Cover Page
The handle http://hdl.handle.net/1887/24412 holds various files of this Leiden University
dissertation
Author: Willemse, Peter-Paul M.
Title: Skeletal and metabolic complications of testicular germ cell tumours
Issue Date: 2014-03-06
Skeletal and Metabolic Complications
of Testicular Germ Cell Tumours
Peter-Paul Michiel Willemse
Colophon
Skeletal and Metabolic Complications of Testicular Germ Cell Tumours.
PhD-Thesis, University of Leiden, The Netherlands.
Copyright © 2014 Peter-Paul Michiel Willemse, Rotterdam, The Netherlands.
All rights are reserved. No part of this publication may be reproduced or transmitted in any
form or by any means, electronic or mechanical, including photocopy, recording, or any
information storage or retrieval system without permission of the author or the publisher of
the included scientific papers.
ISBN/EAN: 978-90-5335-804-7
Cover design: P.M. Willlemse
Lay out: Buro Gom, Arnhem, the Netherlands
Printed by: Ridderprint BV, Ridderkerk, the Netherlands
The publication of this thesis was supported by: the Department of Clinical Oncology of
the LUMC, Abbvie B.V., Amgen B.V., Astellas B.V., GlaxoSmithKline, Janssen-Cilag B.V. and
Pfizer B.V.
Cover-illustratie:
Meridiaankogels, in het Engels “Boading balls” of “Chinese health balls” genoemd, zijn Chinese
massagekogels. Ze staan bekend als één van de “drie schatten van Boading” en stammen uit
de tijd van de Ming-dynastie (1368-1644). Meridiaankogels werden oorspronkelijk vervaardigd
uit hout, metaal of mineralen, zoals Jade. Volgens de klassieke Chinese geneeskunde zijn alle
vitale organen via energiebanen (meridianen) met de vingertoppen verbonden en kunnen zo
worden gestimuleerd.
Skeletal and Metabolic Complications
of Testicular Germ Cell Tumours
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op donderdag 6 maart 2014
klokke 16:15 uur
door
Peter-Paul Michiel Willemse
geboren te Rotterdam
in 1978
Promotie Commissie
Promotores
Prof. Dr. S. Osanto
Prof. Dr. J. Burggraaf
Co-promotor Dr. N.A.T. Hamdy
Overige leden Prof. Dr. F.R. Rosendaal
Prof. Dr. C.H. Bangma, Erasmus Universiteit Rotterdam
Prof. Dr. J.H.M. Schellens, Universiteit Utrecht
Table of contents
Chapter 1 General Introduction and outline of the thesis
7
Chapter 2Prevalence of metabolic syndrome and cardiovascular disease in
chemotherapy-treated testicular germ cell tumour survivors.
Br J Cancer. 2013
21
Chapter 3Abdominal visceral and subcutaneous fat increase, insulin
resistance and hyperlipidemia in testicular cancer patients treated
with cisplatin-based chemotherapy. Acta Oncol. 2013
39
Chapter 4Chemotherapy for testicular cancer induces acute alterations in
diastolic heart function. Br J Cancer. 2013
59
Chapter 5Cisplatin-based chemotherapy increased serum iron and nontransferrin bound iron in patients treated for testicular cancer.
Submitted
71
Chapter 6Prevalence of vertebral fractures independent of BMD and anticancer treatment in patients with testicular germ cell tumours.
J Clin Endocrinol Metab. 2010
87
Chapter 7Natural history of changes in bone mineral density in newly
diagnosed testicular cancer patients after anti-cancer treatment.
105
Chapter 8 Summary and general discussion
125
Chapter 9 Dutch summary
135
Appendices
References
Abbreviations
Acknowledgements
Curriculum Vitae
List of publications
143
144
156
161
163
164