Sarcoma & Bone Cancer
July 2014
This bulletin covers sarcomas, soft tissue tumours and bone cancers, and should be of interest to
multidisciplinary teams working in this area.
Sections can include:
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Combined Modality Therapies
Drug Therapy
Pathology, Staging, Polymorphisms & Biomarkers
Prognosis, Survival & Risk Factors
Radiotherapy & Imaging
Supportive Care & Symptom Management
Surgery
Many of the following articles are available online via the NHS Scotland Knowledge Network.
Please use the links where provided and your ATHENS password. A complete list of
available online journals and registration for ATHENS can be found at
www.knowledge.scot.nhs.uk/
If the article you require is not available via the NHS Scotland Knowledge Network and you
would like to request a print copy, please submit your request online at
www.quest.scot.nhs.uk
This bulletin contains a selection of material gathered from a search of the evidence base, and is
not intended to be comprehensive. Professional judgment should be exercised when appraising
the material. The Library takes no responsibility for the wording, content and accuracy of the
information supplied, which has been extracted in good faith from reputable sources. NHSGGC is
not responsible for the content of external internet sites.
Compiled by:
Kirsty Coltart
Subject Librarian
Beatson West of Scotland Cancer Centre
0141 301 7285, kirsty.coltart@ggc.scot.nhs.uk
1
General
Bianchi, G., Charoenlap, C., Cocchi, S., et al. (2014). Clear cell sarcoma of soft tissue: a
retrospective review and analysis of 31 cases treated at Istituto Ortopedico Rizzoli.
European Journal of Surgical Oncology 40,5:505-510.
Blay, J.Y., Sleijfer, S., Schoffski, P., et al. (2014). International expert opinion on patienttailored management of soft tissue sarcomas. European journal of cancer 50,4:679-689..
Egas-Bejar, D. and Huh, W.W. (2014). Rhabdomyosarcoma in adolescent and young adult
patients: current perspectives. Adolescent Health Medicine & Therapeutics 5,115-125.
Haddox, C.L., Han, G., Anijar, L., et al. (2014). Osteosarcoma in pediatric patients and
young adults: a single institution retrospective review of presentation, therapy, and
outcome. Sarcoma 2014,402509.
Henderson, M., Neumeister, M.W. and Bueno, R.A.,Jr. (2014). Hand tumors: II. Benign and
malignant bone tumors of the hand. Plastic & Reconstructive Surgery 133,6:814e-821e.
Hyman, D.M., Grisham, R.N. and Hensley, M.L. (2014). Management of advanced uterine
leiomyosarcoma. Current opinion in oncology 26,4:422-427.
Kerouanton, A., Jimenez, I., Cellier, C., et al. (2014). Synovial sarcoma in children and
adolescents. Journal of Pediatric Hematology/Oncology 36,4:257-262.
Luetke, A., Meyers, P.A., Lewis, I., et al. (2014). Osteosarcoma treatment - where do we
stand? A state of the art review. Cancer treatment reviews 40,4:523-532.
McCullough, A.L., Scotland, T.R., Dundas, S.R., et al. (2014). The impact of a managed
clinical network on referral patterns of sarcoma patients in Grampian. Scottish medical
journal 59,2:108-113.
Messina C. Ferreri AJ. Govi S. Bruno-Ventre M. Gracia Medina EA. Porter D. Radford J. Heo
DS. Park HY. Pro B. Jayamohan J. Visco C. Scarfo L. Zucca E. Gospodarowicz M. Christie D.
International Extranodal Lymphoma Study Group (I.E.L.S.G.). (2014). Clinical features,
management and prognosis of multifocal primary bone lymphoma: a retrospective study
of the international extranodal lymphoma study group (the IELSG 14 study). British journal
of haematology 164,6:834-840.
Prasad, S.C., D'Orazio, F., Medina, M., et al. (2014). State of the art in temporal bone
malignancies. Current Opinion in Otolaryngology & Head & Neck Surgery 22,2:154-165.
Radaelli, S., Stacchiotti, S., Casali, P.G., et al. (2014). Emerging therapies for adult soft
tissue sarcoma. Expert Review of Anticancer Therapy 14,6:689-704.
von Mehren, M., Randall, R.L., Benjamin, R.S., et al. (2014). Soft tissue sarcoma, version
2.2014. Journal of the National Comprehensive Cancer Network 12,4:473-483.
Weiss, A., Gill, J., Goldberg, J., et al. (2014). Advances in therapy for pediatric sarcomas.
Current oncology reports 16,8:395.
2
Combined Modality Therapies
Gronchi, A., De Paoli, A., Dani, C., et al. (2014). Preoperative chemo-radiation therapy for
localised retroperitoneal sarcoma: a phase I-II study from the Italian Sarcoma Group.
European journal of cancer 50,4:784-792.
Roeder, F., Lehner, B., Schmitt, T., et al. (2014). Excellent local control with IOERT and
postoperative EBRT in high grade extremity sarcoma: results from a subgroup analysis
of a prospective trial. BMC Cancer 14,350.
Schenone, A.D., Luo, J., Montgomery, L., et al. (2014). Risk-stratified patients with
resectable soft tissue sarcoma benefit from epirubicin-based adjuvant chemotherapy.
Cancer Medicine 3,3:603-612.
Sherman, K.L., Wayne, J.D., Chung, J., et al. (2014). Assessment of multimodality therapy
use for extremity sarcoma in the United States. Journal of surgical oncology 109,5:395-404.
Stucky, C.C., Wasif, N., Ashman, J.B., et al. (2014). Excellent local control with preoperative
radiation therapy, surgical resection, and intra-operative electron radiation therapy for
retroperitoneal sarcoma. Journal of surgical oncology 109,8:798-803.
Drug & Targeted Therapy
Ahmed, A.A., Zia, H. and Wagner, L. (2014). Therapy resistance mechanisms in Ewing's
sarcoma family tumors. Cancer Chemotherapy & Pharmacology 73,4:657-663.
Blay, J.Y., Leahy, M.G., Nguyen, B.B., et al. (2014). Randomised phase III trial of trabectedin
versus doxorubicin-based chemotherapy as first-line therapy in translocation-related
sarcomas. European journal of cancer 50,6:1137-1147.
Boye, K., Del Prever, A.B., Eriksson, M., et al. (2014). High-dose chemotherapy with stem
cell rescue in the primary treatment of metastatic and pelvic osteosarcoma: final results
of the ISG/SSG II study. Pediatric Blood & Cancer 61,5:840-845.
Bramswig, K., Ploner, F., Martel, A., et al. (2014). Sorafenib in advanced, heavily pretreated
patients with soft tissue sarcomas. Anti-Cancer Drugs 25,7:848-853.
Campana, L.G., Bianchi, G., Mocellin, S., et al. (2014). Electrochemotherapy treatment of
locally advanced and metastatic soft tissue sarcomas: results of a non-comparative
phase II study. World journal of surgery 38,4:813-822.
D'Angelo, S.P., Tap, W.D., Schwartz, G.K., et al. (2014). Sarcoma immunotherapy: past
approaches and future directions. Sarcoma 2014,391967.
Judson, I., Verweij, J., Gelderblom, H., et al. (2014). Doxorubicin alone versus intensified
doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue
sarcoma: a randomised controlled phase 3 trial. Lancet Oncology 15,4:415-423.
Kawaguchi, S., Sun, T., Lin, P.P., et al. (2014). Does ifosfamide therapy improve survival of
patients with dedifferentiated chondrosarcoma?. Clinical Orthopaedics & Related Research
472,3:983-989.
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Linch, M., Miah, A.B., Thway, K., et al. (2014). Systemic treatment of soft-tissue sarcomagold standard and novel therapies. Nature Reviews Clinical Oncology 11,4:187-202.
O'Donnell, P.W., Manivel, J.C., Cheng, E.Y., et al. (2014). Chemotherapy influences the
pseudocapsule composition in soft tissue sarcomas. Clinical Orthopaedics & Related
Research 472,3:849-855.
Palmerini, E., Paioli, A. and Ferrari, S. (2014). Emerging therapeutic targets for synovial
sarcoma. Expert Review of Anticancer Therapy 14,7:791-806.
Sun, L., Li, Y., Li, H., et al. (2014). Analysis of chemotherapy dosage and dosage intensity
and survival outcomes of high-grade osteosarcoma patients younger than 40 years.
Clinical therapeutics 36,4:567-578.
Turner, D.C., Navid, F., Daw, N.C., et al. (2014). Population pharmacokinetics of
bevacizumab in children with osteosarcoma: implications for dosing. Clinical Cancer
Research 20,10:2783-2792.
Wang, W., Wang, Z.C., Shen, H., et al. (2014). Dose-intensive versus dose-control
chemotherapy for high-grade osteosarcoma: a meta-analysis. European Review for
Medical & Pharmacological Sciences 18,9:1383-1390.
Pathology, Staging, Polymorphisms & Biomarkers
Doyle, L.A. (2014). Sarcoma classification: an update based on the 2013 World Health
Organization Classification of Tumors of Soft Tissue and Bone. Cancer 120,12:1763-1774.
Kang, S., Han, I., Lee, S., et al. (2014). Clinicopathological characteristics and prognostic
factors of T1 (5 cm) soft tissue sarcoma. European Journal of Surgical Oncology 40,4:406411.
Klijanienko, J., Colin, P., Couturier, J., et al. (2014). Fine-needle aspiration in desmoplastic
small round cell tumor: a report of 10 new tumors in 8 patients with clinicopathological
and molecular correlations with review of the literature. Cancer Cytopathology 122,5:386393.
Toulmonde, M., Bonvalot, S., Meeus, P., et al. (2014). Retroperitoneal sarcomas: patterns of
care at diagnosis, prognostic factors and focus on main histological subtypes: a
multicenter analysis of the French Sarcoma Group. Annals of Oncology 25,3:735-742.
Vormoor, B. and Curtin, N.J. (2014). Poly(ADP-ribose) polymerase inhibitors in Ewing
sarcoma. Current opinion in oncology 26,4:428-433.
Prognosis, Survival & Risk Factors
Biswas, B., Rastogi, S., Khan, S.A., et al. (2014). Outcomes and prognostic factors for
Ewing-family tumors of the extremities. Journal of Bone & Joint Surgery - American Volume
96,10:841-849.
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Brasme, J.F., Chalumeau, M., Oberlin, O., et al. (2014). Time to diagnosis of ewing tumors in
children and adolescents is not associated with metastasis or survival: a prospective
multicenter study of 436 patients. Journal of Clinical Oncology 32,18:1935-1940.
Kang, S., Kim, H.S., Kim, S., et al. (2014). Post-metastasis survival in extremity soft tissue
sarcoma: a recursive partitioning analysis of prognostic factors. European journal of
cancer 50,9:1649-1656.
Puri, A., Gulia, A., Hawaldar, R., et al. (2014). Does intensity of surveillance affect survival
after surgery for sarcomas? Results of a randomized noninferiority trial. Clinical
Orthopaedics & Related Research 472,5:1568-1575.
Putz, C., Gantz, S., Bruckner, T., et al. (2014). Preoperative scoring and limits of
prognostication: functional outcome after surgical decompression in metastatic spinal
cord compression. Oncology 86,3:177-184.
Sawamura, C., Matsumoto, S., Shimoji, T., et al. (2014). How long should we follow patients
with soft tissue sarcomas?. Clinical Orthopaedics & Related Research 472,3:842-848.
Radiotherapy & Imaging
Bagaria, S.P., Ashman, J.B., Daugherty, L.C., et al. (2014). Compliance with National
Comprehensive Cancer Network guidelines in the use of radiation therapy for extremity
and superficial trunk soft tissue sarcoma in the United States. Journal of surgical oncology
109,7:633-638.
Beane, J.D., Yang, J.C., White, D., et al. (2014). Efficacy of Adjuvant Radiation Therapy in
the Treatment of Soft Tissue Sarcoma of the Extremity: 20-year Follow-Up of a
Randomized Prospective Trial. Annals of Surgical Oncology 21,8:2484-2489.
Casey, D.L., Wexler, L.H., LaQuaglia, M.P., et al. (2014). Patterns of failure for
rhabdomyosarcoma of the perineal and perianal region. International journal of radiation
oncology, biology, physics 89,1:82-87.
Cheney, M.D., Giraud, C., Goldberg, S.I., et al. (2014). MRI surveillance following treatment
of extremity soft tissue sarcoma. Journal of surgical oncology 109,6:593-596.
Del Grande, F., Subhawong, T., Weber, K., et al. (2014). Detection of soft-tissue sarcoma
recurrence: added value of functional MR imaging techniques at 3.0 T. Radiology
271,2:499-511.
Hong, S.P., Lee, S.E., Choi, Y.L., et al. (2014). Prognostic value of 18F-FDG PET/CT in
patients with soft tissue sarcoma: comparisons between metabolic parameters. Skeletal
radiology 43,5:641-648.
Hurwitz, M.D., Ghanouni, P., Kanaev, S.V., et al. (2014). Magnetic resonance-guided focused
ultrasound for patients with painful bone metastases: phase III trial results. Journal of the
National Cancer Institute 106,5:
Jeon, D.G., Song, W.S., Cho, W.H., et al. (2014). Proximal tumor location and fluid-fluid
levels on MRI predict resistance to chemotherapy in stage IIB osteosarcoma. Clinical
Orthopaedics & Related Research 472,6:1911-1920.
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Joensuu, H., Reichardt, P., Eriksson, M., et al. (2014). Gastrointestinal stromal tumor: a
method for optimizing the timing of CT scans in the follow-up of cancer patients.
Radiology 271,1:96-103.
Kawaguchi, S., Weiss, I., Lin, P.P., et al. (2014). Radiation therapy is associated with fewer
recurrences in mesenchymal chondrosarcoma. Clinical Orthopaedics & Related Research
472,3:856-864.
le Grange, F., Cassoni, A.M. and Seddon, B.M. (2014). Tumour volume changes following
pre-operative radiotherapy in borderline resectable limb and trunk soft tissue sarcoma.
European Journal of Surgical Oncology 40,4:394-401.
Uhl, M., Mattke, M., Welzel, T., et al. (2014). High control rate in patients with
chondrosarcoma of the skull base after carbon ion therapy: first report of long-term
results. Cancer 120,10:1579-1585.
Wang, D. and Abrams, R.A. (2014). Radiotherapy for soft tissue sarcoma: 50 years of
change and improvement. American Society of Clinical Oncology Educational Book 244-251.
Zhao, F., Ahlawat, S., Farahani, S.J., et al. (2014). Can MR Imaging Be Used to Predict
Tumor Grade in Soft-Tissue Sarcoma?. Radiology 272,1:192-201.
Supportive Care & Symptom Management
Abate, M.E., Sanchez, O.E., Boschi, R., et al. (2014). Analysis of risk factors for central
venous catheter-related complications: a prospective observational study in pediatric
patients with bone sarcomas. Cancer nursing 37,4:292-298.
Cormie, P., Galvao, D.A., Spry, N., et al. (2014). Functional benefits are sustained after a
program of supervised resistance exercise in cancer patients with bone metastases:
longitudinal results of a pilot study. Supportive Care in Cancer 22,6:1537-1548.
DE Iuliis, F., Taglieri, L., Amoroso, L., et al. (2014). Prevention of osteonecrosis of the jaw in
patients with bone metastases treated with bisphosphonates. Anticancer Research
34,5:2477-2480.
Henry, D., Vadhan-Raj, S., Hirsh, V., et al. (2014). Delaying skeletal-related events in a
randomized phase 3 study of denosumab versus zoledronic acid in patients with
advanced cancer: an analysis of data from patients with solid tumors. Supportive Care in
Cancer 22,3:679-687.
King, E.A., Hanauer, D.A., Choi, S.W., et al. (2014). Osteochondromas after radiation for
pediatric malignancies: a role for expanded counseling for skeletal side effects. Journal of
pediatric orthopedics 34,3:331-335.
Muller, C., Winter, C., Boos, J., et al. (2014). Effects of an exercise intervention on bone
mass in pediatric bone tumor patients. International Journal of Sports Medicine 35,8:696703.
Tripathy, D., Durie, B.G., Mautner, B., et al. (2014). Awareness, concern, and communication
between physicians and patients on bone health in cancer. Supportive Care in Cancer
22,6:1601-1610.
6
Surgery
Anderson, M.E., Miller, P.E., van Nostrand, K., et al. (2014). Frozen section versus gross
examination for bone marrow margin assessment during sarcoma resection. Clinical
Orthopaedics & Related Research 472,3:836-841.
Angelini, A., Mavrogenis, A.F., Gambarotti, M., et al. (2014). Surgical treatment and results of
62 patients with epithelioid hemangioendothelioma of bone. Journal of surgical oncology
109,8:791-797.
Behnke, N.K., Alamanda, V.K., Song, Y., et al. (2014). Does postoperative infection after soft
tissue sarcoma resection affect oncologic outcomes?. Journal of surgical oncology
109,5:415-420.
Choi, E.S., Kim, H.S. and Han, I. (2014). Elevated preoperative systemic inflammatory
markers predict poor outcome in localized soft tissue sarcoma. Annals of Surgical
Oncology 21,3:778-785.
Chung, S.W., Han, I., Oh, J.H., et al. (2014). Prognostic effect of erroneous surgical
procedures in patients with osteosarcoma: evaluation using propensity score matching.
Journal of Bone & Joint Surgery - American Volume 96,8:e60.
Mundinger, G.S., Prucz, R.B., Frassica, F.J., et al. (2014). Concomitant upper extremity soft
tissue sarcoma limb-sparing resection and functional reconstruction: assessment of
outcomes and costs of surgery. Hand 9,2:196-204.
Muramatsu, K., Ihara, K., Tominaga, Y., et al. (2014). Functional reconstruction of the
deltoid muscle following complete resection of musculoskeletal sarcoma. Journal of
Plastic, Reconstructive & Aesthetic Surgery: JPRAS 67,7:916-920.
Wu, X., Wang, W., Meng, C., et al. (2014). Functional outcome of limb-salvage surgery with
shoulder abduction brace for bone tumors around the shoulders. Journal of surgical
oncology 109,7:714-720.
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