Cover Page
The handle http://hdl.handle.net/1887/28524 holds various files of this Leiden University
dissertation
Author: Djaberi, Roxana
Title: Cardiovascular risk assessment in diabetes
Issue Date: 2014-09-04
Cardiovascular Risk Assessment
in Diabetes
Roxana Djaberi
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The studies described in this thesis were performed at the Department of Cardiology of
the Leiden University Medical Center, Leiden, the Netherlands.
Cover design: Katherine Kudo, Kudo Design, New Zealand
Layout: Gildeprint, Enschede, The Netherlands
Printed by: Gildeprint, Enschede, The Netherlands
ISBN: 978-94-6108-731-7
Copyright © 2014 Roxana Djaberi, Leiden, the Netherlands. All rights reserved. No parts
of this book may be reproduced or transmitted in any form or by any means, without
prior written permission of the copyright author.
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Cardiovascular Risk Assessment
in Diabetes
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties ter verdedigen
op donderdag 4 september 2014, klokke 15.00 uur
door
Roxana Djaberi
geboren te Teheran, Iran
in 1979
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Promotiecommissie
Promotores:
prof. dr. J.W. Jukema
prof. dr. J.J. Bax
Co-promotor: dr. J.H.A. Scholte
Overige leden: dr. P.R.M. van Dijkman (Bronovo ziekenhuis)
prof. dr. A.M. Pereira
prof. dr. A.J. Rabelink
prof. dr. C.J. Tack (Radboud Universitair Medisch Centrum)
Financial support by the Netherlands Heart Foundation and the Interuniversity
Cardiology Institute of the Netherlands for the publication of this thesis is gratefully
acknowledged.
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For my parents
To Philip and little Mira
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Table of contents
Chapter 1 General introduction
Part I
Coronary artery disease in adiposity and in diabetes
Chapter 2
Relation of epicardial adipose tissue to coronary atherosclerosis
Am J Cardiol 2008; 102:1602-1607
Chapter 3Reduced plasma adiponectin is associated with extent, degree
and morphology of coronary artery disease in asymptomatic
patients with type 2 diabetes
11
25
39
Submitted
Chapter 4
ifferences in atherosclerotic plaque burden and morphology
D
between type 1 and 2 diabetes as assessed by multislice
computed tomography
63
Diabetes Care 2009; 32:1507-1512
Chapter 5
ndothelial dysfunction in diabetic patients with abnormal
E
myocardial perfusion in the absence of epicardial obstructive
coronary artery disease
79
J Nucl Med 2009; 50:1980-1986
Part II
Cardiovascular risk assessment in diabetes
Chapter 6Non-invasive cardiac imaging techniques and vascular tools
for the assessment of cardiovascular disease in type 2 diabetes
mellitus101
Diabetologia 2008; 51:1581-1593
Chapter 7
sefulness of carotid intima-media thickness in patients with
U
diabetes mellitus as a predictor of coronary artery disease
129
Am J Cardiol 2009; 104:1041-1046
7
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Table of contents
Chapter 8
I ncreased carotid intima-media thickness as a predictor of
the presence and extent of abnormal myocardial perfusion in
type 2 diabetes
145
Diabetes Care 2010; 33:372-374
Chapter 9
elationship between vascular stiffness and stress myocardial
R
perfusion imaging in asymptomatic patients with diabetes
155
Eur J Nucl Med Mol Imaging 2011; 38:2050-2057
Chapter 10
I ncremental value of coronary artery calcium score over microalbuminuria to predict myocardial ischemia in asymptomatic
patients with type 1 diabetes
173
Submitted
Chapter 11
omparative performance of risk stratification tools for
C
predicting functionally relevant coronary artery disease in
asymptomatic type 2 diabetes
191
Submitted
Part IIIMicrovascular disease
Chapter 12
on-invasive assessment of microcirculation by sidestream
N
dark field imaging as a marker of coronary artery disease in
diabetes209
Diab Vasc Dis Res 2013; 10:123-134
Summary and Conclusions
231
Samenvattingen en Conclusies
239
Publications247
Acknowledgements251
Curriculum Vitae 253
8
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