MOLECULAR
PHARMACOLOGY
May 2002
Volume 61
Number 5
http://molpharm.aspetjournals.org
ISSN 0026-895X
MINIREVIEW
Erratum This article appeared in the previous issue but was not correctly identified as a minireview.
Novel "Nonkinase" Phorbol Ester Receptors: The C-l Domain Connection Marcelo G. Kazanietz 61:
759-767
1265
ACCELERATED COMMUNICATION
G Protein-Coupled Receptors as Direct Targets of Inhaled Anesthetics
Yumiko Ishizawa, Ravindernath Pidikiti, Paul A. Liebman, and Roderic G. Eckenhoff
945
ARTICLES
Parthenon"de, an Inhibitor of the Nuclear Factor-KB Pathway, Ameliorates Cardiovascular
Derangement and Outcome in Endotoxic Shock in Rodents Maeve Sheehan, Hector R.
Wong, Paul W. Hake, Vivek Mal%otra, Michael O'Connor, and
Basilia Zingarelli
953
*
j
Three-Dimensional Quantitative Structure-Activity Relationships of Inhibitors of P-Glycoprotein
Sean Ekins, Richard B. Kim, Brenda F. Leake, Anne H. Dantzig, Erin G. Schuetz, Lu-Bin Lan,
Kazuto Yasuda, Robert L. Shepard, Mark A. Winter, John D. Schuetz, James H, Wikel, and
Steven A. Wrighton
964
Application of Three-Dimensional Quantitative Structure-Activity Relationships of P-Glycoprotein
Inhibitors and Substrates
Sean Ekins, Richard B. Kim, Brenda F. Leake, Anne H. Dantzig, Erin G. Schuetz, Lu-Bin Lan,
Kazuto Yasuda, Robert L. Shepard, Mark a Winter, John D. Schuetz, James H. Wikel, and
Steven A. Wrighton
974
Expression and Functional Characterization of Rat Organic Anipn Transporter 3 (rOat3) in the
Choroid Plexus
Yoshinori Nagata, Hiroyuki Kusuhara, Hitoshiu Endou, and'Yuichi Sugiyama
982
c{>apMaKonon4H!/iw I
M03
1-Acetylcarnitine Induces Analgesia by Selectively Up-Regulating mGlu2 Metabotropic Glutamate
Receptors
S. Chiechio, A. Caricasole, E. Barletta, M. Storto, M. V. Catania, A. Copani, M. Ve rtechy,
R. Nicolai, M. Calvani, D. Melchiorri, and F, Nicoletti
989
The Cyclopentenone Prostaglandin 15-Deoxy- A1214-Prostaglandin J 2 Attenuates the Development of
Acute and Chronic Inflammation
Salvatore Cuzzocrea, Nicole S. Wayman, Emanuela Mazzon, Laura Dugo, Rosanna Di Paola,
Ivana Serraino, Domenico Britti, Prabal K. Chatterjee, Achille P. Caputi, and
Christoph Thiemermann
997
Differences in the Cellular Localization and Agonist-Mediated Internalization Properties of the a±Adrenoceptor Subtypes
Dan Chalothorn, Dan F. McCune, Stephanie E. Edelmann, Mary L. Garcia-Cazarin,
Gozoh Tsujimoto, and Michael T. Piascik
1008
Antidepressant Treatments Induce the Expression of Basic Fibroblast Growth Factor in Cortical and
Hippocampal Neurons
Alessandra Mallei, Bitao Shi, and Italo Mocchetti
1017
Mutagenesis and Modelling of the a lb -Adrenergic Receptor Highlight the Role of the Helix 3/Helix 6
Interface in Receptor Activation
Peter J, Greasley, Francesca Fanelli, Olivier Rossier, Liliane Abuin, and Susanna Cotecch ia
1025
Reduced Phosphodiesterase 3 Activity and Phosphodiesterase 3A Level in Synthetic Vascular Smooth
Muscle Cells: Implications for Use of Phosphodiesterase 3 Inhibitors in Cardiovascular Tissues
Heather A. Dunkerley, Douglas G. Tilley, Daniel Palmer, Hanguan Liu, Sandra L. Jimmo, and
Donald H. Maurice
1033
Refinement of the Conformation of a Critical Region of Charge-Charge Interaction between
Cholecystokinin and Its Receptor
Xi-Qin Ding, Delia I. Pinon, Kristina E. Furse, Terry P. Lybrand, and Laurence J. Miller
1041
2-Methoxyestradiol and Analogs as Novel Antiproliferative Agents: Analysis of Three -Dimensional
Quantitative Structure-Activity Relationships for DNA Synthesis Inhibition and Estrogen Receptor
Binding
Richard A. Hughes, Trudi Harris, Emile Altmann, David McAllister, Ross Vlahos, Alan Robertson,
Mark Cushman, Zhiqiang Wang, and Alastair G. Stewart
1053
Importance of the y-Aminobutyric Acid B Receptor C-Termini for G-Protein Coupling
Sylvia Grilnewald, Bettina J. Schupp, Stephen R. Ikeda, Rohini Kuner, Frank Steigerwald,
Hans-Christian Kornau, and Georg Kohr
1070
Functional and Analytical Evidence for Scavenging of Oxygen Radicals by L-Arginine
Achim Lass, Astrid Suessenbacher, Gerald Wolkart, Bernd Mayer, and Friedrich Brunner
1081
Post-Transcriptional Regulation of Hepatic NADPH-Cytochrome P450 Reductase by Thyroid Hormone;
Independent Effects on Poly(A) Tail Length and mRNA Stability
Dongxu Liu and David J. Waxman
1089
Up-Regulation of Glutamate Receptors in Nucleus Tractus Solitarii Underlies Potentiation of
Baroreceptor Reflex by Heat Shock Protein 70
Samuel H. H. Chan, Kui-Fen Chang, Chen-Chun Ou, and Julie Y. H. Chan
1097
Ethylbromide Tamoxifen, a Membrane-Impermeant Antiestrogen, Activates Smooth Muscle CalciumActivated Large-Conductance Potassium Channels from the Extracellular Side
Gregory M. Dick, A. Christy Hunter, and Kenton M. Sanders
1105
Metabotropic Glutamate Receptor 1 Internalization Induced by Muscarinic Acetylcholine Receptor
Activation: Differential Dependency of Internalization of Splice Variants on Nonvisual Arrestins
Stuart J. Mundell, Anne-Lise Matharu, Giordano Pula, David Holman, Peter J. Roberts, and
Eamonn Kelly
1114
Methamphetamine Causes Coordinate Regulation of Src, Cas, Crk, and the Jun N -Terminal KinaseJun Pathway
Subramaniam Jayanthi, Michael T. McCoy, Bruce Ladenheim, and Jean hud Cadet
1124
Five Amino Acids of the Xenopus laevis Corticotropin-Releasing Factor Type 2 Receptor Mediate Differential
Binding of CRF Ligands in Comparison with Its Human Counterpart Frank M. Dautzenberg, Jacqueline
Higelin, Olaf Brauns, Brigitte Butscha, and Richard L. Hauger 1132
Lack of Susceptibility of Bicyclic Nucleoside Analogs, Highly Potent Inhibitors of Varicella -Zoster
Virus, to the Catabolic Action of Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase
Jan Balzarini, Rebecca Sienaert, Sandra Liekens, Andre Van Kuilenburg, Antonella Carangio,
Robert Esnouf, Erik De Clercq, and Chris McGuigan
1140
Native CYP2C11: Heterologous Expression in Saccharomyces cerevisiae Reveals a Role for Vacuolar
Proteases Rather Than the Proteasome System in the Degradation of This Endoplasmic Reticulum
Protein
Bernard P. Murray, Victor G. Zgoda, and Maria Almira Correia
1146
A G-Quadruplex-Interactive Potent Small-Molecule Inhibitor of Telomerase Exhibiting in Vitro and in
Vivo Antitumor Activity
Sharon M. Gowan, John R. Harrison, Lisa Patterson, Melanie Valenti, Martin A. Read,
Stephen Neidle, and Lloyd R. Kelland
1154
Regulation of Fibronectin Fibrillogenesis by Protein Kinases in Cultured Rat Osteoblasts
Rong-Sen Yang, Chih-Hsin Tang, Qing-Dong Ling, Shing-Hwa Liu, and Wen-Mei Fu
1163
Identification of Albumin Precursor Protein, Phi AP3, and a-Smooth Muscle Actin as Novel
Components of Redox Sensing Machinery in Vascular Smooth Muscle Cells
M. T. Holderman, K. P. Miller, L. J. Dangott, and K, S. Ramos
1174
Substrate-Induced Up-Regulation of Aldose Reductase by Methylglyoxal, a Reactive Oxoaldehyde
Elevated in Diabetes
Ki Churl Chang, Kyung Shin Paek, Hyo Jung Kim, Young Soo Lee, Chihiro Yabe-Nishimura, and
Han Geuk Seo
1184
Critical Molecular Determinants of Voltage-Gated Sodium Channel Sensitivity to ^i-Conotoxins GIIIA/B
Theodore R. Cummins, Fabio Aglieco, and Sulayman D. Dib-Hajj
1192
The Critical Role of Transmembrane Prolines in Human Prostacyclin Receptor Activation
Jeremiah Stitham, Kathleen A. Martin, and John Hwa
1202
Enhanced Detection of Receptor Constitutive Activity in the Presence of Regulators of G Protein
Signaling: Applications to the Detection and Analysis of Inverse Agonists and Low-Efficacy Partial
Agonists
Philip J. Welsby, Elaine Kellett, Graeme Wilkinson, and Graeme Milligan
1211
The Nicotinic Allosteric Potentiating Ligand Galantamine Facilitates Synaptic Transmission in the
Mammalian Central Nervous System
Mdriton D. Santos, Manickavasagom Alkondon, Edna F. R. Pereira, Yasco Aracava,
Howard M. Eisenberg, Alfred Maelicke, and Edson X. Albuquerque
1222
Maleimide Is a Potent Inhibitor of Topoisomerase II in Vitro and in Vivo: A New Mode of Catalytic
Inhibition
Lars H. Jensen, Axelle Renodon-Corniere, Irene Wessel, Seppo W. Langer, Birgitte S0kilde,
Elisabeth V. Carstensen, Maxwell Sehested, and Peter B. Jensen
1235
Supersensitivity of Human Metabotropic Glutamate la Receptor Signaling in L929sA Cells
Hilde Lavreysen, Emmanuel Le Poul, Paul Van Gompel, Lieve Dillen, Josee E. Leysen, and
Anne S. J. Lesage
1244
Further Insight into Mechanism of Action of Clodronate: Inhibition of Mitochondrial ADP/ATP
Translocase by a Nonhydrolyzable, Adenine- Containing Metabolite
Petri P. Lehenkari, Maarit Kellinsalmi, Juha P. Ndpdnkangas, Kari V. Ylitalo, Jukka Monkkonen,
Michael J. Rogers, Alex Azhayeu, H. Kalervo Vaananen, and Ilmo E. Hassinen
1255
i
Correction to "Antitumor Activity of 2',3'-Dideoxycytidine Nucleotide Analog Against Tumors UpRegulating DNA Polymerase /3"
1263
Correction to "Caffeic Acid Phenethyl Ester and Curcumin: A Novel Class of Heme Oxygenase -1
Inducers"
1264