The Journal of
PHARMACOLOGY
And Experimental Therapeutics
A Publication of the American Society for Pharmacology and Experimental Therapeutics
July 2008
Vol. 325, No. 3
Contents
PERSPECTIVES IN PHARMACOLOGY
The Ambiguities of Opioid Tolerance Mechanisms: Barriers to
Pain Therapeutics or New Pain Therapeutic Possibilities
Alan R. Gintzler and Sumita Chakrabarti
709
BEHAVIORAL PHARMACOLOGY
Effects of Spinal a2-Adrenoceptor and Ij-Imidazoline
Receptor Activation on Hindlimb Movement Induction in
Spinal Cord-Injured Mice
Nicolas P. Lapointe, Roth-Visal Ung,
Pascal Rouleau, and Pierre A. Guertin
994
A. Elizabeth Linder, Wei Ni, Theodora
Szasz, Robert Burnett, Jessica Diaz,
Timothy J. Geddes, Donald M. Kuhn, and
Stephanie W. Watts
714
The T- and L-Type Calcium Channel Blocker (CCB)
Mibefradil Attenuates Leg Edema Induced by the L-Type CCB
Nifedipine in the Spontaneously Hypertensive Rat: A Novel
Differentiating Assay
Terry C. Major, Shantanu Dhamija,
Nicole Black, Serguei Liachenko,
Brandy Morenko, Gregg Sobocinski,
Carlin Okerberg, Paula Tinholt,
Steven Madore, and Mark C. Kowala
723
Long-Term but Not Short-Term p38 Mitogen-Activated
Protein Kinase Inhibition Improves Cardiac Function and
Reduces Cardiac Remodeling Post-Myocardial Infarction
A. R. Kompa, F. See, D. A. Lewis,
A. Adrahtas, D. M. Cantwell, B. H. Wang,
and H. Krum
741
Interdependent Regulation of Afferent Renal Nerve Activity
and Renal Function: Role of Transient Receptor Potential
Vanilloid Type 1, Neurokinin 1, and Calcitonin Gene-Related
Peptide Receptors
Chaoqin Xie, Jeffrey R. Sachs, and
Donna H. Wang
751
Combination of the Angiotensin-Converting Enzyme Inhibitor
Perindopril and the Diuretic Indapamide Activate Postnatal
Vasculogenesis in Spontaneously Hypertensive Rats
Dong You, Clement Cochain, Celine
Loinard, Jose Vilar, Barend Mees,
Micheline Duriez, Bernard I. Levy, and
Jean-Sebastien Silvestre
766
Mitochondrial Effects of Estrogen Are Mediated by Estrogen
Receptor a in Brain Endothelial Cells
Ali Razmara, Lorraine Sunday, Chris
Stirone, Xiao Bo Wang, Diana N. Krause,
Sue P. Duckies, and Vincent Procaccio
782
CARDIOVASCULAR
A Serotonergic System in Veins: Serotonin TransporterIndependent Uptake
Nebivolol, but Not Metoprolol, Improves Endothelial Function
of the Corpus Cavernosum in Apolipoprotein E-Knockout
Mice
Magnus Baumhakel, Nils Schlimmer,
Kansu Biiyiikafgar, Onur Arikan, and
Michael Bohm
818
Differential Effect of the Protein Synthesis Inhibitors
Puromycin and Cycloheximide on Vascular Smooth Muscle
Cell Viability
Valerie Croons, Wim Martinet,
Arnold G. Herman, and
Guido R. Y. De Meyer
824
Heme Oxygenase-Mediated Increases in Adiponectin Decrease
Fat Content and Inflammatory Cytokines Tumor Necrosis
Factor-a and Interleukin-6 in Zucker Rats and Reduce
Adipogenesis in Human Mesenchymal Stem Cells
Dong Hyun Kim, Angela P. Burgess,
Ming Li, Peter L. Tsenovoy, Francesco
Addabbo, John A. McClung, Nitin Puri, and
Nader G. Abraham
833
Antitorsadogenic Effects of (±)-iV-(2,6-Dimethyl-phenyl)-(4[2hydroxy-3-(2-methoxyphenoxy)propyl]-l-piperazine
(Ranolazine) in Anesthetized Rabbits
Wei-Qun Wang, Chelsea Robertson,
Arvinder K, Dhalla, and Luiz Belardinelli
875
Female Rats Fed a High-Fat Diet Were Associated with
Vascular Dysfunction and Cardiac Fibrosis in the Absence of
Overt Obesity and Hyperlipidemia: Therapeutic Potential of
Resveratrol
Marie-Claude Aubin, Claude Lajoie,
Robert Clement, Hugues Gosselin, Angelino
Calderone, and Louis P. Perrault
961
5-Hydroxytryptamine Lowers Blood Pressure in Normotensive
and Hypertensive Rats
Jessica Diaz, Wei Ni, Janice Thompson,
Andrew King, Gregory D. Fink, and
Stephanie W. Watts
CELLULAR AND MOLECULAR
Extracellular Signal-Regulated Kinase Activation Mediates
Mitochondrial Dysfunction and Necrosis Induced by
Hydrogen Peroxide in Renal Proximal Tubular Cells
1031
Shougang Zhuang, Gilbert R. Kinsey,
Yan Yan, Jiahuai Han, and
Rick G. Schnellmann
732
[s] MSFTZ, a Flavanone Derivative, Induces Human Hepatoma
Cell Apoptosis via a Reactive Oxygen Species- and CaspaseDependent Mitochondrial Pathway
Lysophosphatidic Acid Induces Rapid and Sustained
Decreases in Epidermal Growth Factor Receptor Binding via
Different Signaling Pathways in BEAS-2B Airway Epithelial
Cells
Meidan Ying, Chongxing Tu, Huazhou Ying,
Yongzhou Hu, Qiaojun He, and Bo Yang
758
Karen M. Kassel, Puttappa R. Dodmane,
Nancy A. Schulte, and Myron L, Toews
809
BO Synthesis and Characterization of 125I-a-Conotoxin
ArIB[VllL;V16A], a Selective oH Nicotinic Acetylcholine
Receptor Antagonist
Paul Whiteaker, Michael J. Marks,
Sean Christensen, Cheryl Dowell,
Allan C. Collins, and J. Michael Mclntosh
910
The Impact of Orthosteric Radioligand Depletion on the
Quantification of Allosteric Modulator Interactions
Vimesh A. Avlani, David J. McLoughlin,
Patrick M. Sexton, and Arthur Christopoulos
927
Muscarinic M4 Receptor Recycling Requires a Motif in the
Third Intracellular Loop
Yuichi Hashimoto, Kanoko Morisawa,
Hiroyuki Saito, Eri Jojima, Norihiro
Yoshida, and Tatsuya Haga
947
Plant-Derived Cannabinoids Modulate the Activity of
Transient Receptor Potential Channels of Ankyrin Type-1 and
Melastatin Type-8
Luciano De Petrocellis, Vittorio Vellani,
Aniello Schiano-Moriello, Pietro Marini, Pier
Cosimo Magherini, Pierangelo Orlando, and
Vincenzo Di Marzo
1007
Parallel Improvement of Sodium and Chloride Transport
Defects by Miglustat (n-Butyldeoxynojyrimicin) in Cystic
Fibrosis Epithelial Cells
Cysteinyl Leukotriene-1 Receptor Activation in a Human
Bronchial Epithelial Cell Line Leads to Signal Transducer and
Activator of Transcription 1-Mediated Eosinophil Adhesion
Sabrina Noel, Martina Wilke,
Alice G. M. Bot, Hugo R. De Jonge, and
Frederic Becq
1016
Mirella Profita, Angelo Sala, Anna Bonanno,
Liboria Siena, Maria Ferraro,
Rossana Di Giorgi, Angela M. Montalbano,
Giusy D. Aibano, Rosalia Gagliardo, and
Mark Gjomarkaj
1024
Frederick J. Ehlert and Michael T. Griffin
1039
Two-State Models and the Analysis of the Allosteric Effect of
Gallamine at the M 2 Muscarinic Receptor
CHEMOTHERAPY, ANTIBIOTICS, AND GENE THERAPY
Protoapigenone, a Novel Flavonoid, Induces Apoptosis in
Human Prostate Cancer Cells through Activation of p38
Mitogen-Activated Protein Kinase and c-Jun NH2-Terminal
Kinase 1/2
GASTROINTESTINAL, HEPATIC, PULMONARY, AND RENAL
New Role of Resistin in Lipopolysaccharide-Induced Liver
Damage in Mice
Hsueh-Ling Chang, Yang-Chang Wu,
Jinu-Huang Su, Yao-Tsung Yeh, and
Shyng-Shiou F. Yuan
841
Juliane I. Beier, Luping Guo,
Claudia von Montfort, J. Phillip Kaiser,
Swati Joshi-Barve, and Gavin E. Arteel
801
Assessment of Nerve Stimulation-Induced Release of Purines
from Mouse Kidneys by Tandem Mass Spectrometry
Jin Ren, Zaichuan Mi, and
Edwin K. Jackson
920
The Use of Occupation Isoboles for Analysis of a Response
Mediated by Two Receptors: M2 and 3VI3 Muscarinic Receptor
Subtype-Induced Mouse Stomach Contractions
Induction of Apoptosis in Renal Tubular Cells by Histone
Deacetylase Inhibitors, a Family of Anticancer Agents
Alan S. Braverman, Ronald J. Tallarida, and
Michael R. Ruggieri, Sr.
954
INFLAMMATION, IMMUNOPHARMACOLOGY, AND ASTHMA
Interleukin-13 Neutralization by Two Distinct Receptor
Blocking Mechanisms Reduces Immunoglobulin E Responses
and Lung Inflammation in Cynomolgus Monkeys
Guie Dong, Lysa Wang, Cong-Yi Wang,
Tianxin Yang, M. Vijay Kumar, and
Zheng Dong
Marion T. Kasaian, Xiang-Yang Tan,
Macy Jin, Lori Fitz, Kimberly Marquette,
Nancy Wood, Timothy A. Cook, Julie Lee,
Angela Widom, Rita Agostinelli,
Andrea Bree, Franklin J. Schlerman,
Stephane Olland, Michael Wadanoli,
Joseph Sypek, Davinder Gill,
Samuel J. Goldman, and
Lioudmila Tchistiakova
882
Nada Abla, Leslie W. Chinn,
Tsutomu Nakamura, Li Liu,
Conrad C. Huang, Susan J. Johns,
Michiko Kawamoto, Doug Stryke,
Travis R. Taylor, Thomas E. Ferrin,
Kathleen M. Giacomini, and
Deanna L. Kroetz
859
Cuyue Tang, Brian A. Carr,
Frederic Poignant, Bennett Ma,
Stacey L. Polsky-Fisher, Yuhsin Kuo,
Kristie Strong-Basalyga, Alisha Norcross,
Karen Richards, Roy Eisenhandler,
Edward J. Carlini, Christina Ng Di Marco,
Scott D. Kuduk, Nathan X. Yu,
Conrad E. Raab, Tom Rushmore,
Clay B. Frederick, Mark G. Bock, and
Thomayant Prueksaritanont
935
Shuji Maruyama, Hideo Tsukada,
Shingo Nishiyama, Takeharu Kakiuchi,
Dai Fukumoto, Naoto Oku, and Shizuo
Yamada
774
Comparative Molecular Field Analysis Using Selectivity Fields
Reveals Residues in the Third Transmembrane Helix of the
Serotonin Transporter Associated with Substrate and
Antagonist Recognition
Crystal C. Walline, David E. Nichols,
F. Ivy Carroll, and Eric L. Barker
79)
Cannabinoids Inhibit Network-Driven Synapse Loss between
Hippocampal Neurons in Culture
Hee Jung Kim, Jonathan J. Waataja, and
Stanley A. Thayer
850
Pharmacological Assessment of Ml Muscarinic Acetylcholine
Receptor-Gq/1I Protein Coupling in Membranes Prepared from
Postmortem Human Brain Tissue
Hasib Salah-Uddin, David R. Thomas,
Ceri H. Davies, Jim J. Hagan,
Martyn D. Wood, Jeannette M. Watson, and
R. A. John Challiss
869
Synthesis and Pharmacological in Vitro and in Vivo Profile of
3-Oxo-1,1 -diphenyl-tetrahy dro-oxazolo[3,4-o ]p yrazine-7carbosylic Acid 4-Fluoro-benzylamide (SHA 68), a Selective
Antagonist of the Neuropeptide S Receptor
Naoe Okamura, Stephen A. Habay,
Joanne Zeng, A. Richard Chamberlin, and Rainer
K. Reinscheid
893
Correlation between ex Vivo Receptor Occupancy and WakePromoting Activity of Selective H 3 Receptor Antagonists
Siyuan Le, John A. Gruner,
Joanne R. Mathiasen, Michael J. Marino, and
Herve Schaffhauser
902
Combined Active and Passive Immunization Enhances the
Efficacy of Immunotherapy against Nicotine in Rats
Samuel A. Roiko, Andrew C. Harris,
Daniel E. Keyler, Mark G. LeSage,
Yan Zhang, and Paul R. Pentel
985
METABOLISM, TRANSPORT, AND PHARMACOGENOMICS
The Human Multidrug Resistance Protein 4 (MRP4, ABCC4):
Functional Analysis of a Highly Polymorphic Gene
CYP2C75-Involved Autoinduction of Metabolism in Rhesus
Monkeys of Methyl 3-Chloro-3'-fluoro-4'-{(lfi)-l-[({l-[
(trifluoroacetyl)amino] cy clopr opyl} carbony l)amino]ethyl}-14rbiphenyl-2-carboxylate (MK-0686), a Bradykinin B, Receptor
Antagonist
NEUROPHARMACOLOGY
In Vivo Quantitative Autoradiographic Analysis of Brain
Muscarinic Receptor Occupancy by Antimuscarinic Agents for
Overactive Bladder Treatment
TOXICOLOGY
Dependence of Reactive Oxygen Species and FLICE
Inhibitory Protein on Lipofectamine-Induced Apoptosis in
Human Lung Epithelial Cells
ERRATA
Correction to "First in Vivo Evidence for a Functional
Interaction between Chemokine and Cannabinoid Systems in
the Brain"
Correction to "Tetrathiomolybdate Protects against Bile Duct
Ligation-Induced Cholestatic Liver Injury and Fibrosis"
Lalana Kongkaneramit, Narong Sarisuta,
Neelam Azad, Yongju Lu, Anand Krishnan
V. Iyer, Liying Wang, and Yon
Rojanasakul
969
1061
1062