Faculty of Pharmacy
Biopharmaceutics and Pharmacokinetics Lab (501474)
Course Outline
Spring Term 2012-2013
Clinical Instructor: Arabieh Magableh, MSc. Clinical Pharmacy, IPP.
Office Hours: Daily, 11 -12 p.m.
Course Description: This course clarifies the physico-chemical factors involved in the drug’s
absorption, distribution, and elimination. Along with calculating drug levels in blood and
urine, given as single or multiple IV/oral doses, through resolving case studies.
Lab Outcomes:
By the end of this course, the student should be:
 Familiar with the concepts of pharmacokinetics models & parameters.
 Able to solve problems concerned with various pharmacokinetics parameters and
figuring out the plasma/urine concentrations.
Textbook:
 Shargel L., Wu-Pong S., Yu A. (2012). Applied Biopharmaceutics and
pharmacokinetics.
Contents:
Week
Date
1
2
3
4
17/2 – 21/2
24/2 – 28/2
3/3 – 7/3
10/3 – 14/3
5
17/3 – 21/3
6
24/3 – 28/3
7
8
9
10
11
12
13
31/3 – 4/4
7/4 – 11/4
14/4 – 18/4
21/4 – 25/4
28/4 – 2/5
5/5 – 9/5
12/5 – 16/5
Topic
Induction week - lab course plan
Biopharmaceutics and Pharmacokinetics principles
One compartment model: Treatment of IV bolus data
Evaluation of drug kinetics utilizing urinary excretion
method
One compartment model: Treatment of IV infusion
data
One compartment model: Evaluation of absorption
Kinetics
Midterm Exam Week
Two compartments model: Treatment of IV bolus data
Kinetics of multiple dosing: IV bolus
Kinetics of multiple dosing: Oral administration
Designing dosing regimens
Revision Session
Final Exam
1
General Instructions:


Each time you attend, you should bring Cartesian papers and a calculator with log, In
and exponential functions.
A quiz will be given at the beginning of each lecture.
Attendance Policy:
 Be punctual.
 Attendance is mandatory, but you are allowed not to miss more than 15% of the
lectures (two lectures), without an acceptable and proper reason.
 If you miss more than two lectures, you will be given zero in the course, or to be
considered as a withdrawal.
 Only students’ medical reports are looked in.
In the lecture hall:
 Mobile phones should be shut off or put on silent in the lecture hall and they are not
allowed in the exams.
 Gum, sandwiches, and beverages are banned.
 The medical report should be presented within 72 hours after the end of cause.
Evaluation: (out of 100%)
 Attendance: 10 marks.
 Quizzes: 10 marks.
 Assignments: 10 marks.
 Midterm Exam: 30 marks.
 Final Exam: 40 marks.
* Exams are comprehensive, and there will be no makeup exams at all unless allowed by
the deanship).
Holidays:
 Isra and Mi'raj day: Friday, October 26th – Tuesday, October 30th.
 Hijri New Year: Thursday, November 15th, 2012.
 Christmas Day: Tuesday, December 25th, 2012.
 New Year: Tuesday, January 1st, 2013.
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