Cover Page
The handle http://hdl.handle.net/1887/23446 holds various files of this Leiden University
dissertation.
Author: Boven, Wim Jan P. van
Title: Organ injury after coronary bypass grafting : a biomarker study towards optimal
surgical strategy
Issue Date: 2014-02-06
Organ Injury after
Coronary Artery
Bypass Grafting
A biomarker study towards optimal surgical strategy
Wim Jan van Boven
Dit proefschrift werd mede mogelijk gemaakt door:
Financieel: Sorin Group, St. Jude Medical, Medtronic, Cardicac Care, Maquet, Biotronik, Covidien, Edwards lifesciences, Sanofi, LST Europe, Atricure Inc.
Omslag ontwerp: Aat Marinissen
Druk: Drukkerij Gildeprint, Enschede
Layout en grafische vormgeving: Crevi, dtp-ontwerpstudio, de Bilt
ISBN: 000-00-0000-000-0
Organ Injury after
Coronary Artery
Bypass Grafting
A biomarker study towards optimal surgical strategy
Proefschrift
ter verkrijging van de graad van doctor
aan de Universiteit Leiden,
op gezag van Rector Magnificus
prof. dr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties
te verdedigen op
donderdag 6 februari 2014, klokke 11.15 uur
door
Wim Jan P. van Boven
geboren te Rotterdam
op 22 mei 1959
Promotiecommissie:
Promotores:
Prof. dr. R.J.M. Klautz
Prof. dr. L.P.H.J. Aarts
Promotie commissie:
Prof. dr. M.J. Schalij
Prof. dr. J.G. Maessen, Maastricht
Prof. dr. B. Preckel, Amsterdam
I shall be telling this with a sigh
Somewhere ages and ages hence:
Two roads diverged in a wood, and II took the one less traveled by,
And that has made all the difference.
Robert Frost
Contents
Contents
1. Introduction
13
1.1 Background
15
1.2 History of coronary artery bypass grafting (CABG)
16
1.3 Mechanisms of organ injury during CABG
18
1.3.1 Ischemia related
18
1.3.2 Non-ischemia related
21
1.4 Optimal extracorporeal support for CABG
22
1.5 Optimal myocardial preservation
23
1.6 Changing demographics and impact on resources
25
1.7 Aim of this thesis
27
1.8 Outline of this thesis
27
2. Impact of type and technique on resources in elderly CABG patients
A retrospective comparison between Minimized circuit CABG, OPCAB and
Conventional on- pump CABG
3. Biomarkers indicating global and organ-specific injury
91
Perfusion 2004 Jul: 19 (4): 239-246
6. Malondialdehyde in plasma, a biomarker of global oxidative
stress during mini CABG compared to on-pump and off-pump
CABG surgery. A pilot study
71
Eur J Cardio-Thorac Surg 2001 Nov; 20 (5): 923-929
5. Mini-extracorporeal circuit coronary artery bypass grafting:
initial clinical and biochemical results
53
Review
4. Off-pump versus on-pump coronary artery bypass grafting:
oxidative stress and renal function
35
Interact CardioVasc Thorac Surg 2006 Feb; 5 (1): 27-31
111
7. Pneumoproteins as a lung-specific biomarker of alveolar
permeability in conventional on-pump CABG versus Mini-ECC,
A Pilot Study
Chest 2005 Apr; 127 (4): 1190-1195
8. Myocardial oxidative stress and cell injury comparing three different techniques for coronary artery bypass grafting
127
143
Eur. j. Cardio-thor. Surg. 2008 Nov;34(5):969-75
9. Minimised closed-circuit coronary artery bypass grafting in the
elderly is associated with lower levels of organ-specific biomarkers.
A prospective randomized study
163
European Journal of Anesthesia 2013 Nov; 30 (11): 685-94
10. Impact of surgical strategy related haemodilution on perioperative
S100β protein release in elderly CABG patients 187
Innovations 2013 (Phila) 2013 May-Ju; 8 (3):230-6
11. General discussion and conclusion
207
12. English Summary
Dutch Summary
221
227
13. Curriculum vitae
233
14. Dankwoord
239