Bases of toxicological chemistry and chemical-toxicological analysis. CTA "metal" and "volatile"
poisons
1. The acidity of urine or stomach medium is determined by universal indicator paper. Which is
the medium acidity at poisoning by alkali metal carbonate?
A. pH = 1 ... 2
B. pH = 12 ... 13
C. pH = 7 ... 8
D. pH = 2 ... 3
E. pH = 3 ... 4
ANSWER: C
2. Different indicator papers are used in preliminary test. If indicator paper moistened by lead
acetate became black so ….. is presence in biological objects:
A. hydrogen chloride
B. hydrogen sulfide
C. sulfuric acid
D. sodium hydroxide
E. ammonium hydroxide
ANSWER: B
3. The gastric contents painted blue. Which salt is cause of this color?
A. sodium sulfate
B. copper sulfate
C. mercury sulfate
D. ammonium sulfate
E. zinc sulfate
ANSWER: B
4. Whicg substance you may use for conservation objects of chemical and toxicological analysis?
A. methanol
B. ethanol
C. formaldehyde
D. phenol
E. acetone
ANSWER: B
5. The contents of the stomach painted in black colour. The presence of which substance does
cause the specified color?
A. sodium sulfate
B. copper sulfate
C. mercury sulfate
D. sulphuric acid
E. zinc sulfate
ANSWER: D
6. Ammonia and hydrogen sulfide were detection in forensic chemical analysis. This is evidence
of:
A. Rotting of biological material
B. Improper conservation of biological material
C. Hydrogen sulfide poisoning
D. Ammonia poisoning
E. Chemical interaction between ammonia and hydrogen sulfide
ANSWER: A
7. What does toxicodynamics study?
A. distribution of poison
B. excretion speed of poisons from the body
C. metabolism of toxic substances in the body
D. mechanisms of poisons action in the body
E. accumulation of poisons
ANSWER: D
8. One of the tasks of toxicological chemistry is:
A. Introduction in practice of chemical-toxicological analysis of new sensitive and specific reactions
and identification methods (chromatography, spectrophotometry, etc.) of toxic substances which
are isolated from the corresponding objects
B. Determination of the median lethal dose
C. Study of the description of what rate a chemical will enter the body
D. Study of pathomorphological signs of intoxication at different routes of poison in the body
E. Study of the influence of toxic substances on the organism, its ability to affect organs, tissues and
change their function
ANSWER: A
9. Chose task which is not task of Toxicology:
A. Developing and introduction of new sensitive methods of toxic substances quantitative
determination in practice of chemical-toxicological analysis
B. Defining zone of acute action
C. Study pathomorphological signs of intoxication at different routes of poison in the body
D. detection and characterization of the chemicals toxic properties that can be cause of pathological
changes in the human or animal
E. Study of the influence of toxic substances on the organism, its ability to affect organs, tissues and
change their function
ANSWER: A
10. Subdivision of CТА is:
A. Prophylactic
B. Analysis of metabolites
C. Sanitary and chemical analysis
D. Toxicodynamics
E. Toxicokinetics
ANSWER: C
11. Division of Toxicological Chemistry is:
A. Analytical Chemistry
B. Prophylactic
C. Toxicodynamics
D. toxicokinetics
E. Chemical-toxicological analysis
ANSWER: E
12. Division of Toxicology is not:
A. Toxicodynamics
B. Prophylactic
C. Forensic Chemistry
D. toxicokinetics
E. Clinical
ANSWER: C
13. Research isolation, identification and quantitative methods of poisons which caused the death
in biological material and real evidence:
A. Prophylactic
B. Forensic Chemistry
C. Toxicodynamics
D. toxicokinetics
E. Clinical
ANSWER: B
14. Subdivision of CТА is:
A. Analysis of metabolites
B. Analysis of residual pesticides
C. Prophylactic
D. Toxicodynamics
E. Toxicokinetics
ANSWER: B
15. Which is subdivision of CТА explored investigation methods of toxic substances in water, soil,
food for the purpose of prevent diseases and deaths?
A. Toxicodynamics
B. Chemical-toxicological analysis
C. Toxicokinetics
D. Analysis of residual pesticides
E. Laboratory analysis of intoxication
ANSWER: D
16. .... is explored the influence of toxic substances on the organism, its ability to affect organs,
tissues and change their function:
A. Prophylactic
B. Sanitary and chemical analysis
C. Analysis of residual pesticides
D. Toxicodynamics
E. Laboratory analysis of intoxication
ANSWER: D
17. ……..is the description of what rate a chemical will enter the body and what happens to it
once it is in the body (its absorption, distribution, biotransformation and excretion).
A. Analysis of residual pesticides
B. Sanitary and chemical analysis
C. toxicokinetics
D. Toxicodynamics
E. Laboratory analysis of intoxication
ANSWER: C
18. The minimum dose which changes vital functions that go beyond the compensatory
physiological responses and is called:
A. Limac; zone of acute action
B. DL50 (DL100) – median (absolute) lethal dose
C. CL50 (CL100) – median (absolute) lethal dose
D. DL50/Limac; zone of acute action
E. Limac - acute action threshold of substance
ANSWER: E
19. One of preliminary test is determining of smell. Which substance gives specific smell of bitter
almonds to the research objects?
A. Morphine
B. Nitric Acid
C. Copper sulfate
D. hydrocyanic acid
E. Cocaine
ANSWER: D
20. Which substance gives specific smell of bitter almonds to the research objects?
A. Morphine
B. Nitric Acid
C. Copper sulfate
D. benzoic aldehyde
E. Cocaine
ANSWER: D
21. Which substance gives specific smell to the research objects?
A. Sulphuric acid
B. Phenol
C. Copper sulfate
D. Codeine
E. Cocaine
ANSWER: B
22. Determination of object color (mostly stomach content) has a value for the previous deduction
that the presence of poison. You have stomach content which has yellow colour. Which
poison can be cause of death?
A. Nitric acid
B. Eosin
C. Ammonia
D. Sulfuric acid
E. Arsenic Compounds
ANSWER: A
23. Determination of object color (mostly stomach content) has a value for the previous deduction
that the presence of poison. You have stomach content which has gray-purple colour. Which
poison can be cause of death?
A. Chromium salt
B. Eosin
C. Ammonia
D. Sulfuric acid
E. Arsenic compounds
ANSWER: A
24. Determination of object color (mostly stomach content) has a value for the previous deduction
that the presence of poison. You have stomach content which has orange colour. Which
poison can be cause of death?
A. Dichromates
B. Mercury bichloride
C. Copper salt
D. Sulfuric acid
E. Chromium salt
ANSWER: A
25. Expert toxicologist uses for the detection oxidizers this substance:
A. Benzydyn
B. Potassium dichromate
C. Potassium permanganate
D. diphenylamine
E. Identified only by smell
ANSWER: D
26. Denitration of mineralisate is doing after mineralization of biological material. Which
substance is used to check of denitration:
A. diphenylamine
B. diphenylcarbazone
C. dithizon
D. thioureas
E. lead diethyldithiocarbamate
ANSWER: A
27. Poisoning was by Silver. Which method don’t use for Silver isolation from biological objects:
A. mineralization by a mixture of sulfuric, nitric and perchloric acids
B. dry ashing method
C. mineralization by mixture of sulfuric and nitric acid
D. interfusion method
E. Destruction
ANSWER: E
28. Different reducers are used for denitration of mineralisate. What the reagent is used for
denitration of mineralisate often?
A. urea
B. thioureas
C. sodium sulfite
D. formaldehyde solution
E. sodium thiosulfate
ANSWER: D
29. Some person was poisoned by "metal" poisons. What "metal" poison is lost in the process of
general mineralization methods?
A. Thallium
B. arsenic
C. Mercury
D. antimony
E. manganese
ANSWER: C
30. Mineralization is divided into two groups of methods - methods of dry and wet
mineralization. To the method of dry mineralization belongs to:
A. mineralization by a mixture of nitric, sulfuric and perchloric acid
B. mineralization by a mixture of nitric and sulfuric acids
C. mineralization by nitric acid
D. dry ashing method
E. mineralization by a mixture of sulfuric acid and perhydrol
ANSWER: D
31. Mineralization is divided into two groups of methods - methods of dry and wet
mineralization. Which method doesn’t belong to wet mineralization:
A. interfusion method
B. mineralization by a mixture of nitric and sulfuric acids
C. mineralization by nitric acid
D. mineralization by a mixture of nitric, sulfuric and perchloric acid
E. mineralization by a mixture of sulfuric acid and perhydrol
ANSWER: A
32. One disadvantage of dry ashing is:
A. Poisons are volatility at high temperature
B. Explosivity
C. Partial oxidation of biological material
D. Slowly oxidation of fats
E. Rapid flow mineralization
ANSWER: A
33. Expert toxicologist does analysis of "mineralizate" on "metallic" poisons. Precipitate is
dissolved in ammonium acetate and yellow precipitate forms at addition potassium
dichromate to it. Which ions are in mineralizate?
A. mercury
B. lead
C. barium
D. silver
E. calcium
ANSWER: B
34. The reaction of the "golden rain" is a reaction of formation:
A. [HgI4]2B. PbI2
C. AlI3
D. HgI2
E. AgI
ANSWER: B
35. Which reagent is used for separation PbSO4 from BaSO4?
A. CH3COONH4
B. NH4Cl
C. Na2CO3
D. (NH4)2CO3
E. KHCO3
ANSWER: A
36. The group of "metal" poisons includes metal. Which non-metal also belongs to this group of
poisons?
A. Arsenic
B. Bismuth
C. Barium
D. Cadmium
E. Sulfur
ANSWER: A
37. White precipitate forms in reaction of sodium sulfide with heavy metal (at pH = 5). Which ion
may be in mineralizate?
A. Lead
B. Copper
C. Zinc
D. Cadmium
E. Bismuth
ANSWER: C
38. It was poisoning by heavy metal. Redox reaction is used for detection of … poison.
A. Bismuth
B. manganese
C. lead
D. copper
E. Zinc
ANSWER: B
39. Forensic toxicologist analyzes the presence of antimony ions in mineralizate. What is a
preliminary reaction?
A. with dithizon
B. zinc sulfate and ammonium tetraiodomercurate
C. Malachite green or diamond green
D. diphenylcarbazone
E. Sodium rodizonate
ANSWER: C
40. Potassium periodate is used for determination of … ions:
A. Bismuth
B. Chromium
C. manganese
D. copper
E. Zinc
ANSWER: C
41. Which reagent is used for preliminary identification of copper ions in mineralizate?
A. sodium diethyldithiocarbamate
B. Lead diethyldithiocarbamate
C. dithizon
D. diphenylcarbazide
E. diphenylamine
ANSWER: B
42. Which reagent is used as preliminary reaction for silver ions in mineralizate?
A. Sulfuric acid
B. dithizon
C. potassium periodate
D. thiourea
E. copper acetate
ANSWER: B
43. There was heavy metal poisoning. Which poison does react with Malachite green and
dithizon?
A. antimony
B. arsenic
C. Silver
D. Thallium
E. Lead
ANSWER: D
44. In the accompanying documentation was write that the corpse has Mees’ lines on nails. What
kind of metal poison is necessary to analyze?
A. Arcenic
B. Antimony
C. Silver
D. Lead
E. Mercury
ANSWER: A
45. Dithizon is used for detection of this metal poison in mineralizate as sustaining reaction.
A. Barium
B. Cadmium
C. Arsen
D. Thallium
E. Silver
ANSWER: D
46. Toxic substances are classified in chemical toxicological analysis depending on their isolation
methods from biological material. To which group belong poisons – pesticides?
A. Substances isolated by special methods
B. Substances isolated by steam distillation
C. Substances analyzed without isolation
D. Substances isolated by organic solvents
E. Substances isolated by water extraction
ANSWER: D
47. All poisons are divided into different groups. How divided poisons by chemical structure?
A. Inorganic, organic, hetero-organic
B. Natural and synthetic
C. Industry, household, pesticides, drugs, biological poisons, chemical warfare agents
D. Extremely toxic, highly toxic, moderately toxic and toxic
E. Neuroparalytic, lachrymatory and irritable, general toxic, blistering, suffocating, psycho toxic
ANSWER: A
48. All poisons are divided into different groups. How divided poisons by origin?
A. Inorganic, organic, hetero-organic
B. Natural and synthetic
C. Industry, household, pesticides, drugs, biological poisons, chemical warfare agents
D. Extremely toxic, highly toxic, moderately toxic and toxic
E. Neuroparalytic, lachrymatory and irritable, general toxic, blistering, suffocating, psycho toxic
ANSWER: B
49. All poisons are divided into different groups. How divided poisons by the practical
application?
A. Inorganic, organic, hetero-organic
B. Natural and synthetic
C. Industry, household, pesticides, drugs, biological poisons, chemical warfare agents
D. Extremely toxic, highly toxic, moderately toxic and toxic
E. Neuroparalytic, lachrymatory and irritable, general toxic, blistering, suffocating, psycho toxic
ANSWER: C
50. All poisons are divided into different groups. How divided poisons by toxicity degree?
A. Inorganic, organic, hetero-organic
B. Natural and synthetic
C. Industry, household, pesticides, drugs, biological poisons, chemical warfare agents
D. Extremely toxic, highly toxic, moderately toxic and toxic
E. Neuroparalytic, lachrymatory and irritable, general toxic, blistering, suffocating, psycho toxic
ANSWER: D
51. All poisons are divided into different groups. How divided poisons by type of the toxic effect?
A. Inorganic, organic, hetero-organic
B. Natural and synthetic
C. Industry, household, pesticides, drugs, biological poisons, chemical warfare agents
D. Extremely toxic, highly toxic, moderately toxic and toxic
E. Neuroparalytic, lachrymatory and irritable, general toxic, blistering, suffocating, psycho toxic
ANSWER: E
52. Which compound is easily absorbed in the stomach?
A. Cocaine
B. Salt of silver
C. Barium salts
D. Salicylates
E. Atropine
ANSWER: D
53. Choose the preliminary reaction for detection of Bi ions in mineralizate?
A. quinoline
B. potassium iodide
C. potassium iodide and 8-oxyquinoline
D. sodium diethyldithiocarbamate
E. brucine and potassium bromide
ANSWER: C
54. Which methods of body detoxification do not belong to the artificial?
A. Hemosorbtion
B. Hemodialysis
C. Blood transfusion
D. Antidote therapy
E. Vomiting
ANSWER: E
55. Choose method of artificial detoxification:
A. Hemodialysis
B. Vomiting
C. Forced diuresis
D. Gastric lavage
E. Hyperventilation of the lungs
ANSWER: A
56. Which substance metabolizes by desulphonation?
A. methanol
B. nitrobenzene
C. thiobarbital
D. codeine
E. phenaminum
ANSWER: C
57. Which substance metabolizes by oxidation on S-atoms?
A. toluene
B. derivatives of phenothiazine
C. benzene
D. aniline
E. phenaminum
ANSWER: B
58. Choose analytical signal of reaction which use in chemical-toxicological analysis: ССl4 +
RNH2 + 4КОН → RN=C + 4КС1 + 3Н2О
A. blood-red color
B. blue precipitate
C. off-flavour
D. pink or red-violet color
E. violet color
ANSWER: C
59. Codeine in our organism is metabolized by О – dealkylation. Choose metabolite of this
compound?
A. nitrosobenzene
B. sulfoxide
C. benzoic acid
D. 2,5-Dihydroxybenzoic acid
E. morphine
ANSWER: E
60. Preliminary reaction for detection hydrocyanic acid in distillate is reaction with:
A. polymethine dye formation
B. with picric acid
C. Prussian blue formation
D. with resorcinol
E. benzidine blue formation
ANSWER: C
61. Which analytical signal of reaction chloroform with an alcoholic solution of alkali, after
addition silver nitrate?
A. blood-red color
B. white precipitate
C. orange color
D. violet color
E. blue-violet color
ANSWER: B
62. Choose process of I phase of biotransformation?
A. Conjugation by glycine
B. Conjugation by Glutathione
C. Acetylation
D. Methylation
E. Hydrolysis
ANSWER: E
63. Preliminary reaction for detection phenol in distillate is reaction with:
A. indophenol reaction
B. with iron (III) chloride
C. Fujiwara
D. with resorcinol
E. with bromine water
ANSWER: E
64. Choose analytical signal of reaction which use in chemical-toxicological analysis: НССН +
2CuNO3 + 2NH4OH → CuCCCu + 2NH4NO3 + 2H2O
A. blood-red color
B. blue precipitate
C. orange color
D. pink or red-violet color
E. violet color
ANSWER: D
65. Which analytical signal of reaction formaldehyde with Fehling’s solution?
A. blood-red color
B. blue precipitate
C. red precipitate
D. violet color
E. blue-violet color
ANSWER: C
66. Which compound is used for acidification of biological material at steam distillation?
A. hydrochloric acid
B. tartaric acid
C. acetic acid
D. sodium hydroxide
E. water
ANSWER: B
67. It was observed the olive green urine. Which compound may be cause of poisoning distillate?
A. Hydrocyanic acid
B. Chloral hydrate
C. Formaldehyde
D. Phenol
E. Carbon tetrachloride
ANSWER: D
68. Preliminary reaction for detection formaldehyde in distillate is reaction with:
A. silver ions reduction
B. with Fehling’s solution
C. with fuchsine sulfurous acid
D. with resorcinol
E. with methyl violet
ANSWER: C
69. Which analytical signal of reaction phenol with Millon's reagent?
A. green color
B. light-brown color
C. white precipitate
D. violet color
E. red color
ANSWER: E
70. Preliminary reaction for detection ethylene glycol in distillate is reaction with:
A. formation of an ester
B. iodoform formation
C. ethyl benzoate formation
D. with sodium nitroprusside
E. potassium periodate
ANSWER: E
71. Choose sustaining reaction for detection of acetone in distillate is reaction with:
A. formation of an ester
B. iodoform formation
C. ethyl benzoate formation
D. sodium nitroprusside
E. potassium periodate
ANSWER: D
72. Preliminary reaction for detection acetic acid in distillate is reaction with:
A. formation of an ester
B. iodoform formation
C. ethyl benzoate formation
D. with sodium nitroprusside
E. iron (III) chloride
ANSWER: E
73. Which "volatile" poison does cause incurable blindness?
A. tetrachlormethane
B. acetic acid
C. acetone
D. ethanol
E. methanol
ANSWER: E
74. Which “volatile” poison is used as antifreeze?
A. tetrachlormethane
B. acetic acid
C. isoamyl alcohol
D. formaldehyde
E. ethylene glicol
ANSWER: E
75. Choose analytical signal of reaction which use in chemical-toxicological analysis: 8СН3СОО+ 3Fe3+ + 2Н2О  [Fe3(ОН)2(СН3СОО)6]+ + 2СН3СООН
A. smell
B. blue colour
C. orange color
D. red color
E. violet color
ANSWER: D
76. Choose sustaining reaction for detection of methanol in distillate is reaction with:
A. formation of formaldehyde
B. methyl salicylate formation
C. ethyl benzoate formation
D. sodium nitroprusside
E. potassium periodate
ANSWER: B
77. Choose analytical signal of reaction which use in chemical-toxicological analysis: Н2С2О4 +
Са2+  СаС2О4 + 2Н+
A. smell
B. blue colour
C. orange color
D. red color
E. white precipitate
ANSWER: E
78. Acetaldehyde is metabolite of … poison.
A. acetic acid
B. ethanol
C. acetone
D. formaldehyde
E. methanol
ANSWER: B
79. Which reaction isn’t used for detection of acetone?
A. with furfurol
B. formation of indigo
C. iodoform formation
D. with iron (III) chloride
E. with o-nitrobenzaldehyde
ANSWER: D
80. Preliminary reaction for detection ethylene glycol in distillate is reaction with:
A. formation of an ester
B. iodoform formation
C. ethyl benzoate formation
D. sodium nitroprusside
E. oxidation to formaldehyde
ANSWER: E
81. Choose especially of acetone isolation.
A. usage of benzene as a selective transporter
B. distillate must be cooled by cold water or ice
C. salting out by sodium chloride, calcium chloride, potassium carbonate
D. collected in alcoholic solution of iodine
E. without especially
ANSWER: C
82. Preliminary reaction for detection isoamyl alcohol in distillate is reaction with:
A. formation of an ester
B. iodoform formation
C. ethyl benzoate formation
D. with sodium nitroprusside
E. with potassium permanganate
ANSWER: A
83. Which reaction isn’t used for detection of acetic acid?
A. formation of indigo
B. with methanol
C. with ethanol
D. with iron (III) chloride
E. with lanthanum nitrate and iodine
ANSWER: B
84. Choose analytical signal of reaction which use in chemical-toxicological analysis:
2CH3COONa + 2С2Н5ОН + H2SO4  2СН3СООС2Н5 + Na2SO4 + 2Н2О
A. smell
B. blue colour
C. orange color
D. red color
E. white precipitate
ANSWER: A
85. Choose analytical signal of reaction which use in chemical-toxicological analysis: 5СН3ОН +
2КМnО4 + 3H2SO4  5НСНО + 2MnSO4 + K2SO4 + 8Н2О.
A. smell
B. blue colour
C. orange color
D. red color
E. colourless solution
ANSWER: E
86. Which reaction isn’t used for detection of acetone?
A. formation of indigo
B. formation of isovaleric acid aldehyde
C. with furfurol
D. with o-nitrobenzaldehyde
E. with sodium nitroprusside
ANSWER: B
87. Preliminary reaction for detection methanol in distillate is reaction with:
A. formation of an ester
B. iodoform formation
C. ethyl benzoate formation
D. with sodium nitroprusside
E. with potassium permanganate
ANSWER: E
88. Preliminary reaction for detection ethanol in distillate is reaction with:
A. formation of an ester
B. iodoform formation
C. ethyl benzoate formation
D. with sodium nitroprusside
E. oxidation to formaldehyde
ANSWER: B
89. Which method of titrimetry is used for quantitative analysis of formaldehyde?
A. bromatometry
B. argentometry
C. iodometry
D. protolytometry
E. permanganatometry
ANSWER: C
90. Choose especially of ethanol isolation.
A. usage of benzene as a selective transporter
B. distillate must be cooled by cold water or ice
C. salting out by sodium chloride, calcium chloride, potassium carbonate
D. collected in alcoholic solution of iodine
E. without especially
ANSWER: E
91. You may use titrimetry as method of poisons quantitative analysis. Protolytometry is used for
quantitative analysis of which poison.
A. hydrocianic acid, alkyl halides
B. acetic acid
C. phenol
D. formaldehyde, acetone
E. methanol
ANSWER: B
92. Choose sustaining reaction for detection of acetone in distillate is reaction with:
A. formation of formaldehyde
B. salicylaldehyde
C. furfurol
D. copper sulfate
E. potassium periodate
ANSWER: C
93. Choose analytical signal of reaction which use in chemical-toxicological analysis: HO-СН2СН2-ОН + KIO4 + Н+  2НСНО + HIO3 + Н2О + К+ at addition 3-5 drops of sulfurous acid
solution and then 4 drops of fuchsine sulfurous solution.
A. red-purple
B. blue colour
C. orange color
D. dark-red color
E. colourless solution
ANSWER: B
94. You may use gravimetry as method of poisons quantitative analysis. Which "volatile" poison
may be defined by this method?
A. tetrachlormethane
B. acetic acid
C. isoamyl alcohol
D. formaldehyde, acetone
E. methanol
ANSWER: A
95. Which poison is used as vinegar?
A. lead tetraethyl
B. acetic acid
C. acetone
D. phenol
E. ethylen glycol
ANSWER: B
96. Choose analytical signal of reaction which use in chemical-toxicological analysis: І3С-СО-СН3
+ ОН-  СНІ3 + СН3СООA. yellow precipitate
B. blue colour
C. orange color
D. dark-red color
E. colourless solution
ANSWER: A
97. Preliminary reaction for detection acetone in distillate is reaction with:
A. formation of an ester
B. iodoform formation
C. ethyl benzoate formation
D. with sodium nitroprusside
E. oxidation to formaldehyde
ANSWER: B
98. Choose sustaining reaction for detection of acetic acid in distillate is reaction with:
A. formation of formaldehyde
B. salicylaldehyde
C. furfurol
D. lanthanum nitrate and iodine
E. potassium periodate
ANSWER: D
99. Which “volatile” poison doesn’t dissolve in water?
A. tetrachlormethane
B. acetic acid
C. isoamyl alcohol
D. formaldehyde, acetone
E. methanol
ANSWER: C
100. Preliminary reaction for detection methanol in distillate is reaction with:
A. formation of an ester
B. iodoform formation
C. ethyl benzoate formation
D. with sodium nitroprusside
E. oxidation to formaldehyde
ANSWER: E