Oncogene

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Oncogenes and Onc-Gene
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Folder Title: Oncogene
Updated: April 15, 2010
OncTitle
Examples of Oncogenic RNA Viruses
(from Ruddon, 3rd Ed, Table 6.2)
Acute Transforming Viruses
Rous Sarcoma (non-defective)
Avian Erythroblastosis
Avian Myeloblastosis
Avian Myelocytomatosis
Abelson Leukemia
Harvey Sarcoma
Kirsten Sarcoma
Feline Sarcoma
Simian Sarcoma
Chicken Sarcoma
Chicken Leukemia
Chicken Leukemia
Chicken
Mouse Leukemia
Rat Sarcoma
Rat Sarcoma
Cat Sarcoma
Monkey Sarcoma
RNAOnc1
Examples of Oncogenic RNA Viruses
Acute Transforming Viruses
What Genetic Information Makes Them Oncogenic?
Rous Sarcoma
Avian Erythroblastosis
Avian Myeloblastosis
Avian Myelocytomatosis
Abelson Leukemia
Harvey Sarcoma
Kirsten Sarcoma
Feline Sarcoma
Simian Sarcoma
Extra Gene
src
Chicken Sarcoma
Chicken Leukemia erb
Chicken Leukemia myb
myc
Chicken
abl
Mouse Leukemia
Rat Sarcoma
Ha-ras
Rat Sarcoma
Ki-ras
Cat Sarcoma
fms
Monkey Sarcoma
sis
RNAOncG1
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Table 4.1 The Biology of Cancer (© Garland Science 2007). P. 100
Cell Site-of-action of Onc-Gene Products
(from Scientific American)
sis
OncLocus
Site of Action of Onc-Gene Products
Nucleus
• myc (N-myc, C-myc, Lmyc)
• myb
• fos
• ski
• jun
• erb-A
Receptor Tyr Kinases
• erb-B (EGF Receptor)
• erbB-2/neu (her-2/neu)
• met
• fms
• kit
• trk
Non-receptor Tyr-Kinase
• abl
• src
Ser/Thr Kinases
raf
PKC (Protein Kinase C)
GTP-Binding Proteins
Ha-Ras
N-Ras
K-Ras
Growth Factors
sis
int-2
hst
Others
B-lym
T-lym-1
bcl-1 (Cyclin D1)
bcl-2
OncSite
Questions About V-Onc Genes
Affecting the Biology of Cancer
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Where Does A Virus Get It From?
How Many Different V-Onc Genes Exist?
What Protein Does Each Code For?
What Do Those Proteins Do?
Where Do Those Proteins Do Their Thing?
Why Do They Cause Transformation?
How Do They Cause Transformation?
Do They Have a Normal function?
What Do They Tell Us About Neoplastic
Transformation Not Involving V-Onc Genes?
OncQues1
Alternative Ways in Which Oncogenes
Transform Cellular Gene Expression
• v-Onc Gene Insertion (Acutely
Transforming Retrovirus)
• Activation of c-onc Genes (Sub-acutely
transforming retroviruses and DNA viruses)
• Mutations in c-onc Genes
• Gene Rearrangements and Gene Fusions
Involving c-Onc Genes
• Amplification of c-Onc Genes
TransWay
Transfection of DNA from Transformed Cells into Normal Mouse Fibroblasts:
Figure 4.2 (part 1 of 2) The Biology of Cancer (© Garland Science 2007) p.
96
Determination of Transforming Ability of Transfected DNA Fragments
Figure 4.2 (part 2 of 2) The Biology of Cancer (© Garland Science 2007)
p. 96
Point Mutation Affecting Amino Acid 12 (Glycine) in H-RAS Gene Product in
Human Bladder Cancer
Figure 4.10 The Biology of Cancer (© Garland Science 2007)
Table 4.2 The Biology of Cancer (© Garland Science 2007) p. 106
In this picture, what is the purple stuff that is being
administered to the normal mouse fibroblasts?
You can identify it specifically or just generally.
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Amplification of Endogenous c-Oncogene in Human Cancer:
N-Myc in Human Neuroblastoma.
Figure 4.11b The Biology of Cancer (© Garland Science 2007) p. 107
Table 4.4 The Biology of Cancer (© Garland Science 2007) p. 111
Translocation and Chromosome Fusion in the Activation of
Endogeneous C-Oncogenes
Figure 4.15a The Biology of Cancer (© Garland Science 2007) p. 113
Fusion Oncoproteins in Human Malignancies; Bcr-Abl Fusion Proteins
CNL = Chronic neutrophilic leukemia
Figure 4.15b The Biology of Cancer (© Garland Science 2007)
p. 113
C-Abl part
Table 4.5 The Biology of Cancer (© Garland Science 2007)
p. 114
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Questions About c-Onc Genes
Affecting Prevention, Diagnosis, and
Treatment of Clinical Cancers
Can We Prevent Neoplastic Transformation
Based on Oncogene Effects?
Can We Use Oncogene Expression for
Diagnosis and Prognosis?
Can We Tailor Existing Treatments Based
on Oncogene Expression in a Patient?
Can We Develop New Treatments Based on
the Biochemistry of Oncogene Products?
OncQues2
c-Onc Genes Not Defined by V-Onc Gene Transfection from Viruses
c-Onc Genes Perturbed by retrovirus integration
int-1
int-2
MLV1-1
MLV1-2
Pim-1
Mouse mammary tumor virus
Mouse mammary tumor virus
Murine Leukemia Virus
Murine Leukemia Virus
Murine Leukemia Virus
Rat
Rat
Rat
c-Onc Genes Detected by DNA Transfection
N-ras
Neuroblastoma/leukemia/sarcomas
B-lym
B-cell lymphoma
mam
Mammary carcinomas
neu
Neuroblastoma/glioblastoma
cOncFind
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