May 2006
Vol. 317, No. 2
ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION
Recognition, Cointernalization, and Recycling of an Avian
Riboflavin Carrier Protein in Human Placental Trophoblasts
Clifford W. Mason, Vanessa M. D'Souza,
Lisa M. Bareford, Mitch A. Phelps, Abhijit
Ray, and Peter W. Swaan
Phenobarbital Treatment Inhibits the Formation of Estradiol-
Dependent Mammary Tumors in the August-Copenhagen Irish
Rat
Verapamil P-glycoprotein Transport across the Rat Blood-Brain
Barrier: Cyclosporine, a Concentration Inhibition Analysis, and
Comparison with Human Data
Sonia Mcsia-Vela, Rosa I. Sanchez, Kenneth
R. Reuhl, Allan H. Conney, and Frederick C.
Kauffman
Differential Effects of Passive Immunization with Nicotine-Specific P. R. Pentel, M. B. Dufek, S. A. Roiko,
Antibodies on the Acute and Chronic Distribution of Nicotine to M. G. LeSage, and D. E. Keyler
Brain in Rats
Roie of Site-Specific Binding to Plasma Albumin in Drug
Availability to Brain
Haritha Mandula, Jagan Mohan R. Parepally,
Rose Feng, and Quentin R. Smith
Peng Hsiao, Lucy Sasongko, Jeanne M.
Link, David A. Mankoff, Mark Muzi,
Ann C. Collier, and Jashvant D.
Unadkat
In Vitro Metabolism of (Nitrooxy)butyl Ester Nitric Oxide-
Releasing Compounds: Comparison with Glyceryl Trinitrate
Enhanced Hepatic Uptake and Bioactivity of Type al(I) Collagen
Gene Promoter-Specific Triplex-Forming Oligonucleotides after
Conjugation with Cholesterol
Characterization of P-glycoprotein Inhibition by Major
Cannabinoids from Marijuana
Transport Is Not Rate-Limiting in Morphine Glucuronidation in the Single-Pass Perfused Rat Liver Preparation
Mirco Govoni, Simona Casagrande,
Raffaella Maucci, Valerio Chiroli, and
Paola Tocchetti
Kun Cheng, Zhaoyang Ye,
Ramareddy V. Guntaka, and Ram I. Mahato
Hao-Jie Zhu, Jun-Sheng Wang, John S.
Markowitz, Jennifer L. Donovan, Bryan B.
Gibson, Holly A. Gefroh, and C. Lindsay
DeVane
Margaret M. Doherty, Karen Poon,
Carol Tsang, and K. Sandy Pang
BEHAVIORAL PHARMACOLOGY
Choice between Heroin and Food in Nondependent and Heroin-
Dependent Rhesus Monkeys: Effects of Naloxone, Buprenorphine, and Methadone
S. Stevens Negus
Peripheral Administration of a Melanocortin 4-Receptor Inverse
Agonist Prevents Loss of Lean Body Mass in Tumor-Bearing
Mice
Janet R. Nicholson, Gotz Kohler,
Florian Schaerer, Claudia Senn,
Philipp Weyermann, and Karl G. Hofbauer
Modafinil [2-[(Diphenylmethyl)sulfinyIJacetamide] and Circadian
Rhythms in Syrian Hamsters: Assessment of the Chronobiotic
Potential of a Novel Alerting Compound
Ian C. Webb, Michael S. Pollock, and
Ralph E. Mistlberger
465
590
660
667
704
752
797
850
890
711
771
882

CARDIOVASCULAR
Pharmacological and Electrophysiologieal Characterization of
Store-Operated Currents and Capacitative Ca 24 ~ Entry in
Vascular Smooth Muscle Cells
Metalloproteinase Inhibitor Counters High-Energy Phosphate
Depletion and AMP Deaminase Activity Enhancing
Ventricular Diastolic Compliance in Subacute Heart Failure
D-Propranolol Attenuates Lysosomal Iron Accumulation and
Oxidative Injury in Endothelial Cells
/3 a
Adrenergic Stimulation Attenuates Left Ventricular
Remodeling, Decreases Apoptosis, and Improves Calcium
Homeostasis in a Rodent Model of Ischemic Cardiomyopathy
Melittin Inhibits Vascular Smooth Muscle Cell Proliferation through Induction of Apoptosis via Suppression of Nuclear
Factor-icB and Akt Activation and Enhancement of Apoptotic
Protein Expression
NADPH-Induced Contractions of Mouse Aorta Do Not
Involve NADPH Oxidase: A Role for P2X Receptors
Peroxisome Proliferator-Activated Receptor a and y Ligands
Differentially Affect Smooth Muscle Cell Proliferation and
Migration
Evidence for a Control of Plasma Serotonin Levels by 5-
Hydroxytryptamine
2B
Receptors in Mice
Induction of Renal Cytoehrome P450 Arachidonic Acid
Epoxygenase Activity by Dietary y-Linolenic Acid
Segmental Differences in the Roles of Rho-Kinase and Protein
Kinase C in Mediating Vasoconstriction
Clovamide-Type Phenylpropenoie Acid Amides, N-
Coumaroyldopamine and /V-Caffeoyldopamine, Inhibit
Platelet-Leukocyte Interactions via Suppressing P-Selectin
Expression
Pharmacological Characterization of 2NTX-99 [4-Mcthoxy-iV 1 -
(4-/rarts-nitrooxycyclohexyl)-iV 3 -(3-pyridinyImetliyl)-1,3benzenedicarboxamide], a Potential Antiatherothrombotic
Agent with Antithromboxane and Nitric Oxide Donor Activity in Platelet and Vascular Preparations
Molecular Determinants of Cocaine Block of Human Ether-d- go-gw-Related Gene Potassium Channels
CELLULAR AND MOLECULAR
Rescue of AF508-CFTR (Cystic Fibrosis Transmembrane
Conductance Regulator) by Curcumin: Involvement of the
Keratin 18 Network
Characterization of Mice Lacking the Multidrug Resistance
Protein Mrp2 (Abcc2)
Lioubov I. Brueggemann, Daniel R. Markun,
Kyle K. Henderson, Leanne L. Cribbs, and
Kenneth L. Byron
Nazareno Paolocci, Barbara Tavazzi,
Roberto Biondi, Yehezkiel A. Gluzband,
Angela Maria Amorini, Carlo G. Tocchetti,
Mehrdad Hejazi, Patrizio M. CaturegH,
Jan Kajstura, Giuseppe Lazzarino, and
David A. Kass
I. Tong Mak, Joanna J. Chmielinska,
Lucie Nedelec, Armida Torres, and
William B. Weglicki
Steve Xydas, Aftab R. Kherani,
Jonathan S. Chang, Stefan Klotz, Ilan Hay,
Christopher J. Mutrie, Garrett W. Moss, Anguo
Gu, Allison R. Schulman, Daqing Gao, Debora
Hu, Ed X. Wu, Chiming Wei, Mehmet C. Oz, and Jie Wang
Dong .lu Son, Seong Jong Ha,
Ho Sueb Song, Yong Lim, Yeo Pyo Yun, Jae
Woong Lee, Dong Cheul Moon, Young Hyun
Park, Byeoung Soo Park, Min Jong Song, and
Jin Tae Hong
Courtney P. Judkins, Christopher G. Sobey,
Thuy T. Dang, Alyson A. Miller,
Gregory J. Dusting, and Grant R. Drummond
Peter Zahradka, Brenda Wright,
Melissa Fuerst, Natalia Yurkova,
Katerina Molnar, and Carla G. Taylor
J. Callebert, J. M. Estevc,
P. Herve, K. Peoc'h, C. Tournois, L. Drouet, J.
M. Launay, and L. Maroteaux
Zhigang Yu, Valerie Y. Ng, Ping Su,
Marguerite M. Engler, Mary B. Engler,
Yong Huang, Emil Lin, and Deanna L.
Kroetz
Klaudia Budzyn, Michelle PaulU
Philip D. Marley, and Christopher G. Sobey
Jae B. Park and Norberta Schocne
Carola Buccellati, Angelo Sala,
Giuseppe Rossoni, Valerie Capra,
G. Enrico Rovati, Antonio Di Gennaro,
Giancarlo Folco, Susanna Colli, and
Cesare Casagrande
Jun Guo, Hongying Gang, and
Shetuan Zhang
Joanna Lipecka, Caroline Norez,
Noura Bensalem, Maryvonne Baudouin-
Legros, Gabrielle Planelles, Frederic Becq,
Aleksander Edelman, and Noelie Davezac
Xiao-Yan Chu, John R. Strauss,
Michele A. Mariano, Jing Li,
Deborah J. Newton, Xiaoxin Cai,
Regina W. Wang, Jocelyn Yabut,
Dylan P. Hartley, David C. Evans, and
Raymond Evers
Michael Saborowski, Gerd A. Kullak-Ublick, and Jyrki J. Eloranta
The Human Organic Cation Transporter-1 Gene Is
Transactivated by Hepatocytc Nuclear Factor-4a
488
506
522
553
627
644
651
724
732
791
813
830
865
500
579
778

Comparison of the Relative Efficacy and Potency of ju,-Opioid
Agonists to Activate G« i/O
Proteins Containing a Pertussis
Toxin-Insensitive Mutation
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
Actions of a Histone Deacetylase Inhibitor NSC3852 (5-
Nitroso-8-quinolinoI) Link Reactive Oxygen Species to Cell
Differentiation and Apoptosis in MCF-7 Human Mammary
Tumor Cells
ENDOCRINE AND DIABETES
A Novel Partial Agonist of the A
T
-Adenosine Receptor and
Evidence of Receptor Homogeneity in Adipocytes
Mary J. Clark, Cherysc A. Furman.
Timra D. Gilson, and John R. Traynor
Anna Martirosyan. Stephen Leonard,
Xianglin Shi, Brian Griffith, Peter Gannett, and Jeannine Strobl
Marjan Fatholahi, Yiwen Xiang, Yuzhi Wu,
Yuan Li, Lin Wu, Arvinder K. Dhalla, Luiz
Belardinelli, and John C. Shryock
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
Theophylline Improves Early Allograft Function in Rat
Kidney Transplantation
The Antiproliferative Drug Doxorubicin Inhibits Liver
Fibrosis in Bile Duct-Ligated Rats and Can Be Selectively
Delivered to Hepatic Stellate Cells in Vivo
Platelet Aggregation-Induced by Caco-2 Cells: Regulation by
Matrix Metalioproteinase-2 and Adenosine Diphosphate
In Vitro and in Vivo Pharmacological Characterization of 5-
[(ff)-2-(5,6-Diethyl-indan-2-ylamino)-l-hydroxy-ethyll-8hydroxy-l//-quinolin-2-one (Indacaterol), a Novel Inhaled fi
2
Adrenoccptor Agonist with a 24-h Duration of Action
Almut Grenz, Detlef Baier, Fotios
Petroktistis, Manfred Wehrmann,
Christoph Kohle, Martin Schenk, Michael
Sessler, Christoph H. Gleiter, Fred
Fandrich, and Hartmut Osswald
Rick Greupink, Hester I. Bakker, Wilma
Bouma, Catharina Reker-Smit, Dirk K. F.
Meijer, Leonie Beljaars, and Klaas
Poelstra
Carlos Medina, Paul Jurasz,
Maria Jose Santos-Martinez,
Soon Seog Jeong, Timothy Mitsky,
Ridong Chen, and Marek W. Radomski
Cliff Batlram, Steven J. Charlton, Bernard
Cnenoud, Mark R. Dowling, Robin A.
Fairhurst, David Farr, John R. Fozard,
Juliet R. Leighton-Davies, Christine A.
Lewis, Lorraine McEvoy, Robert J.
Turner, and Alexandre Trifilieff
INFLAMMATION AND IMMUNOPHARMACOLOGY
A Novel Spleen Tyrosine Kinase Inhibitor Blocks c-Jun N-
Terminal Kinase-Mediated Gene Expression in Synoviocytes
Hoon-Suk Cha, David L. Boyle,
Tomoyuki Inoue, Reineke Schoot,
Paul P. Tak, Polly Pine, and Gary
S. Firestein
Hugh T. Abey, David P. Fairlie,
James D. Moffatl, Rowan W. Balzary, and
Thomas M. Cocks
Rowan W. Balzary and Thomas M. Cocks
Protease-Activated Receptor-2 Peptides Activate Neurokinin-1
Receptors in the Mouse Isolated Trachea
Lipopolysaccharide Induces Epithelium- and Prostaglandin
E
2
-Dependent Relaxation of Mouse Isolated Trachea through
Activation of Cyclooxygenase (COX)-l and COX-2
Cannabinoid-Mediated Elevation of Intracellular Calcium: A
Structure-Activity Relationship
NEUROPHARMACOLOGY
Clozapine Modulates Aromatic L-Amino Acid Decarboxylase
Activity in Mouse Striatum
3- [2- [4- (3- Chloro-2-meth ylphenylmethyl)-1 -piperazinyl] ethy 1] -
5,6-dimethoxy-l-(4-imidazoIylmethyI)-l/f-indazole dihydrochloride 3.5 Hydrate (DY-9760e) Is Neuroprotective in Rat
Microsphere Embolism: Role of the Cross-Talk between
Calpain and Caspase-3 through Calpastatin
Pharmacological Characterization and Feeding-Suppressive
Property of FMS586 [3-(5,6,7,8-Tetrahydro-9-isopropylcarbazol-3-yl)-1 -methyl-1- (2-py ridin-4-y 1-ethy l)-urea
Hydrochloride], a Novel, Selective, and Orally Active
Antagonist for Neuropeptide Y Y5 Receptor
Interaction with a
Y
Protein, but Not iV-Methyl-D-aspartate
Receptor, Is Involved in the Pharmacological Activity of
Donepezil
Gautham K. Rao and Norbert Fi. Kaminski
Norton H. Neil, Trina A. Wcmlinger,
Anne-Marie Duchemin, and Maria
Hadjiconstantinou
Feng Han, Yasufumi Shirasaki, and
Kohji Fukunaga
Nobukazu Kakui, Jiro Tanaka, Yuji Tabata,
Kenji Asai, Naomi Masuda, Takako Miyara,
Yuko Nakatani, Fukuichi Ohsawa, Naoyuki
Nishikawa, Masaharu Sugai, Makoto
Suzuki, Kozo Aoki, and Hiroshi Kitaguchi
Tangui Maurice, Johann Meunier,
Bihua Feng, John Ieni, and Daniel
T. Monaghan
85K
546
676
473
562
606
514
739
762
571
598
806
820
4K0
529

The in Vivo Contributions of TASK-1-Containing Channels to the Actions of Inhalation Anesthetics, the a.
2
Adrenergic
Sedative Dexmedetomidine, and Cannabinoid Agonists
Regulation of Volume-Sensitive Osmolyte Efflux from Human
SH-SY5Y Neuroblastoma Cells following Activation of
Lysophospholipid Receptors
The Pheromone Androstenol (5asAndrost-16-en-3o:-ol) Is a
Neurosteroid Positive Modulator of GABA
A
Receptors
Nevirapine Uptake into the Central Nervous System of the
Guinea Pig: An in Situ Brain Perfusion Study
In Vivo Characterization of A/3(40) Changes in Brain and
Cerebrospinal Fluid Using the Novel y-Secretase Inhibitor /V-
[as-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5difluorophenyl)cyclohexyl]-l,14-trifluoromethanesulfonamide
(MRK-560) in the Rat
Repeated Adolescent 3,4-Methylenedioxymethamphetamine
(MDMA) Exposure in Rats Attenuates the Effects of a
Subsequent Challenge with MDMA or a 5-
Hydroxytryptamine
1A
Receptor Agonist
Therapeutic Time Window and Dose Dependence of
Neuroprotective Effects of Sodium Orthovanadate following
Transient Middle Cerebral Artery Occlusion in Rats
\s\ Reversal of Morphine Antinociceptive Tolerance and
Dependence by the Acute Supraspinal Inhibition of
Ca 2+ /Calmodulin-Dependent Protein Kinase II
Pharmacological and Behavioral Profile of JV-(4-
Fluorophenylmethyi)-iV-( 1 -methylpiperidin-4-yl)-A'' - (4 methylpropyloxy)phenylmethyl) Carbamide (2R,3R)-
Dihydroxybutanedioate (2:1) (ACP-103), a Novel 5-
Hydroxytryptamine
2X
Receptor Inverse Agonist
Anni-Maija Linden, M. Isabel Aller, Elli
Leppa, Olga Vekovischeva, Teemu
Aitta-aho, Emma L. Veale, Alistair
Mathie, Per Rosenberg, William Wisden, and Esa R. Korpi
Anne M. Heacock, Michael S. Dodd,
Stephen K. Fisher and
Ratal M. Kaminski, Herbert Marini,
Pavel 1. Ortinski, Stefano Vicini, and
Michael A. Rogawski
J. E. Gibbs, Z. Gaffen, and S. A. Thomas
Jonathan D. Best, Mark T. Jay, Franklin Otu,
Ian Churcher, Michael Reilly, Pablo
Morentin-Gutierrez, Christine Pattison, Tim
Harrison, Mark S. Shearman, and John R.
Atack
Brian J. Piper, Huyen L. Vu,
Mina G. Safain, Andrew J. Oliver, and
Jerrold S. Meyer
Yu Hasegawa, Motohiro Morioka, Shu
Hasegawa, Jun Matsumoto, Takayuki
Kawano, Yutaka Kai, Shigetoshi Yano,
Kohji Fukunaga, and Jun-ichi Kuratsu
Lei Tang, Pradeep K. Shukla, Lili X. Wang, and Zaijie Jim Wang
Kimberly E. Vanover, David M. Weiner,
Malath Makhay, Isaac Veinbergs, Luis R.
Gardell, Jelvch Lameh, Andria L. Del
Tredici, Fabrice Piu, Hans H. Schiffer,
Thomas R. Ott, Ethan S. Burstein, Allan K.
Uldam, Mikkel B. Thygesen, Nathalie
Schlienger, Carl Magnus Andersson, Thomas
Y. Son, Scott C. Harvey, Susan B. Powell,
Mark A. Geyer, Bo-Ragner Tolf, Mark R.
Brann, and Robert E. Davis
TOXICOLOGY
\s] Induction of Hepatic Transporters Multidrug Resistance-
Associated Proteins (Mrp) 3 and 4 by Clofibrate Is Regulated by Peroxisome Proliferator-Activated Receptor a
EH Coagulation-Dependent Gene Expression and Liver Injury in
Rats Given Lipopolysaccharide with Ranitidine but Not with
Famotidine
Jeffrey S. Moffit, Lauren M. Aleksunes,
Jonathan M, Maher, George L. Schcffer,
Curtis D. Klaassen, and Jose E. Manaulou
James P. Luyendyk,
Lois D. Lehman-McKeeman,
David M. Nelson. Vasanthi M. Bhaskaran,
Timothy P. Reilly, Bruce D. Car,
Glenn H. Cantor, Xiaomin Deng,
Jane F. Maddox, Patricia E. Ganey, and
Robert A. Roth
ERRATUM
Correction to "Antipsychotic Dosing in Prcclinical Models Is
Often Unrepresentative of the Clinical Conditions: A
Suggested Solution Based on in Vivo Occupancy"
Shitij Kapur, Susan C. VanderSpek,
Barbara A. Brownlee, and Jose N. Nobreg
615
838
875
919
685
694
746
786
901
910
537
635