July 2006 Vol. 318, No. 1
PERSPECTIVES IN PHARMACOLOGY
Alcohol Use, Vascular Disease, and Lipid-Lowering Drugs
Genovefa D. Kolovou, Klelia D. Salpea,
Katherine K. Anagnostopoulou, and
Dimitri P. Mikhailidis
BEHAVIORAL PHARMACOLOGY
Antinociceptive Pharmacology of iV-[[4-(4,5-Dihydro-lffimidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6dimethylphenyl) sulfonyl]methylamino]ethoxy]-A'methylacetamide, Fumarate (LF22-0542), a Novel Nonpeptidic
Bradykinin B, Receptor Antagonist
Relative Reinforcing Effects of Cocaine, Remifentanil, and
Their Combination in Rhesus Monkeys
Endogenous Orphanin FQ/Nociceptin Is Involved in the
Development of Morphine Tolerance
CARDIOVASCULAR
Induction of Heme Oxygenase-1 Is Involved in Carbon
Monoxide-Mediated Central Cardiovascular Regulation
Pleiotropic Effects of the J3-Adrenoceptor Blocker Carvedilol on Calcium Regulation during Oxidative Stress-Induced
Apoptosis in Cardiomyocytes
Role of Phosphorus and Vitamin D Analogs in the
Pathogenesis of Vascular Calcification
F. Porreca, T. W. Vanderah, W. Guo,
M. Barth, P. Dodey, V. Peyrou,
J. M. Luccarini, J.-L. Junien, and D. Pruneau
G. Winger, C. M. Galuska, S. R. Hursh, and
J. H. Woods
Shinjae Chung, Sigrun Pohl, Joanne Zeng,
Olivier Civelli, and Rainer K. Reinscheid
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262
Wan-Chen Lo, Pei-Jung Lu, Wen-Yu Ho, 8
Michael Hsiao, and Ching-Jiunn Tseng
45 Ruijuan Wang, Toshiro Miura,
Nozomu Harada, Ryosuke Kametani,
Masaki Shibuya, Yasuhiro Fukagawa, Shuji
Kawamura, Yasuhiro Ikeda, Masayuki Hara, and Masunori Matsuzaki
90 J. Ruth Wu-Wong, William Noonan,
Junli Ma, Doug Dixon, Masaki Nakane,
Antoinette L. Bolin, Kristin A. Koch, Steve
Postl, Sherry J. Morgan, and Glenn A.
Reinhart
Sung-Sik Park, Hong Zhao, Yeongho Jang,
Robert A. Mueller, and Zhelong Xu
124 A^-(3-Iodobenzyl)-adenosine-5'-iV-niethylcarboxamide Confers
Cardioprotection at Reperfusion by Inhibiting Mitochondrial
Permeability Transition Pore Opening via Glycogen Synthase
Kinase 3/3
Volatile Anesthetic Preconditioning Attenuates Myocardial
Apoptosis in Rabbits after Regional Ischemia and Reperfusion via Akt Signaling and Modulation of Bcl-2 Family Proteins
Blocking Late Sodium Current Reduces Hydrogen Peroxide-
Induced Arrhythmogenic Activity and Contractile Dysfunction
Jacob Raphael, Suzan Abedat, Julia Rivo,
Karen Meir, Ronen Been, Thea Pugatsch,
Zhiyi Zuo, and Yaacov Gozal
Yejia Song, John C. Shryocfc,
Stefan Wagner, Lars S. Maier, and
Luiz Belardinelli
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214

Central Adenosine Signaling Plays a Key Role in Centrally
Mediated Hypotension in Conscious Aortic Barodenervated Rats
Augmented Endothelium-Derived Hyperpolarizing Factor-
Mediated Relaxations Attenuate Endothelial Dysfunction in
Femoral and Mesenteric, but Not in Carotid Arteries from
Type r Diabetic Rats
Increased RhoA/Rho-Kinase Signaling Mediates Spontaneous
Tone in Aorta from Angiotcnsin II-Induced Hypertensive Rats
Synthetic Peroxisome Proliferator-Activated Receptor-y
Agonists Restore Impaired Vasorelaxation via ATP-Sensitive
K + Channels by High Glucose
Sesamin Metabolites Induce an Endothclial Nitric Oxide-
Dependent Vasorelaxation through Their Antioxidative
Property-Independent Mechanisms: Possible Involvement of the Metabolites in the Antihypertensive Effect of Sesamin
The Emerging Cardioinhibitory Role of the Hippocampal
Cholinergic Neurostimulating Peptide
Differentiation of Arrhythmia Risk of the Antibacterials
Moxifloxacin, Erythromycin, and Telithromycin Based on
Analysis of Monophasic Action Potential Duration Alternans and Cardiac Instability
Improved Left Ventricular Function and Reduced Necrosis after Myocardial Ischemia/Reperfusion in Rabbits Treated with Ranolazine, an Inhibitor of the Late Sodium Channel
CELLULAR AND MOLECULAR p53 Suppression of Arsenite-Induced Mitotic Catastrophe Is
Mediated by p
21 CIP1/WAF1
Noha Nassar and Abdel A. Abdel-Rahman
Yi Shi, David D. Ku, Ricky Y. K. Man, and
Paul M. Vanhoutte
Liming Jin, Zhekang Ying,
Rob H. P. Hilgers, Jia Yin, Xueying Zhao,
John D. Imig, and R. Clinton Webb
Hiroyuki Kinoshita, Toshiharu Azma,
Hiroshi tranami, Katsutoshi Nakahata,
Yoshiki Kimoto, Mayuko Dojo,
Osafumi Yuge, and Yoshio Hatano
Daisuke Nakano, Chol-Jun Kwak, Kiwako
Fujii, Kenjj Ikemura, Aiko Satakc, Mamoru
Ohkita, Masanori Takaoka, Yoshiko Ono,
Masaaki Nakai. Namino Tomimori,
Yoshinobu Kiso, and Yasuo Matsumura
Tommaso Angelone, Yannick Goumon,
Maria Carmela Cerra, Marie-Helene Metz-
Boutiguc, Dominique Aunis, and Bruno Tota
Todd Wisialowski. Kimbcrly Criinin,
Juntyma Engtrakul, John O'Donnell,
Bernard Fermini, and Anthony A. Fossa
Sharon L, Hale, Justin A. Lceka, and
Robert A, Kloncr
Augmentation of Ca v
3.2 T-Type Calcium Channel Activity by cAMP-Dependent Protein Kinase A
Subtype-Specific Inhibition of Nicotinic Acetylcholine
Receptors by Choline: A Regulatory Pathway
Role of Phosphatidylinositol 3-Kinase/AKT as a Survival
Pathway against CYP2K1 -Dependent Toxicity
Protein Kinase C5 Mediates Platelet-Induced Breast Cancer
Cell Invasion
B. Frazier Taylor, Samuel C. McNeely,
Heather L. Miller, Geniece M. Lchmann,
Michael J. McCabe, Jr., and J. Christopher
States
Jin-Ah Kim, Jin-Yong Park, Ho-Won Kang,
Sung-Un Huh, Seong-Woo Jeong, and Jung-
Ha Lee
Manickavasagom Alkondon and
Edson X. Albuquerque
Andres A. Caro and Arthur I. Cederbaum
David Alonso-Escolano, Carlos Medina,
Katarzyna Cieslik, Anna Radomski, Paul
Jurasz, Maria Jose Santos-Martinez, Tilahum
Jiffar. Peter Ruvolo, and Marek W.
Radomski
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
Inhibition of Protein Kinase c-Src Reduces the Incidence of
Breast Cancer Metastases and Increases Survival in Mice:
Implications for Therapy
Blockade of Angiogenesis by Small Molecule Antagonists to
Protease-Activated Receptor-1: Association with Endothelial
Cell Growth Suppression and Induction of Apoptosis
Nadia Rucci, Irene Recchia,
Adriano Angelucci, Marina Alamanou,
Andrea Del Faitore, Dario Fortunati,
Mira Susa, Doriano Fabbro, Mauro Bologna, and Anna Teti
Panagiota Zania, Sosanna Kritikou,
Christodoulos S. Flordellis, Michael
E. Maragoudakis, and Nikos E.
Tsopanoglou
ENDOCRINE AND DIABETES
Cilostazol Protects Diabetic Rats from Vascular Inflammation via Nuclear Factor-KB-Dependent Down-Regulation of
Vascular Cell Adhesion Molecule-1 Expression
Ling Gao,
Jiajun Zhao
Furong Wang, Bo Wang,
Bendi Gong, Jie Zhang, Xiumei Zhang, and
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418
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360
373

Preventive and Therapeutic Potential of p38«-Selective
Mitogen-Activated Protein Kinase inhibitor in Nonobese
Diabetic Mice with Type 1 Diabetes
Differential Modulation of Ca v
1.2 and Ca v
1.3-Mediated
Glucose-Stimulated Insulin Secretion by cAMP in INS-1 Cells:
Distinct Roles for Exchange Protein Directly Activated by cAMP 2 (Epac2) and Protein Kinase A
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
Iinmunomodulatory Therapeutic Effect of Glatiramer Acetate on Several Murine Models of Inflammatory Bowel Disease
Salyanarayana Medicherla,
Andrew A. Protter, Jing Ying Ma,
Ruban Mangadu, Ramona Almirez,
Bruce Koppelman, Irene Ken*,
Tony A. Navas, Fabiola Movius,
Mamalha Reddy, Yu-Wang Liu,
Gregory Luedtke, John Perumattam,
Babu Mavunkel, Sundeep Dugar, and
George F. Schreiner
Guohong Liu, Sarah Melissa P. Jacobo,
Nathan Hilliard, and Gregory H. Hockerman
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152
Rina Aharoni, Basak Kayhan, Ori Brenner,
Hagit Domcv, Galya Labunskay, and Ruth
Arnon
INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
(5ff)-5-Hydroxytriptolide Attenuated Collagen-Induced
Arthritis in DBA/1 Mice via Suppressing Interferon-y
Production and Its Related Signaling
Inhibition of Nuclear Factor-wE Enhances the Capacity of
Immature Dendritic Cells to Induce Antigen-Specific
Tolerance in Experimental Autoimmune Encephalomyelitis
Glycogen Synthase Kinase-30 Inhibition Reduces Secondary
Damage in Experimental Spinal Cord Trauma
A Selective p38(* Mitogen-Activated Protein Kinase Inhibitor
Reverses Cartilage and Bone Destruction in Mice with
Collagen-Induced Arthritis
Ru Zhou, Wei Tang, Yong-Xin Ren,
Pei-Lan He, Fan Zhang, Li-Ping Shi, Yun-
Feng Fu, Yuan-Chao Li, Shiro Ono, Hiromi
Fujiwara, Yi-Fu Yang, and Jian-Ping Zuo
Mirentxu I. Iruretagoyena,
Soffa H. Sepulveda, J. Pablo Lezana,
Marcela Hermoso, Miguel Bronfman,
Miguel A. Gutierrez, Sergio H. Jacobelli, and Alexis M. Kalergis
Salvatore Cuzzocrea, Tiziana Genovese,
Bmanuela Mazzon, Concetta Crisafulli,
Rosanna Di Paola, Carmelo Muia,
Marika Collin, Emanuela Esposito,
Placido Bramanti, and Christoph Thicmcrmann
Satyanarayana Medicherla, Jing Ying Ma,
Ruban Mangadu, Yebin Jiang,
Jenny J. Zhao, Ramona Almirez, Trene Kcrr,
Elizabeth G. Stebbins, Gilbert O'Young,
Ann M. Kapoun, Gregory Lucdtkc,
Sarvajit Chakravarty, Sundeep Dugar,
Harry K. Gcnant, and Andrew A. Protter
Robert Fiirst, Signe B. Blumenthal,
Alexandra K. Kiemer, Stefan Zahler, and
Angelika M. Vollmar
Nuclear FactorK B-Independent Anti-Inflammatory Action of
Salicylate in Human Endothelial Cells: Induction of Heme
Oxygenase-1 by the c-Jun N-Terminal Kinase/Activator
Protein-1 Pathway
Selective Inhibition of Eosinophil Influx into the Lung by
Small Molecule CC Chemokine Receptor 3 Antagonists in
Mouse Models of Allergic Inflammation
Anuk M. Das, Krishna G. Vaddi,
Kimberly A. Solomon, Candice Krauthauser,
Xiaosui Jiang, Kim W. Mclntyre,
Xiao Xia Yang, Eric Wadman,
Patricia Welch, Maryannc Covington,
Danielle Graden, Krishnaswamy Yeleswaram,
James M. Trzaskos, Robert C. Newton,
Sandhya Mandlekar, Soo S. Ko,
Percy H. Carter, and Paul Davies
METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
Carcinogen and Anticancer Drug Transport by Mrp2 in Vivo:
Studies Using Mrp2 (Abccl) Knockout Mice
Metabolism of Efavirenz and 8-Hydroxyefavirenz by P450 2B6
Leads to Inactivation by Two Distinct Mechanisms
Vectorial Transport of Enalapril by Oatplal/Mrp2 and
OATP1B1 and OATP1B3/MRP2 in Rat and Human Livers
M. L. H. Vlaming, K. Mohrmann,
E. Wagenaar, D. R. de Waart,
R. P. J. Oude Elferink, J. S. Lagas,
O. van Tellingen, L. D. Vainchtein,
H. Rosing, J. H. Beijnen, J. H. M. Schellens, and A. H. Schinkcl
Namandje N. Bumpus, Ute M. Kent, and
Paul F. Hollcnbcrg
Lichuan Liu, Yunhai Cui, Alfred Y. Chung,
Yoshihisa Shitara, Yuichi Sugiyama,
Dietrich Keppler, and K. Sandy Pang
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395

Paclitaxel and Docetaxel Stimulation of Doxorubicinol
Formation in the Human Heart: Implications for
Cardiotoxicity of Doxorubicin-Taxane Chemotherapies
Transport Characteristics of a Novel Peptide Transporter 1
Substrate, Antihypotensive Drug Midodrine, and Its Amino
Acid Derivatives
NEUROPHARMACOLOGY
Physiological and Biophysical Factors That Influence
Alzheimer's Disease Amyloid Plaque Targeting of Native and
Putrescine Modified Human Amyloid 040
Emanuela Salvatorelli, Pierantonio Menna,
Sabrina Cascegna, Giovanni Liberi,
Antonio M. Calafiore, Luca Gianni, and
Giorgio Minotti
Masahiro Tsuda, Tomohiro Terada,
Megumi Me, Toshiya Katsura,
Ayumu Niida, Kenji Tomita,
Nobutaka Fujii, and Ken-ichi Inui
Interaction of Functionalized Superparamagnetic Iron Oxide
Nanoparticles with Brain Structures
Biphenyl-indanone A, a Positive Allosteric Modulator of the
Metabotropic Glutamate Receptor Subtype 2, Has
Antipsychotic- and Anxiolytic-Like Effects in Mice
Buprenorphine Activates fx and Opioid Receptor Like-1
Receptors Simultaneously, but the Analgesic Effect Is Mainly
Mediated by /i Receptor Activation in the Rat Formalin Test
Specific Plasma Membrane Binding Sites for Polyphenols,
Including Resveratrol, in the Rat Brain
Thienorphine Is a Potent Long-Acting Partial Opioid Agonist:
A Comparative Study with Buprenorphine
Pharmacological Evaluation of Cannabinoid Receptor Ligands in a Mouse Model of Anxiety: Further Evidence for an
Anxiolytic Role for Endogenous Cannabinoid Signaling
Differential Regulation of Mesolimbic a3*/a6/32* and a4/J2*
Nicotinic Acetylcholine Receptor Sites and Function after
Long-Term Oral Nicotine to Monkeys
Effects of Anesthetics on Mutant A'-Methyl-D-Aspartate
Receptors Expressed in Xenopus Oocytes
TOXICOLOGY
Enhanced Xenobiotic-Induced Hepatotoxicity and Kupffer Cell
Activation by Restraint-Induced Stress
Nitroglycerin Attenuates Human Endothelial Progenitor Cell
Differentiation, Function, and Survival
Paradoxical Effects of Hydrogen Peroxide on Human Airway
Anion Secretion
Bioactive Properties of Iron-Containing Carbon Monoxide-
Releasing Molecules
The Anti-Inflammatory Drug, Nimesulide (4-Nitro-2phenoxymethane-sulfoanilide), Uncouples Mitochondria and
Induces Mitochondrial Permeability Transition in Human
Hepatoma Cells: Protection by Albumin
Karunya K. Kandimalla, Geoffry L. Curran,
Silvina S. Holasek, Emily J. Gilles,
Thomas M. Wengenack, Marina
Ramirez-Alvarado, and Joseph F.
Poduslo
Feride Cengelli, Dusica Maysinger,
Florianne Tschudi-Monnet, Xavier Montet, Claire
Corot, Alke Petri-Fink, Heinrich Hoi'mann, and
Lucienne Juillerat-Jeanneret
Ruggero Galici, Carrie K. Jones,
Kamondanai Hemstapat, Yi Nong, Nicholas
G. Echemendia, Liliy C. Williams, Tomas de
Paulis, and P. Jeffrey Conn
Tatsuo Yamamoto, Koyo Shono, and
Serabi Tanabe
Ying-Shan Han, Stephane Bastianetto,
Yvan Dumont, and Remi Quirion
Gang Yu, Yong-Juan Yue, Meng-Xun Cui, and Ze-Hui Gong
Sachin Patcl and Cecilia J. Hillard
Sarah E. McCallum, Neeraja Parameswaran,
Tanuja Bordia, Hong Fan,
J. Michael Mclntosh, and Maryka Quik
Junichi Ogata, Munehiro Shiraishi,
Tsunehisa Namba, C. Thetford Smothers,
John J. Woodward, and R. Adron Harris
Sree D. Panuganti, Farah D. Khan, and
Craig K. Svensson
Jonathan M. DiFabio, George R. Thomas,
Liana Zucco, Michael A. Kuliszewski, Brian
M. Bennett, Michael J. Kutryk, and John D.
Parker
Takamasa Ohashi, Yasushi Ito,
Tadakatsu Matsuno, Shinji Sato, Kaoru
Shimokata, and Hiroaki Kume
Philip Sawle, Jehad Hammad,
Ian J. S. Fairlamb, Benjamin Moulton,
Ciara T. O'Brien, Jason M. Lynam,
Anne K. Duhme-Klair, Roberta Foresti, and
Roberto Motterlini
Alain Berson, Sophie Cazanave,
Veronique Descatoire, Marina Tinel,
Alain Grodet, Claude Wolf,
Gerard Feldmann, and Dominique Pessayre
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