European Journal of
Clinical Pharmacology
Volume 64 Number 1 January 2008
DEBATE ARTICLE
The conscientious judgement of a DSMB - statistical
stopping rules re-examined
K, Hedenmalm ■ H. Melander ■' G. Aivan
CONICAL TRIAL
Endocannabinoids in platelets of chronic migraine
patients and medication-overuse headache patients:
relation with serotonin levels
C, Rossi ■ LA. Pini ■ M.L. Cupini ■ P. Calabresi • P. Sarchielli
69
SHORT COMMUNICATIONS ■
1
Increased use of second generation antipsychotic drugs
in primary care: potential relevance for hospitalizations
in schizophrenia patients
M.C Caceres ■ E.M. Penas-LLedd ■ A. de la Rubia ■ A.
PHARMACOGENETICS
CYP2C9 genotypes and the quality of anticoagulation
control with warfarin therapy among Brazilian patients
LLerena
73
M.V. Lima ■ G.S. Ribeiro ■ E.T. Mesquita ■ P.R. Victer ■ R.
Effect of kolanut on the pharmacokinetics of the
antimalarial drug halofantrine
Vianna-Jorge 9
Y.T. Kolade ■ C.P. Babalola ■ A.A. Olaniyi ■ G.K.E. Scriba
PHARMACOKINETJCS AND DISPOSITION
Comparison of carbamazeptne and oxcarbazepine effects
on aminothiol levels
Effects of gender and moderate smoking on the
pharmacokinetics and effects of the CYP1A2 substrate
tizanidine
J.T. Backman ■ M.T. Schroder ■ P.J. Neuvonen
17
Effect of voriconazole and fluconazole on the
pharmacokinetics of intravenous fentanyl
S. Badiou ■ H. Breton ■ H. Peyriere ■ V. Charasson ■ A. Crespel ■
P. Gelisse ■ J.-P. Cristol ■ D. Hillaire-Buys 83
Greater impact of oral fluconazole on drug interaction
with intravenous calcineurin inhibitors as compared with
intravenous fluconazole
A. Mihara - T. Mori ■ Y. Aisa ■ R. Yamazaki ■ 0. Iketani ■ Y.
Tanigawara ■ Y. Ikeda ■ S. Okamoto
T.I. Saari ■ K. Laine ■ M. Neuvonen ■ P.J. Neuvonen ■
K.T. Olkkola
77
89
25
LETTER TO THE EDITORS
The effects of CYP3A4 inhibition on erlotinib
pharmacokinetics: computer-based simulation
(SitriCYP™) predicts in vivo metabolic inhibition
Tofisopam inhibits the pharmacokinetics of CYP3A4
substrate midazolam
A. Rakhit ■ M.P. Pantze ■ S. Fettner ■ H.M. Jones ■ J.-
M. Toth ■ 5. Drabant ■ B. Varga ■ G. Vegso ■ A. Cseh ■ I.
E, Charoin ■ M. Riek ■ B.L. Lum ■ M. Hamilton
Szentpeteri ■ I. Klebovich
31
93
Mutual pharmacokinetic interactions between
steady-state bosentan and sildenafil
G. Burgess ■ H. Hoogkamer ■ L. Collings ■ J. Dingemanse
43
PHARMACOEPIDEMIOLOGY AND PRESCRIPTION
Further articles can be found at www.springerlink.com Indexed
Factors associated with changes in antidepressant
use in a community-dwelfing elderly cohort: the
Three-City Study
in/abstracted by Current Contents and Index Medicus.
A. Soudry ■ C. Dufouil ■ K. Ritchie ■ J.-F. Dartigues ■ C.
Tzourio ■ A. Alperovitch
51
Development of NSAIDs prescription indicators based on
health outcomes
R. Fernandez Urrusuno ■ M.P. Gonzalez ■ M.A. Torrecilla Rojas 61
Instructions for Authors for EurJClin Pharmacol are available at
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