Supplementary Table 1. Protocols of intra-coronary provocative tests with Achetilcoline
Author
IC
year
Route
Sueda
Yes
Dosage
Administration
Mandatory
Modality
pacing
Yes
Sides effects
20, 50 and
Incremental doses over
2008
100 μg (LCA)
20 sec with at least a 3-
shock (0.3%),
(14)
or 20, 50 and
min interval between
cardiac
80 μg (RCA)
each injection
tamponade
in 5 ml NS *
NsVT (1.1%).
(0.1%), PAF
(17.1%)
Ong
Yes
2, 20, 100, and
Incremental doses over
No/Bailout
PAF (0.1%),
2014
200 μg (LCA)
3 min
(15)
or 80 μg
bradycardia
(RCA) * *
(0.6%), catheter-
NsVT (0.1%),
induced spasm
(0.1%)
Wei
0.182, 1.82
Incremental doses over
2012
and 18.2
3 min
(16)
μg/ml in 2 ml
coronary artery
NS * *
dissection)
***
Yes
Yes
20, 50, 100 μg Incremental doses over
in 2 ml NS* *
3 min
No/Bailout
CRT-SAEs:02%
(MI and
No/Bailout
Bradycardia
(0.1%),
NsVT (0.1%)
*=Achetilcoline chloride (Neucholin-A, 30mg/2mL); * * =Achetilcoline chloride (Miochol, 20
mg/2mL); * * * Unpublished data about IC Ach test protocol used in our Institute: a drug
formulation employed for ocular disease is diluted as reported.
Intracoronary nitrates are usually administered at the end of the protocol and a final coronary
angiography after nitrates is performed
Ach=Achetilcoline; CAS=coronary artery spasm; CRT-SAEs=coronary reactivity testing related
serious adverse events; IC=intra-coronary; LCA=left coronary artery; MI=myocardial infarction;,
NS=normal solution; NsVT=nonsustained ventricular tachycardia; PAF=paroxysmal atrial
fibrillation; RCA=right coronary artery.