Cover Page
The handle http://hdl.handle.net/1887/25760 holds various files of this Leiden University
dissertation
Author: Vaarhorst, Anika
Title: Genetic and metabolomic approaches for coronary heart disease risk prediction
Issue Date: 2014-05-13
Genetic and metabolomic approaches
for coronary heart disease risk prediction.
Anika Antoinette Maria Vaarhorst
Genetic and metabolomic approaches for coronary heart disease risk prediction.
Drs. Anika A.M. Vaarhorst
PhD thesis with summary in Dutch
ISBN: 978-90-8891-869-8
Cover design:
Printed & Lay Out by: Published by:
Proefschriftmaken.nl || Uitgeverij BOXpress
Proefschriftmaken.nl || Uitgeverij BOXpress
Uitgeverij BOXpress, ’s-Hertogenbosch
Genetic and metabolomic approaches
for coronary heart disease risk prediction.
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College van Promoties
te verdedigen op dinsdag 13 mei 2014
Klokke 16.15 uur
door
Anika Antoinette Maria Vaarhorst
Geboren te Enschede
in 1981
Promotiecommissie
Promotor:
Prof. Dr. P. Slagboom
Co-promotor:
Dr. B.T. Heijmans
Overige leden: Prof. Dr. H. Putter
Prof. Dr. E.J.M. Feskens
Wageningen University
Prof. Dr. Y.T. van der Schouw
University Medical Center Utrecht
The research described in this thesis was supported by a grant of the Dutch Heart
Foundation (DHF-2006B195) and by BBMRI-NL, a Research Infrastructure financed by the
Dutch government (NWO 184.021.007).
Financial support by the Dutch Heart Foundation for the publication of this thesis is
gratefully acknowledged. Financial support for the printing of this thesis was provided by
the Netherlands Consortium for Healthy Ageing (GI 050060810).
Contents
Chapter 1
General Introduction
7
Chapter 2
A metabolomics profile is associated with the risk of incident coronary heart disease
21
Chapter 3
CHD risk prediction using regularized Cox regression: Comparing a targeted and an untargeted approach for
extracting information from 1H-NMR spectra
37
Chapter 4
Lipid metabolism in long-lived families: The Leiden Longevity Study
49
Chapter 5
Literature-based genetic risk scores for coronary heart
disease; the CAREMA prospective-cohort study
63
Chapter 6
Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort Study
81
Chapter 7 Summary and general discussion
97
Chapter 8
Nederlandse samenvatting
111
Supplement I
Supplement II
Supplement III
Supplement IV
Dankwoord
Curriculum Vitae
List of publications 119
131
133
155
161
163
165
5
6