Course Form (revised 7-2008)
I. Summary of Proposed Changes
Dept / Program
BMED
Course Title
Advanced Pharmaceutics
Short Title (max. 26 characters incl. spaces)
Summarize the change(s) proposed
Course #
632
Change title of course to “Advanced
Pharmacokinetics”, change the course description,
change the credits to 4 (from variable 1-3 cr), offered
every fall semester (from intermittently).
II. Endorsement/Approvals
Complete the form and obtain signatures before submitting to Faculty Senate Office
Please type / print name Signature
Requestor:
Erica Woodahl
Phone/ email :
x4129
erica.woodahl@umontana.edu
Program Chair/Director:
Rich Bridges
Other affected programs:
Dean:
Date
Dave Forbes
III: To Add a New Course Syllabus and assessment information is required (paste syllabus into
section V or attach). Course should have internal coherence and clear focus.
Exact entry to appear in the next catalog (Specify course abbreviation, level, number, title, credits,
repeatability (if applicable), frequency of offering, prerequisites, and a brief description.) 
Justification: How does the course fit with the existing curriculum? Why is it needed?
Are there curricular adjustments to accommodate teaching this course?
Complete for UG courses. (UG courses should be assigned a 400 number).
Describe graduate increment (Reference guidelines: http://www.umt.edu/facultysenate/Grad/UG.htm)
Fees may be requested only for courses meeting specific conditions determined by the
Board of Regents. Please indicate whether this course will be considered for a fee.
If YES, what is the proposed amount of the fee?
Justification:
IV. To Delete or Change an Existing Course – check X all that apply
Deletion
Title
Course Number Change
From:
Level U, UG, G
To:
Description Change X
Change in Credits X
Recent developments and
emerging concepts in
theoretical and experimental
pharmacokinetics,
pharmacogenomics, and drug
disposition. Critical analysis
of the current literature.
From:
1-3 cr
To:
4 cr
Repeatability
Cross Listing
(primary program
initiates form)
YES
From:
To:
NO
Prerequisites
None
1. Current course information at it appears in catalog
(http://www.umt.edu/catalog) 
G 632 Advanced Pharmaceutics 1-3 cr. (R-6) Offered
intermittently. Advanced studies of dosage formulations,
biopharmaceutics, and pharmacokinetics.
3. If cross-listed course: secondary program & course
number
4. Graduate increment if level of course is changed to
UG. Reference guidelines at:
http://www.umt.edu/facultysenate/Grad/UG.htm
(syllabus required in section V)
5. Other programs affected by the change
6. Justification for proposed change
Is there a fee associated with the course?
2. Full and exact entry (as proposed) 
No
G 632 Advanced Pharmacokinetics 4 cr. Offered
Fall. Recent developments and emerging
concepts in theoretical and experimental
pharmacokinetics, pharmacogenomics, and drug
disposition. Critical analysis of the current
literature.
Have you reviewed the graduate increment
guidelines? Please check (X) space provided.
BMED632 has not been taught for many years. I
am a new faculty and am restarting this class. I
am substantially updating the class and
integrating a lecture component with a
discussion component, which will focus on
experimental methods and current literature
analyses. The current title (Advanced
Pharmaceutics) is not reflective of what my
revamped course will cover. Pharmaceutics is a
broad topic encompassing dosage formulations,
physiochemical properties of a drug,
biopharmaceutics, and drug delivery (as well as
pharmacokinetics). These other topics besides
pharmacokinetics will not be covered in this
course and therefore the current title is
misleading. Pharmaceutics is also an antiquated
term and does not reflect the innovation and
current research focus that Pharmacokinetics
encompasses. The change to a title of
“Advanced Pharmacokinetics” is therefore
necessary for this redesigned and updated
course. Advanced Pharmacokinetics will cover
all aspects of drug disposition, which includes
absorption, distribution, metabolism, and
elimination of a drug, as well as incorporating
new and innovative areas of research in drug
transporters and pharmacogenomics.
I am also requesting a change of credit number.
Previously the class was offered intermittently
for 1-3 credits, based on graduate student interest
and enrollment. My updated class will be
structured with consistent class times every
week: 3 credit hours will be in class lecture
format and the 4th credit will be a separate
discussion section meeting time focusing on
research and current literature.
The class will meet in the fall semester to
coincide with the class BMED 432, which will
comprise the lecture component. The change in
title for BMED 632 will also match a change in
the course name for BMED 432 that I will be
proposing in the fall 2009 - from
“Biopharmaceutics and Pharmacokinetics” to
“Clinical Pharmacokinetics”.
V. Syllabus/Assessment Information
Required for new courses and course change from U to UG. Paste syllabus in field below or attach and send
digital copy with form.
VI Department Summary (Required if several forms are submitted) In a separate document list course
number, title, and proposed change for all proposals.
VII Copies and Electronic Submission. After approval, submit original, one copy, summary of
proposals and electronic file to the Faculty Senate Office, UH 221, camie.foos@mso.umt.edu.
Advanced Pharmacokinetics
BMED 695 Section 01
Fall 2009
Erica Woodahl, Ph.D. – Course Coordinator
Office: SB 477B
Phone: x4129
email: erica.woodahl@umontana.edu
Lecturers:
Erica Woodahl, Ph.D.
Howard Beall, Ph.D.
John Gerdes, Ph.D.
Mark Pershouse, Ph.D.
phone: x5112
phone: x4084
phone: x4084
email: howard.beall@umontana.edu
email: john.gerdes@umontana.edu
email: mark.pershouse@umontana.edu
Course Time and Location:
Tuesdays and Thursdays 1:40-3:00p, SB 169 – in conjunction with BMED 432
Wednesdays 2-4p
Office Hours: Arranged by each faculty member
Course Description:
Pharmacokinetics describes the time course of a drug in the body and is the critical piece in determining drug design
and dosing regimens. This course provides the basic principles of pharmacokinetics including the processes of
ADME (Absorption, Distribution, Metabolism, and Elimination) and their application to the clinical setting, including
single-dose intravenous and oral kinetics, multiple dosing, nonlinear pharmacokinetics, metabolite kinetics,
pharmacogenetics, role of disease in drug clearance and dose requirements, and kinetics of drug-drug interactions.
In addition, this course will provide a more in advanced discussion of the application of pharmacokinetics in research
and drug development.
Required Textbooks:
Tozer and Rowland. Introduction to Pharmacokinetics and Pharmacodynamics.
Shargel, Wu-Pong, and Yu, Applied Biopharmaceutics and Pharmacokinetics. (5th edition)
Exams:
Exam #1
Exam #2
Exam #3
Final Written Exam
Final Oral Exam
20%
20%
20%
20%
20%
Lectures 9/1 – 9/22
Lectures 9/29 – 10/15
Lectures 10/20 – 11/17
~60% new; ~40% cumulative
Cumulative
Exams will cover materials from lectures, and assigned readings. Exams will use multiple choice, calculations, and
short answer formats. Calculations of pharmacokinetic parameters and dosage regimens will be required. A
calculator is required. Examinations will be administered in class during the allotted time.
Students are expected to take all exams at the scheduled time. If you are unable to take an exam due to sudden
illness or family emergency, notify Erica Woodahl as soon as possible to schedule a make-up exam.
If you have a question regarding the grading of your exam, an appointment must be scheduled within 10 days
following the return of your exam. After that time, adjustments to your grade will not be made.
Grading Scale: The plus/minus grading system will be used: A- = 90%, B- = 80%, C- = 70%, D- = 65%
Expectations for Academic Honesty at UM: All students must practice academic honesty. Academic misconduct
is subject to an academic penalty by the course instructor and/or a disciplinary sanction by the University. All
students need to be familiar with the Student Conduct Code: http://www.umt.edu/SA/VPSA/index.cfm/page/1321
Expectations for Student Behavior: Students are expected to arrive on time for class and workshops. Respectful
and courteous behavior to your classmates, teaching assistants, and instructor will be expected at al times.
PLEASE turn off all cell phones and other electronic devices that may distract you and others prior to
entering class.
LECTURE SCHEDULE
DATE
TOPICS
READINGS
INSTRUCTOR
WEEK 1
T (9/1)
Introduction to Pharmacokinetics and IV Kinetics
Chapters 1 and 2
EW
WEEK 2
Th (9/3)
T (9/8)
Chapter 5
Chapter 5
EW
EW
WEEK 3
Th (9/10)
T (9/15)
Chapter 5
Chapter 5
EW/JG
EW
WEEK 4
Th (9/17)
T (9/22)
Clearance Concepts
Chapter 5
Chapter 5
EW
EW
WEEK 5
Th (9/24)
T (9/29)
EXAM #1
Drug Absorption and Bioavailability
Chapters 4 and 6
EW/JG
WEEK 6
Th (10/1)
T (10/6)
Oral Kinetics
Dosing Regimens I
Chapter 6
Chapters 8, 9, and 10
EW
EW
WEEK 7
Th (10/8)
T (10/13)
Dosing Regimens II
Dosing Regimens III
Chapters 8, 9, and
Chapters
8, 9, and 10
10
EW
EW
Th (10/15)
T (10/20)
Dosing Regimens IV
WEEK 8
Chapters 8, 9, and
Chapters
3 and 7
10
EW
JG
WEEK 9
Th (10/22)
T (10/27)
Chapter 4
EW
WEEK 10
Th (10/29)
T (11/3)
Chapter 4
Chapter 11 and 12
EW
EW
Th (11/5)
T (11/10)
Chapter 11 and 12
EW
WEEK 11
EW
EW
WEEK 12
Th (11/12)
T (11/17)
Chapter 11 and 12
Chapter 11 and 12
Chapter 11 and 12
EW
WEEK 13
Th (11/19)
T (11/24)
EXAM #3
Pharmacokinetic Imaging
WEEK 14
Th (11/26)
T (12/1)
Thanksgiving – NO CLASS
WEEK 15
Th (12/3)
T (12/8)
FINAL
Elimination Half-Life
Volume of Distribution; Plasma and Tissue
2
compartment models
Binding
Renal Clearance and Urinary Kinetics
Clearance Concepts
Pharmacokinetic-Pharmacodynamic
Relationships
EXAM #2
Drug Transporters
Drug Transporters
Pharmacogenomics
Pharmacogenomics
Physiologic Factors on Pharmacokinetics
Physiologic Factors on Pharmacokinetics
Physiologic Factors on Pharmacokinetics
JG
EW
Nonlinear Pharmacokinetics
Metabolite Kinetics
Drug Interactions
Th (12/10)
Drug Interactions
Th (12/17)
FINAL EXAM
1:10-3:10p
SB 169
Chapter 11 and 12
EW
EW
Chapter 11 and 12
EW
DISCUSSION SCHEDULE
DATE
WEEK 1
Wed (9/2)
TOPICS
INSTRUCTOR
Introduction: the ADME Concept and Mathematical Principles
EW
Readings: Shargel, Ch. 1 and 2
WEEK 2
Wed (9/9)
Physiology Processes in Pharmacokinetics
EW/MP
Readings: Handout from A&P text
WEEK 3
Wed (9/16)
Intravenous Dosing: Disposition based on plasma data
EW
Readings: Shargel, Ch. 3
WEEK 4
Wed (9/23)
Intravenous Dosing: Compartmental models
EW/JG
Readings: Shargel, Ch. 4
WEEK 5
Wed (9/30)
Extravascular Dosing and Bioavailability
EW
Readings: Shargel, Ch. 7, 11 (pp 332-338), 13, and 15 (453-465)
WEEK 6
Wed (10/7)
Clearance Concepts
EW
Readings: Shargel, Ch. 6 and 11 (pp 338-348)
WEEK 7
Wed (10/14)
Clearance Concepts
EW
Readings: Shargel, Ch. 6 and 11 (pp 338-348)
WEEK 8
Wed (10/21)
pH/pKa Relationships in Drug Absorption and Distribution
HB
Readings: Tozer, Appendix B; and Shargel, Ch. 13
WEEK 9
Wed (10/28)
Plasma Protein Binding and Distribution
EW
Readings: Shargel, Ch. 10
WEEK 10
Wed (11/4)
Drug-Metabolizing Enzymes
EW/JG
Readings: Shargel, Ch. 11 (pp 303-332)
WEEK 11
Wed (11/11)
Drug Transporters
EW
Readings: Shargel, Ch. 11 and 13
WEEK 12
Wed (11/18)
Pharmacogenomics
Readings: Shargel, Ch. 12
WEEK 13
Wed (11/25)
Thanksgiving – No Class
EW
WEEK 14
Wed (12/2)
Enzyme Kinetics and Nonlinear Kinetics
EW
Readings: Shargel, Ch. 9
WEEK 15
Wed (12/9)
Drug Interactions
Readings: Shargel, Ch. 11 (pp 308-312) and 20 (pp 642-650)
FINAL
TBA
ORAL EXAM
EW