The Journal of
PHARMACOLOGY
And Experimental Therapeutics
A Publication of the American Society for Pharmacology and Experimental
Therapeutics
Vol. 321, No. 2
May 2007
Contents
PERSPECTIVES IN PHARMACOLOGY
Use of Wavelet and Fast Fourier Transforms in
Pharmacodynamics
Donald E. Mager and Darrell R. Abernethy
423
Jennifer L. Martelle, Renee Claytor,
Jason T. Ross, Beth A. Reboussin,
Amy Hauck Newman, and Michael A. Nader
573
Frank G. Boess, Jean De Vry, Christina Erb,
Timo Flessner, Martin Hendrix,
Joachim Luithle, Christoph Methfessel,
Bernd Riedl, Katrin Schnizler,
Franz-Josef van der Staay,
Marja van Kampen, Welf Burkhard Wiese,
and Gerhard Koenig
716
Ming-Hong Tai, Wen-Tsan Weng,
Wan-Chen Lo, Julie Y. H. Chan, CheJen Lin, Hing-Chung Lam, and ChingJiunn Tseng
455
Bradycardic Therapy Improves Left Ventricular Function and
Remodeling in Dogs with Coronary Embolization-Induced
Chronic Heart Failure
Yanping Cheng, Isaac George, Geng-Hua Yi,
Steven Reiken, Anguo Gu,
Yuankai Kenny Tao, Jordan Muraskin,
Siyi Qin, Kun-Lun He, Ilan Hay,
Kenward Yu, Mehmet C. Oz,
Daniel Burkhoff, Jeffrey Holmes, and
Jie Wang
469
Probucol [4,4'-[(l-Methylethylidene)bis(thio)]bis-[2,6-bis(l,ldimethylethyOphenol]] Inhibits Compensatory Remodeling
and Promotes Lumen Loss Associated with Atherosclerosis in
Apolipoprotein E-Deficient Mice
Ben J. Wu, Nick Di Girolamo,
Konstanze Beck, Colm G. Hanratty,
Katherine Choy, Jing Y. Hou, Michael
R. Ward, and Roland Stocker
477
The 5-Hydroxytryptamine2A Receptor Is Involved in (+)Norfenfluramine-Induced Arterial Contraction and Blood
Pressure Increase in Deoxycorticosterone Acetate-Salt
Hypertension
Wei Ni, Gregory D. Fink, and
Stephanie W. Watts
485
BEHAVIORAL PHARMACOLOGY
Effects of Two Novel D3-Selective Compounds, NGB 2904 [/V(4-(4-(2,3-Dichlorophenyl)piperazin-l-yl)butyl)-9/f-fluorene-2carboxamide] and CJ8 090 |7V-(4-(4-(2,3Dichlorophenyl)piperazin-l-yl)butyl)-4-(pyridin-2yl)benzamide], on the Reinforcing and Discriminative
Stimulus Effects of Cocaine in Rhesus Monkeys
The Novel a7 Nicotinic Acetylcholine Receptor Agonist N[(3«)-l-Azabicyclo[2.2.2]oct-3-yI]-7-[2-(methoxy)phenyl]-lbenzofuran-2-carboxamide Improves Working and
Recognition Memory in Rodents
CARDIOVASCULAR
\s\ Role of Nitric Oxide in a-Melanocyte-Stimulating HormoneInduced Hypotension in the Nucleus Tractus Soiitarii of the
Spontaneously Hypertensive Rats
Protective Role of Intracellular Zinc in Myocardial Ischemia/
Reperfusion Is Associated with Preservation of Protein Kinase
C Isoforms
Gulnura Karagulova, Yuankun Yue, Abel
Moreyra, Mohamed Boutjdir, and Irina
Korichneva
517
Functional Adenylyl Cyclase Inhibition in Murine
Cardiomyocytes by 2'(3')-O-(A'-Methylanthraniloyl)-Guanosine
5'-[Y-Thio]triphosphate
Dennis Rotllaender, Jan Matthes, Stephen
F. Vatner, Roland Seifert, and Stefan
Herzig
608
Epothilone B Inhibits Neointimal Formation after Rat Carotid
Injury through the Regulation of Cell Cycle-Related Proteins
Yong Lim, Tack-Joong Kim, Yong-Ri Jin,
Dong-Woon Kim, Jin-Sook Kwon, Ju-Hee
Son, Jae-Chul Jung, Mitchell A. Avery,
Dong Ju Son, Jin Tae Hong, and Yeo-Pyo
Yun
The in Vitro and in Vivo Cardiovascular Effects of A 9Tetrahydrocannabinol in Rats Made Hypertensive by Chronic
Inhibition of Nitric-Oxide Synthase
Saoirse E. O'Sullivan, Michael D. Randall,
and Sheila M. Gardiner
663
Characterization of the Relaxant Response to Ayv'-Dipropyl1,2-bis(2,6-dichloro-4-hy droxyphenyl)ethylenediamine in
Porcine Coronary Arteries
Alkje Moritz, Ronald Gust, and
Heinz H. Pertz
699
Open Channel Block of A-Type, KV4.3, and Delayed Rectifier
K+ Channels, KV1.3 and KV3.1, by Sibutramine
Sung Eun Kim, Hye Sook Ahn, Bok
Hee Choi, Hyun-Jong Jang, MyungJun Kim, Duck-Joo Rhie, Shin-Hee
Yoon, Yang-Hyeok Jo, Myung-Suk
Kim, Ki-Wug Sung, and Sang June
Hahn
753
Endocannabinoid Regulates Blood Pressure via Activation of
the Transient Receptor Potential Vanilloid Type 1 in Wistar
Rats Fed a High-Salt Diet
Youping Wang, Norbert E. Kaminski, and
Donna H. Wang
763
Danxin Wang, Xiaochun Sun, and
Wolfgang Sadee
544
Nina Roos, Nicolas Poulalbon, Dominique
Farge, Isabelle Madelaine, Alain Mauviel,
and Franck Verrecchia
583
Dorrah Deeb, Hao Jiang, Xiaohua Gao,
Shaza Al-Holou, Andrew L. Danyluk, Scott
A. Dulchavsky, and Subhash C. Gautam
616
CELLULAR AND MOLECULAR
Different Effects of Opioid Antagonists on jx-, 6-, and KOpioid Receptors with and without Agonist Pretreatment
In Vitro Evidence for a Direct Antifibrotic Role of the
Immunosuppressive Drug Mycophenolate Mofetil
H] Curcumin [l,7-Bis(4-hydroxy-3-methoxyphenyl)-l-6-heptadine3,5-dione; C2IH20O6] Sensitizes Human Prostate Cancer Cells to
Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand/
Apo2L-Induced Apoptosis by Suppressing Nuclear Factor-KB via
Inhibition of the Prosurvival Akt Signaling Pathway
Fluvastatin and Atorvastatin Affect Calcium Homeostasis of
Rat Skeletal Muscle Fibers in Vivo and in Vitro by Impairing
the Sarcoplasmic Reticulum/Mitochondria Ca 3+-Release System
ENDOCRINE AND DIABETES
Pioglitazone Induces Apoptosis in Human Vascular Smooth
Muscle Cells from Diabetic Patients Involving the
Transforming Growth Factor- 0/Activin Receptor-Like
Kinase-4/5/7/Smad2 Signaling Pathway
A Novel Glucagon Receptor Antagonist, NNC 25-0926, Blunts
Hepatic Glucose Production in the Conscious Dog
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
Cyclooxygenase (COX)-l and COX-2 Participate in 5,6Epoxyeicosatrienoic Acid-Induced Contraction of Rabbit
Intralobar Pulmonary Arteries
Antonella Liantonio, Viviana Giannuzzi,
Valentina Cippone, Giulia Maria Camerino,
Sabata Pierno, and Diana Conte Camerino
Emilio Ruiz, Santiago Redondo,
Antonio Gordillo-Moscoso, and
Teresa Tejerina
Noelia Rivera, Carrie A. Everett-Grueter,
Dale S. Edgerton, Tiffany Rodewald, Doss
W. Neat, Erica NJshimura, Marianne O.
Larsen, Lene O. Jacobsen, Kim Kristensen,
Christian L. Brand, and Alan D.
Cherrington
626
431
743
K. Trent Moreland, Jesse D. Procknow,
Randy S. Sprague, Jennifer L. Iverson,
Andrew J. Lonigro, and Alan H. Stephenson
446
RhoA Prenylation Inhibitor Produces Relaxation of Tonic
Smooth Muscle of Internal Anal Sphincter
Chirag A. Patel and Satish Rattan
501
Effects of a New Bioactive Lipid-Based Drug Carrier on
Cultured Hepatic Stellate Cells and Liver Fibrosis in Bile
Duct-Ligated Rats
Joanna E. Adrian, Klaas Poelstra, Gerrit L.
Scherphof, Dirk K. F. Meijer, Anne-miek
van Loenen-Weemaes, Catharina RekerSmit, Henriette W. M. Morselt, Peter
Zwiers, and Jan A. A. M. Kamps
536
Effect of (ff)-2-(2-Aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2phenylethyl)amino]ethyl} Acetanilide (YM178), a Novel
Selective /33-Adrenoeeptor Agonist, on Bladder Function
Toshiyuki Takasu, Masashi Ukai,
Shuichi Sato, Tetsuo Matsui, Itsuro Nagase,
Tatsuya Maruyama, Masao Sasamata, Keiji
Miyata, Hisashi Uchida, and Osamu
Yamaguchi
642
The Pancreatohepatorenal cAMP-Adenosine Mechanism
Edwin K. Jackson, Zaichuan Mi,
Lefteris C. Zacharia, Stevan P. Tofovic, and
Raghvendra K. Dubey
Edwin K. Jackson, Jin Ren,
Lefteris C. Zacharia, and Zaichuan Mi
799
Isabella Dell'Aica, Raffaele Niero,
Francesco Piazza, Anna Cabrelle,
Luigi Sartor, Cristiano Colalto,
Enrico Brunetta, Girieca Lorusso,
Roberto Benelli, Adriana Albini,
Fiorella Calabrese, Carlo Agostini, and
Spiridione Garbisa
492
(S> 1 -((S)-2-{ [1 - (4-Amino-3-chIoro-phenyl)-methanoy l]-amino}3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally
Available Selective Interleukin (IL)-Converting
Enzyme/Caspase-1 Inhibitor, Exhibits Potent AntiInflammatory Activities by Inhibiting the Release of IL-1/3 and
IL-18
Woods Wannamaker, Robert Davies,
Mark Namchuk, John Pollard, Pamella Ford,
George Ku, Caroline Decker, Paul Charifson,
Peter Weber, Ursula A. Germann, Keisuke
Kuida, and John C. R. Randle
509
Carbon Monoxide-Releasing Molecules Modulate LeukocyteEndothelial Interactions under Flow
Paula Urquhart, Guglielmo Rosignoli,
Dianne Cooper, Roberto Motterlini, and
Mauro Perretti
Yann Pellequer, Yvette Meissner,
Nathalie Ubrich, and Alf Lamprecht
656
Characterization of Renal Ecto-Phosphodiesterase
INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
Hyperforin Blocks Neutrophil Activation of Matrix
Metalloproteinase-9, Motility and Recruitment, and Restrains
Inflammation-Triggered Angiogenesis and Lung Fibrosis
Epithelial Heparin Delivery via Microspheres Mitigates
Experimental Colitis in Mice
Repression of Inflammatory Gene Expression in Human
Pulmonary Epithelial Cells by Small-Molecule IKB Kinase
Inhibitors
810
726
Robert Newton, Neil S. Holden,
Matthew C. Catley, Wale Oyelusi,
Richard Leigh, David Proud, and
Peter J. Barnes
734
Jun Yang, Hongtao Chen,
Iontcho R. Vlahov, Ji-Xin Cheng, and
Philip S. Low
462
Effect of CYP3A5 Expression on Vincristine Metabolism with
Human Liver Microsomes
Jennifer B. Dennison, David R. Jones,
Jamie L. Renbarger, and Stephen D. Hall
553
Anandamide Metabolism by Human Liver and Kidney
Microsomal Cytochrome P450 Enzymes to Form
Hydroxyeicosatetraenoic and Epoxyeicosatrienoic Acid
Ethanolamides
Natasha T. Snider, Andrei M. Kornilov,
Ute M. Kent, and Paul F. Hollenberg
590
Transport of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin
by Human Organic Anion Transporter 3, Organic Anion
Transporting Polypeptide 4C1, and Multidrug Resistance Pglycoprotein
Xiao-Yan Chu, Kelly Bleasby,
Jocelyn Yabut, Xiaoxin Cai,
Grace Hoyee Chan, Michael J. Hafey,
Shiyao Xu, Arthur J. Bergman,
Matthew P. Braun, Dennis C. Dean, and
Raymond Evers
673
Characterization of the Basal Promoter Element of Human
Organic Cation Transporter 2 Gene
Jun-ichi Asaka, Tomohiro Terada,
Ken Ogasawara, Toshiya Katsura, and
Ken-ichi Inui
684
Novel Nonviral Vectors Target Cellular Signaling Pathways:
Regulated Gene Expression and Reduced Toxicity
Feng Liu, Christine C. Conwell, Xing Yuan,
Lisa M. Shollenberger, and Leaf Huang
777
Enrique Sanchez-Pastor, Xochitl Trujillo,
Miguel Huerta, and Felipa Andrade
439
Effects of Pan- and Subtype-Selective JV-Methyl-D-aspartate
Receptor Antagonists on Cortical Spreading Depression in the
Rat: Therapeutic Potential for Migraine
Magali Peeters, Martin J. Gunthorpe,
Paul J. L. M. Strijbos, Paul Goldsmith,
Neil Upton, and Michael F. James
564
Pharmacokinetic-Pharmacodynamic Modeling of the
Respiratory Depressant Effect of Norbuprenorphine in Rats
Ashraf Yassen, Jingmin Kan, Erik Olofsen,
Ernst Suidgeest, Albert Dahan, and
Meindert Danhof
598
METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
\s\ Characterization of the pH of Folate Receptor-Containing
Endosomes and the Rate of Hydrolysis of Internalized AcidLabile Folate-Drug Conjugates
NEUROPHARMACOLOGY
Effects of Cannabinoids on Synaptic Transmission in the Frog
Neuromuscular Junction
Sex-/Ovarian Steroid-Dependent Release of Endomorphin 2
from Spinal Cord
Selective Blockade of 5-Hydroxytryptainine (5-HT)7 Receptors
Enhances 5-HT Transmission, Antidepressant-Like Behavior,
and Rapid Eye Movement Sleep Suppression Induced by
Citalopram in Rodents
Daya S. Gupta, Hans von Gizycki, and
Alan R. Gintzler
635
Pascal Bonaventure, Lisa Kelly,
Leah Aluisio, Jonathan Shelton, Brian Lord,
Ruggero Galici, Kirsten Miller, John Atack,
Timothy W. Lovenberg, and Christine
Dugovic
690
Differential Effects of the Tricyclic Antidepressant
Desipramine on the Density of Adrenergic Receptors in
Juvenile and Adult Rats
Nobiletin, a Citrus Flavonoid, Reverses Learning Impairment
Associated with iV-Methyl-o-aspartate Receptor Antagonism
by Activation of Extracellular Signal-Regulated Kinase
Signaling
Jean D. Deupree, Abbey L. Reed, and
David B, Bylund
770
Akira Nakajima, Tohru Yamakuni,
Kentaro Matsuzaki, Norihito Nakata,
Hiroshi Onozuka, Akihito Yokosuka,
Yutaka Sashida, Yoshihiro Mimaki, and
Yasushi Ohizumi
784
Antinociceptive Pharmacology of iV-(4-Chlorobenzyl)-iV'-(4hydroxy-3-iodo-5-methoxybenzyl) Thionrea, a High-Affinity
Competitive Antagonist of the Transient Receptor Potential
Vanilloid 1 Receptor
Lei Tang, Yan Chen, Zili Chen,
Peter M. Blumberg, Alan P. Kozikowski,
and Zaijie Jim Wang
791
Protective Effect of Glycyrrhizin on l-Methyl-4phenylpyridinium-Induced Mitochondrial Damage and Cell
Death in Differentiated PC12 Cells
Soo Bin Yim, Sang Eun Park, and
Chung Soo Lee
816
Isabelle Larosche, Philippe Letteron,
Bernard Fromenty, Nathalie Vadrot, Adje
Abbey-Toby, Gerard Feldmann, Dominique
Pessayre, and Abdellah Mansouri
526
Gilbert R. Kinsey, Jane McHowat,
Kennerly S. Patrick, and
Rick G. Schnellmann
707
TOXICOLOGY
HI Tamoxifen Inhibits Topoisomerases, Depletes Mitochondrial
DNA, and Triggers Steatosis in Mouse Liver
Role of Ca2+-Independent Phospholipase A2y in Ca2+Induced Mitochondrial Permeability Transition