Innovative treatment targets
In pediatric high-grade brain tumors
Dannis Gilbert van Vuurden
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Innovative treatment targets in pediatric high-grade brain tumors
Thesis, VU University, Amsterdam, the Netherlands
© Dannis van Vuurden, Amsterdam, the Netherlands, 2014
The printing of this thesis was supported by:
Actavis B.V.
Amgen B.V.
Becton Dickinson B.V.
Hospira Enterprises B.V.
Nutricia
Pfizer Oncology
Roche
Sanquin
Teva Pharmachemie B.V.
To-BBB Technologies B.V.
Cover
Els Custers (Based on a design by Esther Hulleman)
Lay-out Dorine Fliervoet
Printed by Buijten & Schipperheijn, Amsterdam
ISBN978-90-9028282-4
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VRIJE UNIVERSITEIT
Innovative treatment targets
in pediatric high-grade brain tumors
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad Doctor aan
de Vrije Universiteit Amsterdam,
op gezag van de rector magnificus
prof.dr. F.A. van der Duyn Schouten,
in het openbaar te verdedigen
ten overstaan van de promotiecommissie
van de faculteit der Geneeskunde
op dinsdag 17 juni 2014 om 15:45 uur
in de aula van de universiteit,
De Boelelaan 1105
door
Dannis Gilbert van Vuurden
geboren te Arnhem
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Promotoren:
Prof. dr. G.J.L. Kaspers
Prof. dr. W.P. Vandertop
Co-promotoren: Dr. J. Cloos
Dr. E. Hulleman
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Contents
Chapter 1 General introduction and outline of this thesis
7
Adapted from ‘Hersentumoren op kinderleeftijd’, Tijdschrift voor Kindergeneeskunde 2011; 79: 146-155
Chapter 2 Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment
PLoS ONE 2009; 4(6): e5953
23
Chapter 3 PARP inhibition sensitizes childhood high-grade glioma,
medulloblastoma and ependymoma to radiation
Oncotarget 2011; 2(12): 984 – 996
41
Chapter 4 Cytotoxicity and radiosensitization of high-grade glioma
cells by CI-1033, an irreversible pan-ErbB inhibitor
Journal of Cancer Science & Therapy 2013; 5(7): 249-255
63
Chapter 5 PBXIP1 is overexpressed in astrocytoma and promotes
tumor cell growth and migration
Neuro-Oncology; In press
83
Chapter 6
Epigenetic silencing of SIRPα in medulloblastoma
To be submitted
113
Chapter 7
Summary / Samenvatting
137
Chapter 8
Appendices
General discussion and future directions
145
Publications
157
Dankwoord
Curriculum Vitae
163
171
Figures in color
167
5
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I just know that something good is going to happen...
Kate Bush
(Cloudbusting, 1985)
6
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