The Journal of
PHARMACOLOGY
And Experimental Therapeutics
A Publication of the American Society for Pharmacology and Experimental Therapeutics
Vol. 322, No. 2
August 2007
Contents
PKRPSECTIVES IN PHARMACOLOGY
Evgeny Krynetskiy and Patrick McDonnell
427
Lawrence P. Carter, Roland R. Griffiths,
Patricia E. Suess, John H. Casada, Christopher
L. Wallace, and John D. Roache
749
Donna M. Platt, James K. Rowlett, and
Roger D. Spealman
894
MartaL. Capone, Stefania Tacconelli,
Maria G. Sciulli, Paola Anzellotti, Luigia Di
Francesco, Gabriele Merciaro, Patrizia Di
Gregorio, and Paola Patrignani
453
Long-Term Treatment with the Apolipoprotein Al Mimetic
Peptide Increases Antioxidants and Vascular Repair in Type I
Diabetic Rats
Stephen J. Peterson, Daniel Husney,
Adam L. Kruger, Rafal Olszanecki,
Francesca Ricci, Luigi F. Rodella,
Alessandra Stacchiotti, Rita Rezzani,
John A. McClung, Wilbert S. Aronow,
Susumu Ikehara, and Nader G. Abraham
514
Distinct Ca2+ Requirement for NO Production between
Proteinase-Activated Receptor 1 and 4 (PAR, and PAR 4) in
Vascular Endothelial Cells
Katsuya Hirano, Namie Nomoto,
Mayumi Hirano, Fumi Momota,
Akiko Hanada, and Hideo Kanaide
668
Determination of Adenosine Effects and Adenosine Receptors
in Murine Corpus Cavernosum
Rita C. Tostes, Fernanda R. C. Giachini,
Fernando S. Carneiro, Romulo Leite,
Edward W. Inscho, and R. Clinton Webb
Matthew L. Bilodeau and Heidi E. Hamm
678
Danielle lanzer, Robson Augusto Souza Santos,
Gisele Maia Etelvino, Carlos Henrique Xavier,
Jerusa de Almeida Santos,
Elizabeth Pereira Mendes,
Leonor Tapias Machado,
Benedito Carlos Prczoto, Vincent Dive, and
Antonio Carlos Martins de Camargo
795
Katja Steinkamp-Fenske, Larissa Bollinger,
Hui Xu, Ying Yao, Sven Horke,
Ulrich Fbrstermann, and Huige Li
836
Building Individualized Medicine: Prevention of Adverse
Reactions to Warfarin Therapy
BEHAVIORAL PHARMACOLOGY
Relative Abuse Liability of Indiplon and Triazolam in
Humans: A Comparison of Psychomotor, Subjective, and
Cognitive Effects
Noradrenergic Mechanisms in Cocaine-Induced Reinstatement
of Drug Seeking in Squirrel Monkeys
CARDIOVASCULAR
Human Pharmacology of Naproxen Sodium
Regulation of Protease-Activated Receptor (PAR) 1 and PAR4
Signaling in Human Platelets by Compartmentalized Cyclic
Nucleotide Actions
Do the Cardiovascular Effects of Angiotensin-Converting
Enzyme (ACE) I Involve ACE-Independent Mechanisms? New
Insights from Proline-Rich Peptides of Bothrops jararaca
Reciprocal Regulation of Endothelial Nitric-Oxide Synthase
and NADPH Oxidase by Betulinic Acid in Human Endothelial
Cells
778
CELLULAR AND MOLECULAR
PDE4B5, a Novel, Super-Short, Brain-Specific cAMP
Phosphodiesterase-4 Variant Whose Isoform-Specifying NTerminal Region Is Identical to That of cAMP
Phosphodiesterase-4D6 (PDE4D6)
U Competitive and Cooperative Effects of Bay K8644 on the LType Calcium Channel Current Inhibition by Calcium
Channel Antagonists
An Inhibitor of Casein Kinase le Induces Phase Delays in
Circadian Rhythms under Free-Running and Entrained
Conditions
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY A
Cannabinoid Anticancer Quinone, HU-331, Is More Potent and
Less Cardiotoxic Than Doxorubicin: A Comparative in Vivo
Study
ENDOCRINE AND DIABETES
Testing the Bipartite Model of the Sulfonylurea Receptor
Binding Site: Binding of A-, B-, and A + B-Site Ligands
York-Fong Cheung, Zhengyan Kan,
Philip Garrett-Engele, Irene Gall, Hannah
Murdoch, George S. Baillie, Luiz Miguel
Camargo, Jason M. Johnson, Miles D.
Houslay, and John C. Castle
600
Alexandra Zahradnfkova, Igor Minarovic,
and Ivan Zahradm'k
63K
Lori Badura, Terri Swanson, Wendy
Adamowicz, Jessica Adams, Julie
Cianfrogna, Katherine Fisher, Janice
Holland, Robin Kleiman, Frederick
Nelson, Linda Reynolds, Kristin St.
Germain, Eric Schaeffer, Barbara
Tate, and Jeffrey Sprouse
730
Natalya M. Kogan, Michael Schlesinger,
Maximilian Peters, Gergana Marincheva,
Ronen Beeri, and Raphael Mechoulam
646
Marcus Winkler, Damian Stephan, Susanne
Bieger, Petra Ktihner, Felix Wolff, and
Ulrich Quast
701
Naoko Misaki, Xia Mao, Yu-Fung Lin,
Sechiko Suga, Guo-Hui Li, Qiang Liu,
Yongchang Chang, Hai Wang, Makoto
Wakui, and Jie Wu
871
Luca Antonioli, Matteo Fornai, Rocchina
Colucci, Narcisa Ghisu, Federico Da
Settimo, Gianfranco Natale, Olga
Kastsiuchenka, Emiliano Duranti, Agostino
Virdis, Cristina Vassalle, Concertina La
Motta, Laura Mugnaint, Maria Cristina
Breschi, Corrado Blandizzi, and Mario Del
Tacca
435
Zivar Yousefipour, Hantz Hercule,
Luan Truong, Adebayo Oyekan, and
Mohammad Newaz
461
Yasuhiro Nakai, Katsuhisa Inoue, Naoki
Abe, Mai Hatakeyama, Kin-ya Ohta,
Masaki Otagiri, Yayoi Hayashi, and
Hiroaki Yuasa
469
HuiHng Liu and Jerry M. Farley, Sr.
501
Shi-Lin Du, Hong Pan, Wei-Yue Lu,
Jian Wang, Jian Wu, and Ji-Yao Wang
560
;
Iptakalim, a Vascular ATP-Sensitive Potassium (KATP) Channel
Opener, Closes Rat Pancreatic /3-Cell KAT1, Channels and
Increases Insulin Release
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
Inhibition of Adenosine Deaminase Attenuates Inflammation in
Experimental Colitis
Ciglitazone, a Peroxisome Proliferator-Activated Receptor y
Inducer, Ameliorates Renal Preglomerular Production and
Activity of Angiotensin II and Thromboxane A2 in GlycerolInduced Acute Renal Failure
Functional Characterization of Human Proton-Coupled Folate
Transporter/Heme Carrier Protein 1 Heterologously Expressed
in Mammalian Cells as a Folate Transporter
Prostaglandin E2 Enhances Acetylcholine-Induced, Ca2+-Dependent
Ionic Currents in Swine Tracheal Mucous Gland Cells
Cyclic Arg-Gly-Asp Peptide-Labeled Liposomes for Targeting
Drug Therapy of Hepatic Fibrosis in Rats
Glucuronidation Converting Methyl l-(3,4-Dimethoxyphenyf> 3(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S8921) to a Potent Apical Sodium-Dependent Bile Acid
Transporter Inhibitor, Resulting in a Hypocholesterolemic
Action
Neuronally Released Acetylcholine Acts on the M 2 Muscarinic
Receptor to Oppose the Relaxant Effect of Isoproterenol on
Cholinergic Contractions in Mouse Urinary Bladder
INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
Pharmacological Characterization of Sch527123, a Potent
Allosteric CXCR1/CXCR2 Antagonist
Shingo Sakamoto, Hiroyuki Kusuhara,
Kenji Miyata, Hiroyuki Shimaoka,
Takushi Kanazu, Yumiko Matsuo,
Kohji Nomura, Noboru Okamura,
Seijiro Hara, Kazutoshi Horie,
Takahiko Baba, and Yuichi Sugiyama
Frederick J. Ehlert, Simon Ahn, Kirk J. Pak,
Grace J. Park, Marline S. Sangnil, John A.
Tran, and Minoru Matsui
Waldemar Gonsiorek, Xuedong Fan,
David Hesk, James Fossetta, Hongchen Qiu,
James Jakway, Motasim Billah,
Michael Dwyer, Jianhua Chao,
Gregory Deno, Art Taveras,
Daniel J. Lundell, and R. William Hipkin
610
631
477
A Novel, Orally Active CXCR1/2 Receptor Antagonist,
Sch527123, Inhibits Neutrophil Recruitment, Mucus
Production, and Goblet Cell Hyperplasia in Animal Models of
Pulmonary Inflammation
Richard W. Chapman, Michael Minnicozzi,
Chander S. Celly, Jonathan E. Phillips,
Ted T. Kung, R. William Hipkin,
Xnedong Fan, Diane Rindgen,
Gregory Deno, Richard Bond,
Waldemar Gonsiorek, Motasim M. Billah,
Jay S. Fine, and John A. Hey
486
Tumor Necrosis Factor (TNF)-Soluble High-Affinity Receptor
Complex as a TNF Antagonist
Sean D. McKenna, Georg Feger,
Christie Kelton, Meijia Yang, Vittoria
Ardissone, Rocco Cirillo, Pierre-Alain
Vitte, Xuliang Jiang, and Robert K.
Campbell
822
Naoki Kobayashi, Hitomi Kobayashi,
Leo Gu, Thomas Malefyt, and
Teruna J. Siahaan
Karen Santora, Cordelia Rasa, Denise Visco,
Bernard G. Steinetz, and Carol A. Bagnell
879
\s\ Antigen-Specific Suppression of Experimental Autoimmune
Encephalomyelitis by a Novel Bifunctional Peptide Inhibitor
Antiarthritic Effects of Relaxin, in Combination with
Estrogen, in Rat Adjuvant-Induced Arthritis
METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
(s] Human Hydroxysteroid Sulfotransferase SULT2B1
Pharmacogenomics: Gene Sequence Variation and Functional
Genomics
Transport of Paraquat by Human Organic Cation
Transporters and Multidrug and Toxic Compound Extrusion
Family
Applicability of the Dopamine and Rate Hypotheses in
Explaining the Differences in Behavioral Pharmacology of the
Chloro-Benztropine Analogs: Studies Conducted Using
Intracerebral Microdialysis and Population Pharmacodynamic
Modeling
Impaired Microsomal Oxidation of the Atypical Antipsychotic
Agent Clozapine in Hepatic Steatosis
Flavonoid Glycosides Are Not Transported by the Human
NaVGlucose Transporter When Expressed in Xenopus laevis
Oocytes, but Effectively Inhibit Electrogenic Glucose Uptake
Dehydrogenation of Indoline by Cytochrome P450 Enzymes:
A Novel "Aromatase" Process
NEUROPHARMACOLOGY
Activation of a Novel Injury-Induced Calcium-Permeable
Channel That Plays a Key Role in Causing Extended
Neuronal Depolarization and Initiating Neuronal Death in
Excitotoxic Neuronal Injury
Effects of Lamotrigine Alone and in Combination with MK801, Phenobarbital, or Phenytoin on Cell Death in the
Neonatal Rat Brain
The Effect of Recombinant Human Erythropoietin on
Neurovasculature Repair after Focal Ischemic Stroke in
Neonatal Rats
Pharmacokinetics and Amyloid Plaque Targeting Ability of a
Novel Peptide-Based Magnetic Resonance Contrast Agent in
Wild-Type and Alzheimer's Disease Transgenic Mice
Antiepileptic Drugs Affect Neuronal Androgen Signaling via a
Cytochrome P450-Dependent Pathway
\s\ Benzodiazepine Withdrawal-Induced Glutamatergic Plasticity
Involves Up-Regulation of GluRl-Containing a-Amino-3hydroxy-5-methylisoxazole-4-propionic Acid Receptors in
Hippocampal CA1 Neurons
Atrial Natriuretic Peptide Reduces Ischemia/ReperfusionInduced Spinal Cord Injury in Rats by Enhancing Sensory
Neuron Activation
Galantamine Postischemia Provides Neuroprotection and
Memory Recovery against Transient Global Cerebral
Ischemia in Gerbils
887
Yuan Ji, Irene Moon, Jelena Zlatkovic,
Oreste E. Salavaggione, Bianca A. Thomae,
Bruce W. Eckloff, Eric D. Wieben, Daniel J.
Schaid, and Richard M. Weinshilboum
529
Ying Chen, Shuzhong Zhang, Marco Sorani,
and Kathleen M. Giacomini
695
Ahmed A. Othman, Amy Hauck Newman,
and Natalie D. Eddington
760
Wei V. Zhang, Iqbal Ramzan, and
Michael Murray
770
Gabor Kottra and Hannelore Daniel
829
Hao Sun, William J. Ehlhardt,
Palaniappan Kulanthaivel, Diane L. Lanza,
Christopher A. Reilly, and Garold S. Yost
843
Laxmikant S. Deshpande,
David D. Limbrick, Jr., Sompong Sombati,
and Robert J. DeLorenzo
443
Irina Katz, Jinsook Kim, Karen Gale, and
Alexei Kondratyev
494
Christine L. Keogh, Shan Ping Yu, and
Ling Wei
521
Karunya K. Kandimalla,
Thomas M. Wengenack, Geoffry L. Curran,
Emily J. Gilles, and Joseph F. Poduslo
541
Marcel Gehlhaus, Nina Schmitt,
Benedikt Volk, and Ralf P. Meyer
550
Jun Song, Guofu Shen,
L. John Greenfield, Jr., and
Elizabeth I. Tietz
569
Takuya Nakayama, Naoaki Harada,
Miki Asano, Norikazu Nomura,
Takayuki Saito, Akira Mishima, and
Kenji Okajima
582
Silvia Lorrio, Monica Sobrado,
Esperanza Arias, Jose M. Roda,
Antonio G. Garcia, and Manuela G. Lopez
591
Pharmacological, Pharmacokinetic, and Primate Analgesic
Efficacy Profile of the Novel Bradykinin B x Receptor
Antagonist ELN441958
Sexually Dimorphic Recruitment of Spinal Opioid Analgesic
Pathways by the Spinal Application of Morphine
Jon E. Hawkinson, Balazs G. Szoke,
Albert W. Garofalo, Dennis S. Horn,
Hongbing Zhang, Mark Dreyer,
Juri Y. Fukuda, Linda Chen,
Bhushan Samant, Stellanie Simmonds,
Karla P. Zeitz, Angie Wadsworth,
Anna Liao, Raymond A. Chavez,
Wes Zmolek, Lany Ruslim,
Michael P. Bova, Ryan Holcomb,
Eduardo R. Butelman, Mei-Chuan Ko, and
Annika B. Malmberg
Nai-Jiang Liu, Hans von Gizycki, and
Alan R. Gintzler
619
654
Low Sensitivity of the Positron Emission Tomography Ligand
("CjDiprenorphine to Agonist Opiates
Susan P. Hume, Anne R. Lingford-Hughes,
Valerie Nataf, Ella Hirani, Rabia Ahmad,
Andrew N. Davies, and David J. Nutt
661
CJ-023,423, a Novel, Potent and Selective Prostaglandin EP 4
Receptor Antagonist with Antihyperalgesic Properties
Kazunari Nakao, Akio Murase,
Hiroyuki Ohshiro, Takako Okumura,
Kana Taniguchi, Yoko Murata,
Masatoshi Masuda, Tomoki Kato,
Yoshiyuki Okumura, and Junji Takada
686
Identification and Characterization of Cholest~4-en-3-one,
Oxime (TRO19622), a Novel Drug Candidate for Amyotrophic
Lateral Sclerosis
Thierry Bordet, Bruno Buisson,
Magali Michaud, Cyrille Drouot,
Pascale Gal6a, Pierre Delaage,
Natalia P. Akentieva, Alex S. Evers,
Douglas F. Covey, Mariano A. Ostuni,
Jean-Jacques Lacapere, Charbel Massaad,
Michael Schumacher, Esther-Marie Steidl,
DeiphineMaux, Michel Delaage,
Christopher E. Henderson, and
Rebecca M. Pruss
709
721
Neuroprotection with Erythropoietin Administration
Following Controlled Cortical Impact Injury in Rats
Michela Giustizieri,
Maria Letizia CucchiaronL Ezia Guatteo,
Giorgio Bernardi, Nicola B. Mercuri, and
Nicola Berretta
Sensitization and Activation of Intracranial Meningeal
Nociceptors by Mast Cell Mediators
C. Thetford Smothers and John J. Woodward
739
Leela Cherian, J. Clay Goodman, and
Claudia Robertson
789
Xi-Chun Zhang, Andrew M. Strassman,
Rami Burstein, and Dan Levy
806
Kenneth T. Sykes, Stephanie R. White,
Robert W. Hurley, Hirokazu Mizoguchi,
Leon F. Tseng, and Donna L. Hammond
813
Luis R. Gardell, Kimberly E. Vanover,
Linda Pounds, Robert W. Johnson,
Richard Barido, Gary T. Anderson,
Isaac Veinbergs, Agnete Dyssegaard,
Per Brunmark, Ali Tabatabaei,
Robert E. Davis, Mark R. Brann,
Uli Hacksell, and Douglas W. Bonhaus
862
Xiaomin Deng, James P. Luyendyk,
Wei Zou, Jingtao Lu, Ernst Malle,
Patricia E. Ganey, and Robert A. Roth
852
Memantine Inhibits ATP-Dependent K+ Conductances in
Dopamine Neurons of the Rat Substantia Nigra Pars Compacta
Pharmacological Characterization of Glycine-Activated
Currents in HEK 293 Cells Expressing 7V-Methyl-D-aspartate
NR1 and NR3 Subunits
Mechanisms Responsible for the Enhanced Antinociceptive
Effects of /t-Opioid Receptor Agonists in the Rostral
Ventromedial Medulla of Male Rats with Persistent
Inflammatory Pain
ACP-103, a 5-Hydroxytryptamine 2A Receptor Inverse Agonist,
Improves the Antipsychotic Efficacy and Side-Effect Profile of
Haloperidol and Risperidone in Experimental Models
TOXICOLOGY
Neutrophil Interaction with the Hemostatic System
Contributes to Liver Injury in Rats Cotreated with
Lipopolysaccharide and Ranitidine