European Journal
of Clinical Pharmacology
Volume 64 • Number 10 • October 2008
REVIEW ARTICLES
Proton pump inhibitors: an update of their clinical use
and pharmacokinetics
S. Shi ■ U. Klotz 935
Evidence for a pharmacogenetic adapted dose of oral
anticoagulant in routine medical practice
L. Betquemont 953
CLINICAL TRIAL
Effect of nebicapone on the pharmacokinetics and,
pharmacodynamics of warfarin in healthy subjects
L. Almeida ■ A. Falcao ■ M. Vaz-da-Si!va ■ T. Nunes ■ A.-T. Santos ■ J.F. Rocha ■ C. Neta ■ T. Macedo ■ C. Fontes-Ribeiro ■ P. Soares-daSilva 961
PHARMACOGENETICS
Relationship between CYP2C8 genotypes and diclofenac 5hydroxylation in healthy Spanish volunteers
P. Dorado ■ I. Cavaco ■ M.C. Caceres ■ R. Piedade ■ V. Ribeiro ■
A. LLerena 967
Relationships between specific serum IgE, IgG, IFN-7
level and IFN-y, IFNR1 polymorphisms in patients with
penicillin allergy
N. Gao ■ H.-L Qiao ■ L.-J. Jia ■ X. Tian ■ Y.-W. Zhang 971
Semi-quantitative CYP2D6 gene doses in relation to
metabolic ratios of psychotropics
J.WJ- Hinrichs ■ H.M. Loovers - B. Scholten - J. van der Weide 979
PHARMACOKINETICS AND DISPOSITION
Antibiotic prescribing patterns and hospital admissions with
respiratory and urinary tract infections
R. Fernandez Urrusuno ■ M. Pedregal Gonzalez •
Ma.A. Torrecilla Rojas 1005
Antiepileptic drug utilization in children from
1997-2005— a study from the Netherlands
N.W. van de Vrie-Hoekstra ■ T.W. de Vries ■ P.B. van den Berg ■
O.F. Brouwer ■ L.T.W. de Jong-van den Berg 1013
Discontinuation of ropinirole and pramipexole in patients
with Parkinson's disease: clinical practice versus clinical trials
M.E.L Arbouw ■ K.L.L. Movig ■ H.-J. Guchelaar ■ PJ.E. Poels ■
J.RR van Vugt ■ C Neef ■ ICG. Egberts 1021
SHORT COMMUNICATION
Effect of food on systemic exposure to niflumic acid
following postprandial administration of talniflumate
W. Kang ■ K. Kim ■ E.-Y. Kim ■ K.-i. Kwon ■ J.S. Bang ■ Y.-R. Yoon
1027
LETTERS TO THE EDITORS
Hypercalcemia due to an interaction of all-trans retinoic
acid (ATRA) and itraconazole therapy for acute promyelocytic
leukemia successfully treated with zoledronic acid
R. Cordoba ■ E. Ramirez ■ S.H. Lei ■ A. Lopez de !a Guia ■ MJ.
Sanjurjo ■ AJ. Carcas ■ F. Hernandez-Navarro 1031
No role for the CYP3A5*3 polymorphism in intestinal
and hepatic metabolism of midazolam
D. Tomalik-Scharte ■ 0. Doroshyenko ■ J. Kirchheiner ■ A. Jetter ■ A.
Lazar ■ T. Klaassen ■ D. Frank ■ C. Wyen ■ G. Fatkenheuer ■ U.Fuhr
1033
Chloroquine pharmacokinetics in pregnant and nonpregnant
women with vivax malaria
SJ. Lee • R. McGready ■ C. Fernandez ■ K. Stepniewska ■ M.K. Paw ■
SJ. Viladpai-nguen ■ K.L Thwai ■ L. Villegas ■ P. Singhasivanon ■ B.M.
Greenwood ■ N J. White ■ F. Nosten 987
Absence of time-dependent artesunate pharmacokinetics in
healthy subjects during 5-day oral administration
L.T. DiemThuy ■ L Ngoc Hung ■ P.T. Danh ■ K. Na-Bangchang 993
Further articles can be found at www.springerlink.com Indexed
in/abstracted by Current Contents and Index Medicus.
PHARMACOEPIDEMIOLOGY AND PRESCRIPTION
Women encounter ADRs more often than do men
Y. Zopf ■ C. Rabe ■ A. Neubert ■ K.G. GaBmann ■ W. Rascher ■
E.G. Hahn ■ K. Brune ■ H. Dormann 999
Instructions for Authors for EurJClin Pharmacol are available at
www.springer.com/00228.