Cover Page
The handle http://hdl.handle.net/1887/26936 holds various files of this Leiden University
dissertation
Author: Schmitz, Frederike
Title: Intraepithelial lymphocytes in refractory celiac disease : lost in transition
Issue Date: 2014-06-19
Intraepithelial Lymphocytes in
Refractory Celiac Disease:
Lost in Transition
Intraepithelial Lymphocytes in Refractory Celiac
Disease:
Lost in Transition
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezaag van Rector Magnificus prof. mr. C.J.J.M.
Stolker, volgens besluit van het College voor
Promoties ter verdedigen op
donderdag 19 juni 2014
klokke 16:15
door
Frederike Schmitz
geboren te Göttingen in 1982
PROMOTIECOMISSIE
Promotor: Prof. Dr. F. Koning
Copromotor: Dr. J. van Bergen
Overige leden: Prof. Dr. C.J.J. Mulder Vrije Universiteit Amsterdam
Prof. Dr. H. Spits Academisch Medisch Centrum Amsterdam
Dr. J.N. Samsom Erasmus MC Rotterdam
The studies described in this thesis were performed at the Department of
Immunohematology and Blood Transfusion, Leiden, Leiden University Medical Center.
This work was financially supported by the Celiac Disease Consortium, an Innovative
Cluster approved by The Netherlands Genomics Initiative and partially funded by the
Dutch government (BSIK03009).
Financial support for the publication of this thesis was provided by the Nederlandse
Coeliakie Vereniging. The Nederlandse Coeliakie Vereniging supports scientific
research.
Also, the NCV organizes contacts amongst fellow-sufferers, offers and spreads
information, informs and is active in advocacy for persons with coeliac disease or
dermatitis herpetiformis (www.glutenvrij.nl).
Printing: Gildeprint
ISBN: 978-94-6108-665-5
Layout: Amelie Knura and Frederike Schmitz
Cover: Frederike Schmitz
© Frederike Schmitz 2014
All rights reserved. No part of this publication may be reproduced or transmitted in
any form or by any means, electronic or mechanical, including photocopy, recording,
or any information storage and retrieval system, without permission from the author.
CONTENTS
Chapter 1
General introduction, chapter outline and
scope of the thesis
10
chapter 2
DENDRITIC CELLS PROMOTE EXPANSION AND
SURVIVAL OF ABERRANT TCR-NEGATIVE INTRAEPITHELIAL LYMPHOCYTE LINES FROM REFRACTORY
CELIAC DISEASE TYPE II PATIENTS
38
chapter 3
Identification of a potential physiological
precursor of aberrant cells in refractory
coeliac disease type II
58
chapter 4
cELIAC AND REFRACTORY CELIAC DISEASE
ALTER THE COMPOSITION OF THE INNATE
INTRAEPITHELIAL LYMPHOCYTE COMPARTment AND
ITS DIFFERENTIATION POTENTIAL
86
chapter 5
human CD34-Cd103+lineage-cd127- thymocytes
harbor bipotential t/nk cell precursors
114
Chapter 6
general discussion
nederlandse samenvatting
curriculum vitae, list of publications
130