Global Mental Health: Focus on Latino Populations Javier I Escobar MD Associate Dean for Global Health and Professor of Psychiatry and Family Medicine, UMDN-Robert Wood Johnson Medical School September 2011 Local Health International Health Global Health GLOBAL HEALTH “Health problems, issues, and concerns transcend national boundaries, may be influenced by circumstances or experiences in other countries, and are best addressed by cooperative actions and solutions.” The Institute of Medicine US Commitment to Global Health • The President asked congress to spend $ 63 billion over the next six years on a broader Global Health strategy that would reshape previous policy. • According to the President, this US global health investment is an important component of the national security “smart power strategy”, where the power of America’s development tools can build the capacity of government institutions and reduce the risk of conflict before it gathers strength. • It has been also recommended that Global Health should become the pillar of US Foreign Policy* *Institute of Medicine report released on 12/22/2008 We are in a Global Age US Medical Schools are developing programs in Global Health (Harvard, Johns Hopkins, Michigan, NYU and many others) NIH Institutes opening Global Health’s Offices. Major Universities require significant time abroad for undergraduates (Harvard, Princeton, etc.). “If you are going to come to Harvard College it would be very good to have a passport” William Kirby, Dean of the Faculty of Arts and Sciences (Guardian Unlimited, April 27, 2004) NIH AND GLOBAL HEALTH • The new director of NIH, Francis Collins, listed Global Health as one of his top four priorities at the Institute • Collins plans to expand research efforts to include diseases endemic to developing nations and increase research collaboration with those countries, to alter the world’s view of the United States, “by emphasizing its role as a doctor rather than a soldier” NIMH INTERNATIONAL ACTIVITIES In 2004, there were 184 NIMH-funded research projects that included an international component, only a handful of these (5 or less) taking place in Latin America. By 2009, the director reported that there were 200 projects with an international component. In 2010, first RFA to create “International Hubs” (one of them in Latin America) In 2011, second RFA for “International Hubs”* *We are submitting application that includes UMDNJ and sites in Colombia, Mexico, Argentina and Peru. US Medical Schools and Hospitals Expanding Overseas Weill Cornell Medical Center: Cornell Medical School in Qatar Duke University: Duke Medical School in Singapore Johns Hopkins: Two Hospitals in the United Arab Emirates and one in Singapore Cleveland Clinic: Hospital in Abu Dhabi University of Pittsburgh (UPMC): Oncology centers in Greece, Turkey, Germany, South Korea Why “Global Health” in Places Like New Jersey or Zaragoza Spain? Latinos in New Jersey 400,000 350,000 300,000 250,000 200,000 150,000 100,000 50,000 0 ns ans ans ians ans ans ians rans lans rans a c b c ic ri b u x o ni uv ado ema ndu Ri i m e r d C o M olo ua Pe alv uat re to Dom H c C S E G Pu Source : U.S. Census, 2000 Latinos in New Brunswick 48% of all residents 30 25 20 26 23 18 15 10 5 8 7 7 7 3 0 o n n n a n a a i c c c t i i a Ri in er L o m M o er rt Am e h D t S O Pu C/ n ci a ex Source: New Brunswick Community Health Survey, Center for State Health Policy, 2004 B ck la W hi te Al th O l er Latinos in New Brunswick Mexican C/S American Dominican Puerto Rican Not US citizen 84% 63% 62% 0 Spanish at home 99% 87% 94% 51% Adult uninsured 70% 51% 39% 23% Adult MH (fair/poor) 41% 23% 43% 25% Anxiety symptoms 6% 11% 8% 10% Depression symptoms 12% 13% 13% 22% Source: New Brunswick Community Health Survey, Center for State Health Policy, 2004 Country Origin of Latino Patients Recruited in a Primary Care Study at Eric B. Chandler Clinic, in New Brunswick (Escobar J.I., et al Annals of Family Medicine, 2007) 44% 13% 1.2% ub a 1.2% Pe ru 12% C rg e Ri ca 2.4% A C ra g ic a N os ta or ua 4.7% ad SA 4.8% U ol om bi a H on du ra Pu s er to R ic o ep . C om .R D M ex ic o 5% nt in a 3.5% 8% Ec u 9% Concentration of Foreign-born Immigrants in Zaragoza Delicias, Casco Viejo A. Fullaondo, P. Garcia, www.enhr2007rotterdam.nl Immigrants in Zaragoza (2006) Argelia China 4% 4% Colombia 7% Rumania 24% Marruecos 8% Ecuador 17% Otros Varios 36% Total Population = 660,895 Immigrants = 65,012 Immigrants in Zaragoza, Spain Zaragoza = the smallest among Spanish Metropolis. 2001 = 14,583 (2%) 2005 = 53,492 (8%) 2006 = 65,012 (10%) 2008 = 92,491 (12%) 2010 = 108,373 (>15%) Immigrants account for >90 % of the demographic growth in the city. More than one fourth of all immigrants come from Ecuador and Colombia. Other immigrant groups (Asians and other Europeans) have been on the increase recently. Most Important Global Health Problems Nowadays Communicable, Maternal, Perinatal and Nutritional Conditions Non-communicable Diseases (Chronic Diseases; Mental Disorders) Injuries Other (Obesity, Violence, etc.) LIFE EXPECTANCY AND INCOME THE WORLDWIDE BURDEN HISTORY OF EMERGING INFECTIONS YEAR 610 644 900 1348 1495 1510 1546 1557 1567 DISEASE Influenza Leprosy Smallpox Plague Syphilis Scarlet Fever Typhus Malaria Smallpox History of Emerging Infections 1973 1977 1977 1981 1982 1983 1983 1991 1991 1994 1998 1999 2001 2003 2006 Rotavirus Ebola Virus Legionnaire’s Disease Toxic Shock Syndrome Lyme Disease HIV-AIDS Helicobacter Pylori Multi Drug Resistant (MDR) TB Epidemic Cholera Cryptosporidium Hong-Kong Bird Flu West Nile Virus Anthrax SARS Extremely Drug Resistant (XDR) TB) West Nile Virus in the US WNV Activity 9/04 T=1386 Deaths 35 AIDS Pandemic AIDS undoubtedly was one of the most devastating diseases that emerged during the 20th century. o From 1981 to the end of 2004, about 25 million people world-wide have succumbed to HIV infections. o The pandemic is expected to progress well into the 21th century. o Influenza An agent of great concern globally is influenza virus. Influenza virus is known to cause epidemics as early as the 1500’s, and pandemics have been described as early as 1889. The most extensive pandemic ever known is the pandemic of influenza of 1918-1919, which killed more 20 million people. Ref Business Week, April 14, 2003 Malaria Trachoma Trachoma is an infectious eye disease. the result of infection of the eye with Chlamydia trachomatis. Trachoma is the leading cause of blindness in the world (Africa, China, Thailand, Mexico, Brazil, Ecuador). In the USA = Native Americans and the Appalachian Region • Globally, 84 million people suffer from active infection and nearly 8 million people are visually impaired as a result of this disease. ... Trachoma Infection spreads from person to person, and is frequently passed from child to child and from child to mother, especially where there are shortages of water, numerous flies, and crowded living conditions. Infection often begins during infancy or childhood and can become chronic. If left untreated, the infection eventually causes the eyelid to turn inwards, which in turn causes the eyelashes to rub on the eyeball, resulting in intense pain and scarring of the front of the eye. This ultimately leads to irreversible blindness, typically between 30and 40 years of age. WHO’s SAFE Surgery Antibiotics Facial Cleansing Enhanced Hygiene NCS in the Global Front • Most people nowadays die from noncommunicable diseases (NCS) once associated with wealth such as cancer, heart diseases, diabetes, etc. • In 2008, 36 million deaths or 63% of all deaths worldwide, were due to NCS. • In late September 2011 a high level summit of the United Nations will be addressing this problem Complex Global Health Problems: Mental Disorders Addiction Obesity Violence Injuries Leading Causes of Disability Around The World (Cost in Billions of US Dollars) Schizophrenia Arthritis Congenital Defects Bipolar COPD Alcohol Falls Anemia $0.00 $10.00 $20.00 World Health Organization, 1996 $30.00 Depression $40.00 $50.00 Obesity Violence Addiction DALYs Lost Due to High-Risk Drinking by Disease Category and Region (2001) 11.8 9.7 Injury 12.0 1.5 Millions of DALYs 6.8 8.0 3.1 1.5 4.0 6.5 5.3 Chronic Disease 5.6 4.5 10.3 3.7 1.7 1.1 0.5 3.2 2.8 4.5 0.0 Europe/ Central Asia Latin SubAmerica/ Saharan Caribbean Africa E. Asia/ Pacific South Asia Notes: Numbers are rounded. Source: Disease Control Priorities in Developing Countries, second edition, 2006, Table 47.3 HighIncome Countries The WHO ranking of the world’s health care systems 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. France Italy San Marino Andorra Malta Singapore Spain Oman Austria Japan Norway Portugal Monaco Greece Iceland Luxembourg Netherlands United Kingdom WHO Health Report, 2000 19. Ireland 20. Switzerland 21. Belgium 22.Colombia 23. Sweden 24. Cyprus 25. Germany 26. Saudi Arabia 27. United Arab Emirates 28. Israel 29. Morocco 30. Canada 31. Finland 32. Australia 33.Chile 34. Denmark 35. Dominica 36.United States of America Total Health Expenditures as % of GDP, 2002-2005 1. Marshall Islands (19%) 2. USA (>14%) 3. Niue 4. Timor-Leste 5. Micronesia 6. Kiribati 7. Maldives 8. Malawi 9. Switzerland 10. France (10%) 11. Germany (10%) 40.Spain (7-8%) 41. United Kingdom (78%) 60.Colombia (7-8%) Source = WHO Disability Adjusted Life Expectancy at Birth 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. Japan Australia France Sweden Spain Italy Greece Switzerland Monaco Andorra San Marino Canada Source, WHO, 1999 13. Netherlands 14. United Kingdom 15. Norway 16. Belgium 17. Austria 18. Luxembourg 19. Iceland 20. Finland 21. Malta 22. Germany 23. Israel 24. United States of America RWJMS Office of Global Health Located at CAB Suite 7038 o Javier I Escobar MD, Associate Dean for Global Health o Aparna Kalbag MD, PhD, Post Doctoral Fellow o Rachel Werner, Administrative Assistant o Steering Committee: Sunanda Gaur MD (Pediatrics), Robert Like MD; Sonia Garcia-Lambauch MD; Karen Lin MD (Family Medicine), Charletta Ayers MD (OB & Gyn); Abel Moreyra MD (Medicine/Cardiology), Shannon O’Hearn MS3, Minyoung Yang MS3, Peter Murr MS-2, Rhea Itoop MS-2, Shazia Mehmood MS-2 RWJMS Medical Students’ Interest in Global Health o o o 21% of RWJMS 2012 Class Were Born Outside the United States Over 20 students in the entering class have participated in international service activities prior to medical school on four different continents Over 1/3 of first year medical students express interest in having an international experience during medical school LATIN AMERICA: COLOMBIA --CES Medical School, Medellín --Universidad de Antioquia, Medellín --Universidad de los Andes, Bogota (Dr. Javier I Escobar) BRAZIL --Brazil, Cross Cultural project with Pediatrics (Dr. Moorthy); --Universidad de Sao Paulo (Dr. Pat Williams, Pediatrics) ARGENTINA --Universidad de la Plata (Dr. Abel Moreyra Medicine/Cardiology) --Universidad de Buenos Aires; Departamento de Salud, San Salvador de Jujuy MEXICO --Instituto Mexicano de Psiquiatria --Universidad Popular Autónoma del Estado de Puebla (UPAEP) --Universidad de Oaxaca PERU --Universidad Cayetano Heredia, Lima COSTA RICA --International Health Central American Institute Foundation , San José ABOUT 50 RWJMS MEDICAL STUDENTS WENT ABROAD IN 2008-2009 60% = MS-II 25% = MS-III 15% = MS-IV COUNTRIES VISITED ZAMBIA DOMINICAN REPUBLIC MYANMAR COSTA RICA GHANA ARGENTINA SPAIN CHINA SOUTH AFRICA SWITZERLAND TIBET INDIA GUATEMALA MEXICO ECUADOR COLOMBIA HIMALAYAS/NEPAL “RWJMS HAS GONE GLOBAL” OPPORTUNITIES AND RESOURCES FOR INTERNATIONAL MENTAL HEALTH RESEARCH Collaborations with Latin America: Javier I Escobar MD Addiction in the Americas (CICAD - OAS) Collaboration with Costa Rica, Mexico, Barbados, Uruguay, El Salvador, Chile, Colombia (UMDNJ-RWJMS as Coordinating Site) NIMH/CIR/PAHO: Collaboration in Mental Health Services Research and Education (USA, Canada, Mexico, Colombia, Chile, Brazil, Peru, Jamaica) NIMH-Funded Genetic Study: “Bipolar Endophenotypes in Population Isolates” – UCLA, Colombia, Costa Rica NIMH R-13 Mentoring Grant “Critical Research Issues in Latino Mental Health” Schizophrenia Study in Argentina. Outcome of Schizophrenia Across Cultures (WHO Study-- Jablensky et al, 1992) Best Outcome Worst Outcome 40 20 s rh u Aa ue Pr ag on nd Lo W as hi ng to n w co M os al i C n da Ib a Ag ra 0 Familial Expressed Emotion and Relapse of Schizophrenia • 26 Studies in Several 600 Countries (England, USA, Spain, Germany, Eastern Europe, Japan, relapsed did not relapse 500 400 300 Mexico) • Percent Relapsing: Low EE -- 22% High EE -- 50% 200 100 0 Low EE High EE AVAILABLE DATA SETS World Mental Health Surveys Participating Countries in the Americas Country Brazil Canada Colombia Costa Rica Mexico Peru United States Sample Size 5,000 30,000 5,000 5,000 5,000 5,000 25,000 52 World Mental Health Surveys Participating Countries Legend Participating countries Pending countries No Data The boundaries and names shown and the designations used on this map do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate border lines for which there may not yet be full agreement. WHO 2003. All rights reserved Use of Cannabis and Cocaine in Several Countries USA Canada Mexico South America 10 8 6 4 2 0 Marihuana Medina Mora et al, 2005 Cocaine Asia HEALTH DISPARITIES Diagnostic disparities Let’s remember the old USA/UK Study inspired by the Schizophrenias that “were cured just by crossing the Atlantic” (From the US to England)! --This led to structured instruments and diagnoses to diminish bias ---However, diagnostic bias is here to stay!-- UBHC STUDY (N=19,219) Percent With Serious Mental Illness (Dementia, Schizophrenia, MDD, Bipolar) Latinos Blacks Whites 50 45 40 35 30 25 20 15 10 5 0 Minsky S, Vega W, Miskimen T, Gara M, Escobar JI, Arch Gen Psychiatry, 60:637-644, 2003 Percent Diagnosed as Schizophrenia (N=19,219) Latinos (N=1531) Blacks (N= 6,475) Whites (N=10,339 14 12 10 8 6 4 2 0 Minsky S, Vega W, Miskimen T, Gara M, Escobar JI, Arch Gen Psychiatry, 60:637-644, 2003 IMMIGRATION: ADVANTAGE OR DISDVANTAGE? Immigration About 50% of Latinos in the US are Immigrants Hispanics born or living in the US appear to be at a greater risk for mental disorders than counterparts born or living in their native countries Stress of trying to integrate into US society, feelings of alienation and discrimination may increases risk for some disorders Longer time of residence in US and younger age at entry increase risk for immigrants Protective effects of strong cultural and familial ties may weaken when living in the US Longer residence in US and younger age at immigration increase risk (vulnerable period?) Vega WA, et al. 1998; Alderete E, et al. 2000 Epidemiological Studies in USA Ethnic Groups Study Immigrants/ USA Language Advantages Immigrants? White vs Black vs. Hispanics NCSR 299/5124 English YES Non-Hispanic Whites NESARC 1541/23,622 English/Spanish YES Mexican Origin ECA NCS MAPSS NESARC 706/538 English/Spanish YES 319/58 English YES 1810/1202 English/Spanish YES 227/2331 English/Spanish NCS NESARC 54/16 434/563 English NLAAS 1630/924 English/Spanish Puerto Rican Hispanics English/Spanish YES NO NO NO? 12 Month Prevalence of Mood and Addictive Disorders in Males (Vega et al, 1997) 10 Drugs Alcohol Mania 5 Dysthymia 0 Depression USA MEXICO 12-month Substance Abuse/Dependence Rate by Nativity, Age at Time of Entry into US, and Present Age Age 0–16 at Entry US Age 25+ at Entry US Age 17–24 at Entry US US born 20 15 % 10 5 0 10 20 30 40 50 60 Age (years) • U.S. born significantly different (p < 0.001) from each immigrant group (controlling for sex and present age). • Immigrants Age 0–16 at Entry US vs Age 17–24 at Entry US significantly different (p = 0.02) for present age 18–24. Vega WA, et al. In press Prevalence of Current Diagnoses in Immigrants and Native Born in Spain (N=1500 each)* P<.0001 *Garcia-Campayo et al, 2011 Unhealthy Habits in Pregnant Women Positive for Drugs Positive for Alcohol 45 40 35 30 25 20 15 10 5 0 Latin White, Women US-born Modified from Vega et al, 1993 Smokers 10 Year Age-Education Adjusted Coronary Heart Disease Mortality Risk for Mexican-American Adults US-born Spanish US-born English Mexico-born 30.00% 25.00% 20.00% 15.00% 10.00% 5.00% 0.00% MALES FEMALES Sundquist & Winkleby Am J Public Health, 89:723-730, 1999 Cultural Gradient and Blood Pressure Average Systolic Blood Pressure 125 Whites Latin Immigrants 120 115 110 105 100 95 Low Middle Socioeconomic Status Steffen PR, Journal of Behavioral Medicine, 29: 501-510, 2006 High Cardiovascular Paradox in New Jersey (Moreyra et al, presented at GHEC, Cuernavaca, Mexico, Abril 2010) Table 1. Clinical Characteristics NJ 1994-2007 Hospitalized AMI Hispanic n=13,106 Whites n=190,142 n (%) 6.5% 93.6% Age, y 67 + 15* 71 + 14 Hypertension, n (%) 69.7%* 63.7% Diabetes Mellitus, n (%) 39.2%* 29.1% Renal Disease, n (%) 11.3%* 11.5% • Hispanics were younger (67 years vs. 71 years), • more likely to have – hypertension (70% vs. 64%), – and diabetes (39% vs. 29%), • all differences significant, p<0.0001. Table 2. Multivariable Adjusted Associations (Interventions) NJ 1994-2007 Hospitalized AMI PCI, n (%) CABG, n (%) • • Hispanic n=13,106 Whites n=190,142 Adjusted OR/HR (95% CI) Adjuste d p value 21.21% 18.49% 0.94 (0.900.99) 0.03 8.42% 8.81% 0.98 (0.911.07) 0.72 Hispanics had lower adjusted rates of percutaneous interventions: – (PCI) (OR 0.94, CI 0.90-0.99, p=0.03), but similar rates of revascularization: – by CABG (OR 098, CI 0.91-1.07, p=0.72. Table 2. Multivariable Adjusted Associations (Mortality) NJ 1994-2007 Hospitalized AMI Hispanic n=13,106 Whites n=190,142 Adjusted OR/HR (95% CI) Adjuste d p value 12% 14.7% 0.88 (0.830.93) <0.000 1 30 Day Death 13.6% 17.1% 0.95 (0.900.99) 0.047 1 Year Death 22.8% 27.6% 0.98 (0.941.01) 0.23 In-Hospital Death • Hispanics had lower: • In-hospital (HR 0.88, CI 0.83-0.93, p<0.001) and • 30-day mortality (HR 0.95, CI 0.90-0.99, p=0.047), • But at one year the survival difference was no longer significant (HR 0.98, CI 0.94-1.01, p=0.23). Summary of Results Despite higher prevalence of risk factors and lower rates of PCI in Hispanics, the in-hospital and 30day post AMI mortality is lower, but the difference fades at 1-year. The Latino Paradox: Mortality (Hazard Ratios) Latinos vs. Non Latino Whites in the US (NLMS Data) 1 0.8 0.6 0.4 0.2 0 Males Mexican Central/South Amer. Abraido-Lanza et al AJPH 1999 Females Puerto Rican Non-Latino Whites Cuban Potential Explanations for Mental Health “Advantages” of Immigrants in the US Measurement Error? “Salmon” Effect misinterpretation of questions; language & translation issues; Selective Migration cross-cultural equivalence Healthier Habits Kin networks and Family Response Bias? social desirability, social approval, acquiescence Support? Advantages of Bilingualism o Bilingual people (French/English) obtain better results in execution tests, have better cognitive flexibility, better ability to negotiate abstract concepts than monolingual people1 o Similar results have been observed in the case of Hispanic origin people in the United States 2,3 1-Peal and Lambert, 1962 2-Rumbaut and Ima 1988 3-Portes 1997) Immigration and Psychosis: The Experience in England o o o o 1960’s: “High prevalence of Schizophrenia in Caribbean Immigrants to the UK” (1) 1980’s: “Schizophrenia is 14 times higher among Caribbean immigrants than in the general UK population (2) and this also applies to the second generation born in England (3) 1990’s: Studies with more methodological sophistication also showed an excess of schizophrenia (4) and mania (5) among Caribbean immigrants. However, other studies showed slight or no differences (6) 2000’s; The AESOP study calls immigration “a risk factor for psychosis (7) 1-Sharpley et al, 2001; 2- Harrison et al, 1988; 3-Harrison et al, 1997; 4-Wessely et al, 1991 5- Van Os et al, 1996; 6-Bughra et al 1997; 7- AESOPStudy Group 2002 Social Aspects of the Caribbean Migration to the United Kingdom o o o Disadvantages and travails of Black people and ethnic minorities in England. Afro-Caribbeans are more likely to be arrested or be transported by the police, to be admitted to psychiatric services against their will and to be locked or confined. “Diagnoses of psychosis made by White psychiatrists on Afro-Caribbeans are based on the notion that the person is strange, undesirable, bizarre, aggressive and dangerous” Raleigh and Almond 1995; Fernando 1998; Hickling FW, Robertson-Hickling H, Hutchinson G, Migration and Mental Health, in Hickling FW, Sorel E (eds), Images of Psychiatry: The Caribbean, Stephenson Litho Press, Jamaica, 2005 (pages 153-177 Comments on Studies Associating Psychosis with Migration o o o o o There is ethnic variation in the presentation of psychotic symptoms 1 Documented bias in the diagnosis pf certain ethnic groups (African Americans in USA) 2 The diagnosis of Afro-Caribbeans in England is possibly due to a similar bias. Studies of Afro-Caribbeans in Jamaica do not show an excess of psychotic disorders. 3 The results of the old north American studies and the more recent European studies relating migration and psychosis may be due to these biases. 1-Vega WA, Lewis-Fernandez R, Current Psychiatric Reports, 2008, 10:223-228 2-Minsky S, Vega W, Miskimen T et al, Arch Gen Psychiatry, 2003, 60:637-644 3-Hickling FW, Sorel E (eds), Images of Psychiatry: The Caribbean, Stephenson Litho Press, Jamaica, 2005 Reflexions on Immigration and Psychopathology o o o o o o o Immigration is a risk factor with a high level of variability. It is related to motivations for migrating, social conditions, language, culture, acceptance of the immigrant in the new environment, employment, etc. Unfortunately, color of the skin continues to play a significant role (racism). Language is a critical factor Resilience, personality, social support, are protective factors. Immigration may have an impact on certain psychiatric disorders but not in others. Epidemiological vs. Clinical Studies.