Team Activity 9
Ken Amayo, Nataile John, Simone Autin, Hiral Patel, and Traci Benedict
In your Teams, prepare 3 multiple choice questions on the topic of Buffers and pH.
1. What is the range for buffer capacity?
A. 1-4
B. 0.01-0.25
C. 0.5-1
D. 0.24-0.5
2. What ratio will give the highest buffer capacity?
A. 1:2
B. 1:3
C. 1:1
D. 1:10
3. What is a buffer?
A. A weak acid and weak base
B. A weak acid and a conjugate base
C. A strong and a strong base
D. A weak base and a conjugate acid
In your Teams, prepare 3 multiple choice questions on the topic of Solubility.
1. What is the blend of solvents to increase the solubility of a given drug?
A. Iso-osmotic
B. Iso-tonic
C. Co-solvents
D. Buffers
2. The pH and the pKa are the only factors that determine the ratio of acid and base are present.
A. True
B. False
3. Which of the following will affect solubility?
A. Molecular size
B. Molecular shape
C. Position
D. All of the above
In your Teams, list 5 drugs from your “Top 200 Prescription Drug List” from PHA 371 – Practice of
Pharmacy that are weak acids and 5 drugs from this list that are weak bases. Identify the weak acid or
weak base functional group in each molecule.
Methotrexate is a weak acid and contains 2 carboxylic acid groups
Warfarin is a weak acid and contains a terminal carboxylic acid
Prednisolone Sodium Phosphate is a weak acid and contains carboxylic acid groups
Furosemide is a weak acid because it contains a carboxylic acid
Folic acid is a weak acid it contains carboxylic acid groups
Diazepam is a weak base because contains Chloride groups accept protons
Dextroamphetamine (Adderall) is a weak base and contains a terminal amine group
Risperidone is a weak base because it contains multiple amine groups
Xanax is a weak base, it contains Chloride groups accept protons
Norvasc is a weak base because contains Chloride groups accept protons