318_01_2006

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The Journal of

PHARMACOLOGY

And Experimental Therapeutics

A Publication of the American Society for Pharmacology and Experimental Therapeutics

July 2006 Vol. 318,

No. 1

Contents

PERSPECTIVES IN PHARMACOLOGY

Alcohol Use, Vascular Disease, and Lipid-Lowering Drugs

Genovefa

D. Kolovou, Klelia D. Salpea,

Katherine K. Anagnostopoulou, and

Dimitri P. Mikhailidis

BEHAVIORAL PHARMACOLOGY

Antinociceptive Pharmacology of iV-[[4-(4,5-Dihydro-lffimidazol-2-yl)phenyl]methyl]-2-[2-[[(4-methoxy-2,6dimethylphenyl) sulfonyl]methylamino]ethoxy]-A'methylacetamide, Fumarate (LF22-0542), a Novel Nonpeptidic

Bradykinin B, Receptor Antagonist

Relative Reinforcing Effects of Cocaine, Remifentanil, and

Their Combination in Rhesus Monkeys

Endogenous Orphanin FQ/Nociceptin Is Involved in the

Development of Morphine Tolerance

CARDIOVASCULAR

Induction of Heme Oxygenase-1 Is Involved in Carbon

Monoxide-Mediated Central Cardiovascular Regulation

Pleiotropic Effects of the J3-Adrenoceptor Blocker Carvedilol on Calcium Regulation during Oxidative Stress-Induced

Apoptosis in Cardiomyocytes

Role of Phosphorus and Vitamin D Analogs in the

Pathogenesis of Vascular Calcification

F. Porreca, T.

W. Vanderah,

W.

Guo,

M.

Barth, P. Dodey, V. Peyrou,

J. M. Luccarini, J.-L. Junien, and D. Pruneau

G. Winger, C. M. Galuska, S. R. Hursh, and

J. H. Woods

Shinjae Chung, Sigrun Pohl, Joanne Zeng,

Olivier

Civelli,

and Rainer K. Reinscheid

195

223

262

Wan-Chen Lo, Pei-Jung Lu, Wen-Yu Ho, 8

Michael Hsiao, and Ching-Jiunn Tseng

45 Ruijuan Wang, Toshiro Miura,

Nozomu

Harada, Ryosuke Kametani,

Masaki Shibuya, Yasuhiro Fukagawa, Shuji

Kawamura, Yasuhiro Ikeda, Masayuki Hara, and Masunori Matsuzaki

90 J. Ruth Wu-Wong, William Noonan,

Junli Ma, Doug Dixon, Masaki Nakane,

Antoinette L. Bolin, Kristin A. Koch, Steve

Postl, Sherry J. Morgan, and Glenn A.

Reinhart

Sung-Sik Park, Hong Zhao, Yeongho Jang,

Robert A. Mueller, and Zhelong Xu

124

A^-(3-Iodobenzyl)-adenosine-5'-iV-niethylcarboxamide Confers

Cardioprotection at Reperfusion by Inhibiting Mitochondrial

Permeability Transition Pore Opening via Glycogen Synthase

Kinase 3/3

Volatile Anesthetic Preconditioning Attenuates Myocardial

Apoptosis in Rabbits after Regional Ischemia and Reperfusion via Akt Signaling and Modulation of Bcl-2 Family Proteins

Blocking Late Sodium Current Reduces Hydrogen Peroxide-

Induced Arrhythmogenic Activity and Contractile Dysfunction

Jacob Raphael, Suzan Abedat, Julia Rivo,

Karen Meir, Ronen Been, Thea Pugatsch,

Zhiyi Zuo, and Yaacov Gozal

Yejia Song, John C.

Shryocfc,

Stefan Wagner, Lars S. Maier, and

Luiz Belardinelli

186

214

Central Adenosine Signaling Plays a Key Role in Centrally

Mediated Hypotension in Conscious Aortic Barodenervated Rats

Augmented Endothelium-Derived Hyperpolarizing Factor-

Mediated Relaxations Attenuate Endothelial Dysfunction in

Femoral and Mesenteric, but Not in Carotid Arteries from

Type r Diabetic Rats

Increased RhoA/Rho-Kinase Signaling Mediates Spontaneous

Tone in Aorta from Angiotcnsin II-Induced Hypertensive Rats

Synthetic Peroxisome Proliferator-Activated Receptor-y

Agonists Restore Impaired Vasorelaxation via ATP-Sensitive

K

+

Channels by High Glucose

Sesamin Metabolites Induce an Endothclial Nitric Oxide-

Dependent Vasorelaxation through Their Antioxidative

Property-Independent Mechanisms: Possible Involvement of the Metabolites in the Antihypertensive Effect of Sesamin

The Emerging Cardioinhibitory Role of the Hippocampal

Cholinergic Neurostimulating Peptide

Differentiation of Arrhythmia Risk of the Antibacterials

Moxifloxacin, Erythromycin, and Telithromycin Based on

Analysis of Monophasic Action Potential Duration Alternans and Cardiac Instability

Improved Left Ventricular Function and Reduced Necrosis after Myocardial Ischemia/Reperfusion in Rabbits Treated with Ranolazine, an Inhibitor of the Late Sodium Channel

CELLULAR AND MOLECULAR p53 Suppression of Arsenite-Induced Mitotic Catastrophe Is

Mediated by p

21

CIP1/WAF1

Noha Nassar and Abdel A. Abdel-Rahman

Yi Shi, David D. Ku, Ricky Y. K. Man, and

Paul M. Vanhoutte

Liming Jin, Zhekang Ying,

Rob H. P. Hilgers,

Jia

Yin, Xueying Zhao,

John D. Imig, and R. Clinton Webb

Hiroyuki Kinoshita, Toshiharu Azma,

Hiroshi

tranami, Katsutoshi

Nakahata,

Yoshiki Kimoto, Mayuko Dojo,

Osafumi

Yuge, and Yoshio Hatano

Daisuke Nakano, Chol-Jun Kwak, Kiwako

Fujii, Kenjj Ikemura, Aiko Satakc, Mamoru

Ohkita, Masanori Takaoka, Yoshiko Ono,

Masaaki Nakai. Namino

Tomimori,

Yoshinobu Kiso, and Yasuo

Matsumura

Tommaso

Angelone, Yannick

Goumon,

Maria Carmela Cerra, Marie-Helene Metz-

Boutiguc, Dominique Aunis, and Bruno Tota

Todd Wisialowski. Kimbcrly Criinin,

Juntyma Engtrakul, John O'Donnell,

Bernard Fermini, and Anthony A. Fossa

Sharon L, Hale, Justin A. Lceka, and

Robert A, Kloncr

Augmentation of Ca v

3.2 T-Type Calcium Channel Activity by cAMP-Dependent Protein Kinase A

Subtype-Specific Inhibition of Nicotinic Acetylcholine

Receptors by Choline: A Regulatory Pathway

Role of Phosphatidylinositol 3-Kinase/AKT as a Survival

Pathway against CYP2K1 -Dependent Toxicity

Protein Kinase C5 Mediates Platelet-Induced Breast Cancer

Cell Invasion

B. Frazier Taylor, Samuel C. McNeely,

Heather L. Miller, Geniece M. Lchmann,

Michael J. McCabe, Jr., and J. Christopher

States

Jin-Ah

Kim, Jin-Yong

Park, Ho-Won Kang,

Sung-Un Huh, Seong-Woo Jeong, and

Jung-

Ha

Lee

Manickavasagom Alkondon and

Edson X. Albuquerque

Andres A. Caro and Arthur I. Cederbaum

David Alonso-Escolano, Carlos Medina,

Katarzyna Cieslik, Anna Radomski, Paul

Jurasz,

Maria Jose Santos-Martinez, Tilahum

Jiffar. Peter Ruvolo, and Marek W.

Radomski

CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY

Inhibition of Protein Kinase c-Src Reduces the Incidence of

Breast Cancer Metastases and Increases Survival in Mice:

Implications for Therapy

Blockade of Angiogenesis by Small Molecule Antagonists to

Protease-Activated Receptor-1: Association with Endothelial

Cell Growth Suppression and Induction of Apoptosis

Nadia Rucci, Irene Recchia,

Adriano Angelucci, Marina Alamanou,

Andrea Del Faitore, Dario Fortunati,

Mira Susa,

Doriano

Fabbro, Mauro Bologna, and Anna Teti

Panagiota Zania, Sosanna Kritikou,

Christodoulos S. Flordellis, Michael

E. Maragoudakis, and Nikos E.

Tsopanoglou

ENDOCRINE AND DIABETES

Cilostazol Protects Diabetic Rats from Vascular Inflammation via Nuclear Factor-KB-Dependent Down-Regulation of

Vascular Cell Adhesion Molecule-1 Expression

Ling

Gao,

Jiajun Zhao

Furong Wang, Bo Wang,

Bendi Gong, Jie Zhang, Xiumei Zhang, and

255

276

288

312

328

336

352

418

142

161

246

53

230

268

360

373

Preventive and Therapeutic Potential of p38«-Selective

Mitogen-Activated Protein Kinase inhibitor in Nonobese

Diabetic Mice with Type 1 Diabetes

Differential Modulation of Ca v

1.2 and Ca v

1.3-Mediated

Glucose-Stimulated Insulin Secretion by cAMP in INS-1 Cells:

Distinct Roles for Exchange Protein Directly Activated by cAMP 2 (Epac2) and Protein Kinase A

GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL

Iinmunomodulatory Therapeutic Effect of Glatiramer Acetate on Several Murine Models of Inflammatory Bowel Disease

Salyanarayana Medicherla,

Andrew A. Protter, Jing Ying Ma,

Ruban Mangadu, Ramona Almirez,

Bruce Koppelman, Irene Ken*,

Tony A. Navas, Fabiola Movius,

Mamalha Reddy, Yu-Wang

Liu,

Gregory Luedtke, John Perumattam,

Babu Mavunkel, Sundeep Dugar, and

George F. Schreiner

Guohong Liu, Sarah Melissa P. Jacobo,

Nathan Hilliard, and Gregory H. Hockerman

99

152

Rina Aharoni, Basak Kayhan, Ori Brenner,

Hagit Domcv, Galya Labunskay, and Ruth

Arnon

INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA

(5ff)-5-Hydroxytriptolide Attenuated Collagen-Induced

Arthritis in DBA/1 Mice via Suppressing Interferon-y

Production and Its Related Signaling

Inhibition of Nuclear Factor-wE Enhances the Capacity of

Immature Dendritic Cells to Induce Antigen-Specific

Tolerance in Experimental Autoimmune Encephalomyelitis

Glycogen Synthase Kinase-30 Inhibition Reduces Secondary

Damage in Experimental Spinal Cord Trauma

A Selective p38(* Mitogen-Activated Protein Kinase Inhibitor

Reverses Cartilage and Bone Destruction in Mice with

Collagen-Induced Arthritis

Ru Zhou, Wei Tang, Yong-Xin Ren,

Pei-Lan He, Fan Zhang, Li-Ping Shi, Yun-

Feng Fu, Yuan-Chao Li, Shiro Ono, Hiromi

Fujiwara, Yi-Fu Yang, and Jian-Ping Zuo

Mirentxu I. Iruretagoyena,

Soffa

H. Sepulveda, J. Pablo Lezana,

Marcela Hermoso, Miguel Bronfman,

Miguel A. Gutierrez, Sergio H. Jacobelli, and Alexis M. Kalergis

Salvatore Cuzzocrea, Tiziana Genovese,

Bmanuela Mazzon, Concetta Crisafulli,

Rosanna Di Paola, Carmelo Muia,

Marika Collin, Emanuela Esposito,

Placido Bramanti, and Christoph Thicmcrmann

Satyanarayana Medicherla, Jing Ying Ma,

Ruban Mangadu, Yebin Jiang,

Jenny J. Zhao, Ramona Almirez, Trene Kcrr,

Elizabeth G. Stebbins, Gilbert O'Young,

Ann M. Kapoun, Gregory Lucdtkc,

Sarvajit Chakravarty, Sundeep Dugar,

Harry K. Gcnant, and Andrew A. Protter

Robert Fiirst, Signe B. Blumenthal,

Alexandra K. Kiemer, Stefan Zahler, and

Angelika M. Vollmar

Nuclear Factor-

K

B-Independent Anti-Inflammatory Action of

Salicylate in Human Endothelial Cells: Induction of Heme

Oxygenase-1 by the c-Jun N-Terminal Kinase/Activator

Protein-1 Pathway

Selective Inhibition of Eosinophil Influx into the Lung by

Small Molecule CC Chemokine Receptor 3 Antagonists in

Mouse Models of Allergic Inflammation

Anuk M. Das, Krishna G. Vaddi,

Kimberly A. Solomon, Candice Krauthauser,

Xiaosui Jiang, Kim W. Mclntyre,

Xiao Xia Yang, Eric Wadman,

Patricia Welch, Maryannc Covington,

Danielle Graden, Krishnaswamy Yeleswaram,

James M. Trzaskos, Robert C. Newton,

Sandhya Mandlekar, Soo S. Ko,

Percy H. Carter, and Paul Davies

METABOLISM, TRANSPORT, AND PHARMACOGENOMICS

Carcinogen and Anticancer Drug Transport by Mrp2 in Vivo:

Studies Using Mrp2 (Abccl) Knockout Mice

Metabolism of Efavirenz and 8-Hydroxyefavirenz by P450 2B6

Leads to Inactivation by Two Distinct Mechanisms

Vectorial Transport of Enalapril by Oatplal/Mrp2 and

OATP1B1 and OATP1B3/MRP2 in Rat and Human Livers

M. L. H. Vlaming, K. Mohrmann,

E. Wagenaar, D. R. de Waart,

R. P. J. Oude Elferink, J. S. Lagas,

O. van Tellingen, L. D. Vainchtein,

H. Rosing, J. H. Beijnen, J. H. M. Schellens, and A. H. Schinkcl

Namandje N. Bumpus, Ute M. Kent, and

Paul F. Hollcnbcrg

Lichuan Liu, Yunhai Cui, Alfred Y. Chung,

Yoshihisa Shitara, Yuichi Sugiyama,

Dietrich Keppler, and K. Sandy Pang

35

59

79

132

389

411

319

345

395

Paclitaxel and Docetaxel Stimulation of Doxorubicinol

Formation in the Human Heart: Implications for

Cardiotoxicity of Doxorubicin-Taxane Chemotherapies

Transport Characteristics of a Novel Peptide Transporter 1

Substrate, Antihypotensive Drug Midodrine, and Its Amino

Acid Derivatives

NEUROPHARMACOLOGY

Physiological and Biophysical Factors That Influence

Alzheimer's Disease Amyloid Plaque Targeting of Native and

Putrescine Modified Human Amyloid 040

Emanuela Salvatorelli, Pierantonio Menna,

Sabrina Cascegna, Giovanni Liberi,

Antonio M. Calafiore, Luca Gianni, and

Giorgio Minotti

Masahiro Tsuda, Tomohiro Terada,

Megumi Me, Toshiya Katsura,

Ayumu Niida, Kenji Tomita,

Nobutaka Fujii, and Ken-ichi Inui

Interaction of Functionalized Superparamagnetic Iron Oxide

Nanoparticles with Brain Structures

Biphenyl-indanone A, a Positive Allosteric Modulator of the

Metabotropic Glutamate Receptor Subtype 2, Has

Antipsychotic- and Anxiolytic-Like Effects in Mice

Buprenorphine Activates fx and Opioid Receptor Like-1

Receptors Simultaneously, but the Analgesic Effect Is Mainly

Mediated by /i Receptor Activation in the Rat Formalin Test

Specific Plasma Membrane Binding Sites for Polyphenols,

Including Resveratrol, in the Rat Brain

Thienorphine Is a Potent Long-Acting Partial Opioid Agonist:

A Comparative Study with Buprenorphine

Pharmacological Evaluation of Cannabinoid Receptor Ligands in a Mouse Model of Anxiety: Further Evidence for an

Anxiolytic Role for Endogenous Cannabinoid Signaling

Differential Regulation of Mesolimbic a3*/a6/32* and a4/J2*

Nicotinic Acetylcholine Receptor Sites and Function after

Long-Term Oral Nicotine to Monkeys

Effects of Anesthetics on Mutant A'-Methyl-D-Aspartate

Receptors Expressed in Xenopus Oocytes

TOXICOLOGY

Enhanced Xenobiotic-Induced Hepatotoxicity and Kupffer Cell

Activation by Restraint-Induced Stress

Nitroglycerin Attenuates Human Endothelial Progenitor Cell

Differentiation, Function, and Survival

Paradoxical Effects of Hydrogen Peroxide on Human Airway

Anion Secretion

Bioactive Properties of Iron-Containing Carbon Monoxide-

Releasing Molecules

The Anti-Inflammatory Drug, Nimesulide (4-Nitro-2phenoxymethane-sulfoanilide), Uncouples Mitochondria and

Induces Mitochondrial Permeability Transition in Human

Hepatoma Cells: Protection by Albumin

Karunya K. Kandimalla, Geoffry L. Curran,

Silvina S. Holasek, Emily J. Gilles,

Thomas M. Wengenack, Marina

Ramirez-Alvarado, and Joseph F.

Poduslo

Feride Cengelli, Dusica

Maysinger,

Florianne Tschudi-Monnet, Xavier Montet, Claire

Corot, Alke Petri-Fink, Heinrich Hoi'mann, and

Lucienne Juillerat-Jeanneret

Ruggero

Galici, Carrie K. Jones,

Kamondanai Hemstapat, Yi

Nong,

Nicholas

G. Echemendia, Liliy C. Williams, Tomas de

Paulis,

and P. Jeffrey Conn

Tatsuo Yamamoto, Koyo Shono, and

Serabi Tanabe

Ying-Shan Han, Stephane Bastianetto,

Yvan Dumont, and Remi Quirion

Gang Yu, Yong-Juan Yue, Meng-Xun Cui, and Ze-Hui Gong

Sachin

Patcl and Cecilia J. Hillard

Sarah E. McCallum, Neeraja Parameswaran,

Tanuja Bordia, Hong Fan,

J. Michael Mclntosh, and Maryka Quik

Junichi Ogata, Munehiro Shiraishi,

Tsunehisa Namba, C.

Thetford

Smothers,

John J. Woodward, and R. Adron Harris

Sree D. Panuganti, Farah D. Khan, and

Craig K. Svensson

Jonathan M. DiFabio, George R. Thomas,

Liana Zucco, Michael A. Kuliszewski, Brian

M. Bennett, Michael J. Kutryk, and John D.

Parker

Takamasa Ohashi, Yasushi Ito,

Tadakatsu Matsuno, Shinji Sato, Kaoru

Shimokata, and Hiroaki Kume

Philip Sawle, Jehad Hammad,

Ian J. S. Fairlamb, Benjamin Moulton,

Ciara T. O'Brien, Jason M. Lynam,

Anne K. Duhme-Klair, Roberta Foresti, and

Roberto Motterlini

Alain Berson, Sophie Cazanave,

Veronique Descatoire, Marina Tinel,

Alain Grodet, Claude Wolf,

Gerard Feldmann, and Dominique Pessayre

424

455

17

108

173

206

381

434

26

117

296

403

444

238

282

304

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