Team Activity 9
In your Teams, prepare 3 multiple choice questions on the topic of Buffers and pH.
1. Which of the following is a true statement:
A. For a buffer with [A-] > [HA], Ka < [H+]
B. For a buffer with [A-] > [HA], Ka > [H+]
C. A buffer is more effective when [A-] > [HA]
D. A buffer is less effective when [A-] < [HA]
2. Choose the best order of tasks from first to last to use in creating a buffer solution:
A. select an acid, Use the Van Slyke equation, calculate molar amounts, use the Henderson
Hasselbach equation, calculate ratio of base to acid
B. calculate molar amounts, calculate ratio of base to acid, select an acid, use the
Henderson Hasselbach equation, Use the Van Slyke equation
C. select an acid, calculate the ratio of base to acid, Use the Henderson Hasselbach
equation, Use the Van Slyke equation, calculate molar amounts
D. calculate molar amounts, select an acid, calculate ratio of base to acid, Use the Van
Slyke equation, Use the Henderson Hasselbach equation
3. If the pKa of an acid is 4.5, which compound would serve as the best buffer solution?
A. Citric acid, pKa=6.4
B. Phosphoric Acid, pKa=12.7
C. Acetic Acid, pKa=5.1
D. Hydrochloric Acid, pKa=2.5
In your Teams, prepare 3 multiple choice questions on the topic of Solubility.
1. True or False: An increase in pH shifts the solubility to form more A2. Which factors affect the solubility of a drug
A.
The surface area of the drug
B. pH of the solution
C. The form of the drug (ionized or unionized)
D. A and C
E. all of the above
3. When protein is placed in a sodium chloride solution and the protein precipitates out, this
action is called:
A. Salting out
B. Salting in
C. No reaction occurs
D. Common Ion Effect
In your Teams, list 5 drugs from your “Top 200 Prescription Drug List” from PHA 371 – Practice
of Pharmacy that are weak acids and 5 drugs from this list that are weak bases. Identify the
weak acid or weak base functional group in each molecule.
Weak acids
1. Levothyroxine Sodium - this is the salt form but the acid is carboxylic acid
2. Naproxen - carboxylic acid
3. Fexofenadine Hydrochloride - carboxylic acid
4. Albuterol Sulfate - phenol
5. Montelukast Sodium - this is the salt form but the acid is carboxylic acid
Weak bases
1. Omeprazole (Prilosec) – pyridine
2. Metoprolol Succinate (Toprol-XL) – secondary amine
3. Cyclobenzaprine HCl (Amrix, Flexeril, Fexmid) – tertiary amine
4. Amitryiptyline HCl (Elavil) – tertiary amine
5. Hydrocodone Bitartrate w/ Acetaminophen (Lortab, Vicodin, Lorcet, Norco) – tertiary
amine