Differentiating Between Major Types of Foodborne Diseases Microbiological hazards cause most foodborne diseases in the U.S. The three microbiological hazards of concern are bacteria, viruses, and parasites. These microorganisms can cause one of three types of illness –infection, intoxication, or toxin-mediated infection. Type of Illness Infection Intoxication Toxin-Mediated Infection Causes Forms Happens when a person eats food containing harmful microorganisms, which then grow in the intestinal tract and cause illness. Happens when a person eats food containing toxins that cause illness. Usually a result of chemical contamination Happens when a person eats food containing harmful bacteria; while in the intestinal tract, the bacteria produce toxins that cause illness. Some bacteria (Salmonella, Listeria, Vibrio Vulnificus) All Viruses All Parasites Some bacteria (Botulism, Staph, Bacillus Cereus, and Clostridium perfringens) No viruses or parasites Some bacteria (shigella, and e. coli) No viruses or parasites