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ABSTRACT
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REFERENCES
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- EXAMPLE TOWARDS A “SURFACE SCIENCE MODEL FOR BIOLOGY”:
GLYCINE ADSORPTION ON NANOHYDROXYAPATITE WITH
WELL DEFINED SURFACES
Albert Rimola,a,b Yuriy Sakhno,a Marco Lelli,c Salvatore Coluccia,a Piero Ugliengo,a
Gianmario Martraa (gianmario.martra@unito.it)
a)Dipartimento di Chimica & NIS Center of Excellence, Università di Torino, Via P. Giuria 7,
10125, Torino, Italy. b)Departmento de Química, Universitat Autònoma de Barcelona, 08193,
Bellaterra, Spain. c)Dipartimento di Chimica “G. Ciamician”, Università di Bologna, Via Selmi 2,
40126, Bologna, Italy
ABSTRACT
Hydroxyapatite (HA), [Ca10(PO4)6(OH)2], the natural major inorganic constituent of bone and
teeth in the form of nano-crystals, is usually a system of choice to study protein/biocompatiblesurface interactions. The study of these interactions is crucial not only for the development of new
biomaterials and to understand biomineralization processes but also for several technological and
biomedical applications such as biodevices and drug delivery systems. Nonetheless, despite the
great efforts in investigating protein/HA systems, atomistic information on the actual contact
occurring at the interface is rather scarce. Suitable to this target is the adoption of a “surface
science model” approach, based on the interplay among the preparation of materials with well
defined surface features, spectroscopic and accurate quantum mechanical techniques. This
approach has been very fruitful to obtain a deep knowledge on surface molecular events relevant
for heterogeneous catalysis, hence successfully developing a well-established “surface science
model for catalysis”. In that respect, it is worth pointing out that for the model to be successful,
extended non-defective crystalline faces grown out of a single crystal are usually employed,
together with ultra high vacuum conditions. At variance with this approach, here we worked at
standard conditions and focused on the possibility to employ nanometric HA particles with well
defined surfaces, because in bone tissues, HA is present as nanoparticles embedded in a collagen
matrix, to form a highly organized composite material and not as a bulk extended crystal.
These HA nanoparticles were used to
investigate the adsorption of non-ionic
HOOC-CH2-NH2
glycine
(Gly)
vapours
by means of IR
measurements. The adoption of a
single aminoacid, as the basic
molecular brick of proteins, has
allowed
to
supplement
the
experimental
measurements
with
modelling techniques (Figure 1) based
on first principle quantum mechanical
methods which have been successfully
adopted in the past by some of us.
Details and relevant literature are in ref
[1].
Figure 1. Experimental (green line) and
calculated (red line) spectra of Gly adsorbed on
nanohydroxyapatite, mainly exposing (010) surfaces
REFERENCES
[1]
A. Rimola, Yu. Sakhno, L. Bertinetti, M. Lelli, G. Martra, and P. Ugliengo, J. Phys. Chem. Lett.,
2 ( 2011) 1390-1394.