February 2006 Vol.316, No. 2
PERSPECTIVES IN PHARMACOLOGY
Striatal a6* Nicotinic Acetylcholine Receptors: Potential
Targets for Parkinson's Disease Therapy
Maryka Quik and J. Michael Mclntosh 481
ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Nucleoside Ester Prodrug Substrate Specificity of Liver
Carboxylesterase
Christopher P. Landowski, Philip L. Lorenzi, 572
Xueqin Song, and Gordon L. Amidon
In Vivo Evaluation of P-glycoprotein Function at the Blood-
Brain Barrier in Nonhuman Primates Using [ T1 C]Verapamil
Young-Joo Lee, Jun Maeda, 647
Hiroyuki Kusuhara, Takashi Okauchi,
Motoki Inaji, Yuji Nagai, Shigeru Obayashi,
Ryuji Nakao, Kazuloshi Suzuki, Yuichi
Sugiyama, and Tetsuya Suhara
Yvonne Y. Lau, Hideaki Okochi,
Yong Huang, and Leslie Z. Benet
762 Multiple Transporters Affect the Disposition of Atorvastatin and Its Two Active Hydroxy Metabolites: Application of in
Vitro and ex Situ Systems
Repression of Cytochrome P450 Activity in Human
Hepatocytes in Vitro by a Novel Hepatotrophic Factor,
Augmenter of Liver Regeneration
The Lymph Lipid Precursor Pool Is a Key Determinant of
Intestinal Lymphatic Drug Transport
Wolfgang E. Thasler, Rania Dayoub,
Marcus Muhlbauer, Claus Hellerbrand,
Thomas Singer, Anja Grabe,
Thomas S. Weiss
Karl-Walter Jauch, Hans-Jiirgen Schlitt, and
822
881 Natalie L. Trevaskis,
Christopher J. H. Porter, and
William N. Charman
BEHAVIORAL PHARMACOLOGY
Differential in Vivo Potencies of Naltrexone and 6/3-NaltrexoI in the Monkey
772
Analysis of the Antinociceptive Effect of the Flavonoid
Myricitrin: Evidence for a Role of the L-Arginine-Nitric Oxide and Protein Kinase C Pathways
High-Efficacy 5-Hydroxytryptamine 1A Receptor Activation
Counteracts Opioid Hyperallodynia and Affective
Conditioning
Differential Gender-Related Vulnerability to Depression
Induction and Converging Antidepressant Responses in Rats
M. C. Holden Ko, Mary F. Divin,
Heeseung Lee, James H. Woods, and
John R. Traynor
Flavia Carla Meotti, Ana Paula Luiz,
Moacir Geraldo Pizzolatti,
Candida A. L. Kassuya, Joao B. Calixto, and
Adair R. S. Santos
Francis C. Colpaert, Kristof Deseure,
Luis Stinus, and Hugo Adriaensen
Miao-Kun Sun and Daniel L. Alkon
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CARDIOVASCULAR
Neuronal Nitric-Oxide Synthase Inhibition Facilitates
Adrenergic Neurotransmission in Rat Mesenteric Resistance
Arteries
[s] QT Prolongation Modifies Dynamic Restitution and Hysteresis of the Beat-to-Beat QT-TQ Interval Relationship during
Normal Sinus Rhythm under Varying States of Repolarization
MRS2500 L2-Iodo-M > -methyl-(,V)-methanocarba-2'deoxyadenosine-3',5'-bispliosphate], a Potent, Selective, and
Stable Antagonist of the Platelet PlYy Receptor with Strong
Antithrombotic Activity in Mice
Effects of Phytoestrogens on Sarcoplasmic/Endoplasmic
Reticulum Calcium ATPase 2a and Ca 2+ Uptake into Cardiac
Sareoplasmic Reticulum
Differential Effects of the Phosphodiesterase Type 5 Inhibitors
Sildenafil, Vardenafil, and Tadalafil in Rat Aorta
Role of Hydrogen Sulfide in the Cardioprotection Caused by
Ischemic Preconditioning in the Rat Heart and Cardiac
Myocytes
Tachycardia Caused by A
2A
Adenosine Receptor Agonists Is
Mediated by Direct Sympathoexcitation in Awake Rats
Sphingosine 1-Phosphate Induces Endothelial Nitric-Oxide
Synthase Activation through Phosphorylation in Human
Corpus Cavernosum
An Increase in Late Sodium Current Potentiates the
Proarrhythmic Activities of Low-Risk QT-Prolonging Drugs in
Female Rabbit Hearts
In Vivo Cardiac Electrophysiologic Effects of a Novel
Diphenylphosphine Oxide I
Kur
Blockcr, (2-Isopropyl-5methylcyclohexyl) Diphenylphosphine Oxide, in Rat and
Nonhuman Primate
Attenuation of Vascular Smooth Muscle Cell Proliferation by l-
Cyclohexyl-3-dodecyl Urea Is Independent of Soluble Epoxidc
Hydrolase Inhibition
Mesenteric Vasoconstriction and Hindquarters Vasodilatation
Accompany the Pressor Actions of Exendin-4 in Conscious
Rats
CELLULAR AND MOLECULAR
Mapping the Binding Site of Six Nonpeptide Antagonists to the
Human V
2
-Renal Vasopressin Receptor
Dominant Role for Calpain in Thromboxane-Induced
Neuromicrovascular Endothelial Cytotoxicity
Antimelanoma Activity of Apoptogenic Carbonyl Scavengers
Oxymetazoline Inhibits Proinflammatory Reactions: Effect on
Arachidonic Acid-Derived Metabolites
Direct Block of Human Ether-a-go-go -Related Gene Potassium
Channels by Caffeine
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
DNA Repair Enzyme, O rt -Methylguanine DNA
Methyltransferase, Modulates Cytotoxicity of Camptothccin-
Derived Topoisomerase I Inhibitors
Yukako Hatanaka, Nariimi Hobara,
Jin Honghua, Shinji Akiyama, Hideki Nawa,
Yuta Kobayashi, Fusako Takayama, Yutaka
Gomita, and Hiromu Kawasaki
Anthony A. Fossa, Todd Wisialowski, and
Kimberly Crimin
Beatrice Hechler, Christelle Nonnc.
Eun Joo Roh, Marco Catlaneo, Jean-Pierre
Cazenave, Francois Lanza, Kenneth A.
Jacobson. and Christian Gachet
Marnie L. Olson, Margaret E. Kargacin,
Thomas W. Honeyman,
Christopher A. Ward, and Gary J. Kargacin
Clebcr E. Teixcira, Fernanda B. M. Priviero, and R. Clinton Webb
Jin-Song Bian, Qian Chen Yong,
Ting-Ting Pan, Zhan-Ning Feng,
Muhammed Yusuf Ali, Shufeng Zhou, and
Philip Keith Moore
Arvinder K. Dhalla, Mei-Yee Wong,
Wei-Qun Wang, Italo Biaggioni, and
Luiz Belardinelli
Roberta d'Emmanuele di Villa Bianca,
Raffaella Sorrentino, Rosalinda Sorrentino,
Ciro Imbimbo, Alessandro Pahnieri,
Ferdinando Fusco, Mario Maggi,
Raffaele De Palma, Giuseppe Cirino, and
Vincenzo Mirone
Lin Wu, John C. Shryock, Yejia Song, and
Luiz, Belardinelli
Christopher P. Regan, Audrey A. Wallace,
Hillary K. Cresswell, Charity L. Atkins, and
Joseph J. Lynch, Jr.
Benjamin B. Davis, Christophe Morisseau,
John W. Newman, Theresa L. Pederscn,
Bruce D. Hammock, and Robert H. Weiss
Sheila M. Gardiner, Julie E. March,
Philip A. Kemp, and Terence Bennett
Rosemarie Macian-Dazard,
Nicholas Callahan, Zhen Xu, Nan Wu, Marc
Thibonnier, and Menachcm Shonam
Chrisliane Quiniou, Florian Sennlaub,
Martin H. Beauchamp, Daniella Checchin,
Isabelle Lahaic, Sonia Brault,
Fernand Gobeil, Jr., Mirna Sirinyan,
Amna Kooli, Pierre Hardy,
Alexey Pshezhetsky, and Sylvain Chemtob
Georg T. Wondrak, Myron K. Jacobson, and
Elaine L. Jacobson
Ingrid Beck-Speier, Niru Dayal, Erwin Karg,
Konrad L. Maier, Gabrielc Schumann,
Manuela Semmler, and Stephan M. Koelsch
S. L. Cockeriil and J. S. Mitcheson
Ching-Chuan Kuo, Jin-Fen Liu, and
Jang-Yang Chang
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ENDOCRINE AND DIABETES
Blood Glucose-Lowering Nuclear Receptor Agonists Only
Partially Normalize Hepatic Gene Expression in db/db Mice
Michael Loffler, Martin Bilban,
Mark Reimers, Werner Waldhausl, and
Thomas M. Slulnig
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
Adenosine Al Receptor Antagonist Blunts Urinary Potassium
Excretion, but Not Renal Hemodynamic Effects, Induced by
Carbonic Anhydrase Inhibitor in Rats
Roles of Cyclooxygenase-2 and Prostacyclin/IP Receptors in
Mucosal Defense against Ischemia/Reperfusion Injury in
Mouse Stomach
Critical Role of Plasminogen Activator Inhibitor-1 in
Cholestatic Liver Injury and Fibrosis
Genetic Variants of the Human Dipeptide Transporter PEPT1
Xiaosun Zhou and Curtis K. Kost, Jr.
Tohru Kotani, Atsushi Kobata,
Eiji Nakamura, Kikuko Amagase, and
Koji Takeuchi
Ina Bergheim, Luping Guo,
Molly Anne Davis, Ilinca Duveau, and
Gavin E. Arteel
Paseale Anderle, Carsten Uhd Nielsen, Julia
Pinsonneault, Pernille Lindskov Krog,
Birger Brodin, and Wolfgang Sad6e
Rong-Jyh Lin, Bin-Nan Wu, Yi-Ching Lo,
Li-Mei An, Zen-Kong Dai, Young-Tso Lin,
Chao-Shun Tang, and Ing-Jun Chen
A Xanthine-Based Epithelium-Dependent Airway Relaxant
KMUP-3 {7-[2-[4-(4-Nitrobenzene)piperazinyl]ethyl]-l,3dimethylxanthine) Increases Respiratory Performance and
Protects against Tumor Necrosis Factor-a-Induced Tracheal .
Contraction, Involving Nitric Oxide Release and Expression of cGMP and Protein Kinase G
Sex Differences in the mRNA, Protein, and Functional
Expression of Organic Anion Transporter (Oat) 1, Oat3, and
Organic Cation Transporter (Oct) 2 in Rabbit Renal Proximal
Tubules
The Relaxant Activity of 4,7-Dimethyl-l,2,5-oxadiazolo[3,4-
(flpyridazine 1,5,6-Trioxide in the Mouse Corpus Cavernosum
M
2
and M
3
Muscarinic Receptor Activation of Urinary
Bladder Contractile Signal Transduction. I. Normal Rat
Bladder
M
2
and M
3
Muscarinic Receptor Activation of Urinary
Bladder Contractile Signal Transduction. II. Denervated Rat
Bladder
Selective Inhibition of Phosphodiesterase-4 Ameliorates
Chronic Colitis and Prevents Intestinal Fibrosis
Carlotta E. Groves, Wendy B. Suhre,
Nathan J. Cherrington, and Stephen H.
Wright
Cemil Gormen, H. Sinem Buyiiknacar,
Alexander Ya Kots, Fend Murad, Olcay
Kiroglu, and Eda Karabal Kumcu
Alan S. Braverman, Amit S. Tibb, and
Michael R. Ruggieri, Sr.
Alan S. Braverman, Leo R. Doumanian. and
Michael R. Ruggieri, Sr.
S. Videla, J. Vilaseca, C. Medina,
M. Mourelle, F. Guarner, A. Salas, and
J.-R. Malagelada
INFLAMMATION AND IMMUNOPHARMACOLOGY
Inhibition of Leukocyte Elastase, Polymorphonuclear
Chemoinvasion, and Inflammation-Triggered Pulmonary
Fibrosis by a 4-Alkyliden-/j{-Iactam with a Galloyl Moiety
Periplocoside E, an Effective Compound from Periploca
sepium Bge, Inhibited T Cell Activation in Vitro and in Vivo
A Novel Cannabinoid Peripheral Cannabinoid Receptor-
Selective Inverse Agonist Blocks Leukocyte Recruitment in
Vivo
Isabella Dell'Aica, Luigi Sartor, Paola
Galletti, Daria Giacomini, Arianna
Quintavalla, Fiorella Calabrese, Cinzia
Giacometti. Enrico Brunetta, Francesco
Piazza, Carlo Agostini, and Spiridione
Garbisa
Yi-Na Zhu, Wei-Min Zhao, Yi-Fu Yang,
Qun-Fang Liu, Yu Zhou, Jia Tian, Jia Ni,
Yun-Feng Fu, Xiang-Gcn Zhong. Wei Tang,
Ru Zhou, Pti-Lan He, Xiao-Yu Li, and
Jian-Ping Zuo
Charles A. Lunn, Jay S. Fine,
Alberto Rojas-Triana, James V. Jackson,
Xuedong Fan, Ted T. Kung,
Waldemar Gonsiorek, Martin A. Schwarz,
Brian Lavey, Joseph A. Kozlowski,
Satwant K. Narula, Daniel J. Lundell,
R. William Hipkin, and Loretta A. Bober
Nahid A. Shahabi, Kathy McAllen, and
Bnrt M. Sharp
5 Opioid Receptors Stimulate Akt-Dependent Phosphorylation of c-jun in T Cells
NEUROPHARMACOLOGY
5-Hydroxytryptamine 1A Receptor Blockade Facilitates
Aversive Learning in Mice: Interactions with Cholinergic and
Glutamatergic Mechanisms
Nather Madjid, Elin Elvander Tottie, Maria
LuLlgen, Bjorn Meister, Johan Sandin,
Alexander Kuzmin, Oliver Stiedl, and Sven
Ove Ogren
797
539
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780
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592
636
709
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753
869
875
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Different Effects of Opioid and Cannabinoid Receptor
Agonists on C-Fiber-Induced Extracellular Signal-Regulated
Kinase Activation in Dorsal Horn Neurons in Normal and
Spinal Nerve-Ligated Rats
Effects of Exogenous and Endogenous Cannabinoids on
GABAergic Neurotransmission between the Caudate-Putamen and the Globus Pallidus in the Mouse
Comparison of Galantamine and Donepezil for Effects on
Nerve Growth Factor, Cholinergic Markers, and Memory
Performance in Aged Rats
Presynaptic a x
Adrenergic Receptors Differentially Regulate
Synaptic Glutamate and GABA Release to Hypothalamic
Presympathetic Neurons
D2-Like Receptors Mediate the Expulsion Phase of
Ejaculation Elicited by 8-Hydroxy-2-(di-JVpropylamino)tetralin in Rats
Apolipoprotein E-Derived Peptides Block «7 Neuronal
Nicotinic Acetylcholine Receptors Expressed in Xenopus
Oocytes
Characterization of Opioid-Binding Sites in Zebrafish Brain
Improved Bioavailability of the mGlu2/3 Receptor Agonist
LY354740 Using a Prodrug Strategy: In Vivo Pharmacology of
LY544344
Iptakalim as a Human Nicotinic Acetylcholine Receptor
Antagonist
Novel Compounds That Interact with Both Leukotriene B
4
Receptors and Vanilloid TRPV1 Receptors
Yasuhiko Kawasaki, Tatsuro Kohno, and
Ru-Rong Ji
Birgit Engler, Ilka Freiman,
Michal Urbanski, and Bela Szabo
C. M. Hernandez, D. A. Gearhart, V. Parikh,
E. J. Hohnadel, L. W. Davis,
M. L. Middlemore, S. P. Warsi, J. L. Waller, and A. V. Terry, Jr.
Qian Chen, De-Pei Li, and Hui-Lin Pan
Pierre Clement, Jacques Bernabe,
Hosein Kami Kia, Laurent Alexandre, and
Francois Giuliano
Elaine A. Gay, Rebecca C. Klein, and
Jerrel L. Yakel
Veronica Gonzalez-Nunez,
Alejandro Barrallo, John R. Traynor, and
Raquel E. Rodriguez
Linda M. Rorick-Kehn, Everett J. Perkins,
Karen M. Knitowski, John C. Hart,
Bryan G. Johnson, Darryle D. Schoepp, and
David L. McKinzie
Jim Hu, Kari Lindenberger, Gang Hu,
Hai Wang, Ronald J. Lukas, and Jie Wu
Douglas McHugh, R. Shannon McMaster,
Roger G. Pertwee, Sucharita Roy, Anu
Mahadevan, Raj K. Razdan, and Ruth
A. Ross
TOXICOLOGY
Protective Effect of Type 2 Diabetes on Acetaminophen-
Induced Hepatotoxicity in Male Swiss-Webster Mice
Pulmonary Bronchiolar Cytotoxicity and Formation of
Dichloroacetyl Lysine Protein Adducts in Mice Treated with
Trichloroethylene
LETTERS TO THE EDITOR
Comments on "Shift from Biliary to Urinary Elimination of
Acetaminophen-Glucuronide in Acetaminophen-Pretreated
Rats"
Sharmilee P. Sawant, Ankur V. Dnyanmote,
Mayurranjan S. Mitra, Jaya Chilakapati,
Alan Warbritton, John R. Latendresse, and
Harihara M. Mehendale
Poh-Gek Forkert, Brandie Millen,
Lawrence H. Lash, David A. Putt, and
Burhan I. Ghanayem
K. Allegaert and D. Tibboel
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