i.e. albumin, lipoproteins)
Driving Question: "How do receptors work?" Receptors found throughout the body bind ligands, which
set off other reactions that lead to biological functions. Molecules that mimic natural ligands can be used
as therapeutics.
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Example of IMFs shown
ChemMatters Article- Fighting Bacteria- discusses the functionality of the beta-lactam ring in
penicillin; this article relates drug structure to bond angles (the 109ºbond angle, the 120ºbond
angle in the carbonyl group)
Introduction of Mini-Project on Drug Interactions
Assessment Plan:
Drug Interactions Project (presentations)
Lesson 4 (Half Day)
Learning Objectives:
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Apply concepts of intermolecular bonding to drug design
NJCCCS: 5.2.12.B.1
Instructional Activities: Students will have time to brainstorm/research their projects on drug classes
Assessment Plan:
Drug Interactions Project (presentations)