Program Director/Principal Investigator (Last, First, Middle):
Nickells, Robert W.
For New and Renewal Applications (PHS 398) – DO NOT SUBMIT UNLESS REQUESTED
For Non-competing Progress Reports (PHS 2590) – Submit only Active Support for Key Personnel
PHS 398/2590 OTHER SUPPORT
Nickells, Robert W.
ACTIVE
P30 EY016665-01 (Brandt)
07/01/05-6/30/10
1.2 calendar
NIH/NEI
$388,000
Core Grant for Vision Research
This is a core facilities grant to the Department of Ophthalmology and Visual Sciences at the University of
Wisconsin. The CORE provides 1) Gene Therapy/Quantitative Molecular Biology, 2) Pathology and In vivo
Imaging, and 3) Animal and Eye Organ Culture. Dr. Nickells is the co-Director of the Molecular Biology
CORE.
R01 EY12223-08 (Nickells)
12/01/04-11/30/08
7.2 calendar
NIH/NEI
$305,000
The molecular mechanism of retinal ganglion cell death
The R29 grant of Dr. Nickells was converted to an R01 as a competitive renewal. This grant examines
further the role of Bax in ganglion cell death including susceptibility, regenerative capacity, and the
development of therapies designed to reduce Bax expression in wild type ganglion cells.
R03 EY016341-02 (Nickells)
NIH/NEI
04/01/06-03/31/08
1.2 calendar
No cost extension 03/31/09
$50,000
Mapping RGC death susceptibility alleles in mice
This application requests funds to map and characterize loci that segregate with ganglion cell resistance to
optic nerve crush.
G20007-063 (Nickells)
04/01/07-03/31/09
0.6 calendar
AHAF-National Glaucoma Research
$45,000
Cell based neurotrophin therapy for glaucoma
Assessment of efficacy of human neural progenitor cell transplants to provide neurotrophic support of
ganglion cells in a mouse model of glaucoma.
PENDING
R01 EY018869 (Nickells)
02/01/08-01/31/13
2.4 calendar
NIH/NEI
$270,156
Characterization of RGC death susceptibility alleles
This is an application to convert a current R03-funded project into an R01 to allow continued study of the
Rgcs1 locus in mice with emphasis on its role in modulating ganglion cell death in glaucoma.
R21 EY019554 (Nickells)
02/01/09-01/31/11
1.2 calendar
NIH/NEI
$125,000
Characterization of macroglial/retinal ganglion cell interactions
This application requests funds to explore the stimulatory and growth permissive functions of microglia on
axonal growth from retinal ganglion cells.
OVERLAP
None of these projects overlap.
PHS 398/2590 (Rev. 11/07)
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Program Director/Principal Investigator (Last, First, Middle):
Nickells, Robert W.
Schlamp, Cassandra L.
NONE
Yandell, Brian S.
ACTIVE
5 R01 DK058037-07 (Attie)
NIH/NIDDK
The Genetics of Obesity and Diabetes.
06/01/06 – 5/31/11
$1,326,388
2.4 calendar
5 R01 GM074244-03 (Broman)
06/01/05 - 05/31/10
0.6
calendar
NIH/NIGMS
$176,956
Statistical Methods and Software for QTL Mapping
This project aims to develop improved model selection methods of multiple QTL mapping in experimental
crosses, develop improved methods for the analysis of recombinant inbred lines and related strains, and
develop and disseminate the R/qtl software for QTL mapping.
R01 GM069430-01 (N Yi, Alabama Birmingham)
06/01/05 - 5/31/08
2.4 calendar
NIH/NIGMS
$185,596
Bayesian Methods for Mapping Complex Epistatic Genes.
This project is to develop Bayesian model selection methods and computer software for mapping epistatic
genes in experimental crosses.
5 R01 DK066369-05 (Attie)
12/01/03 – 11/30/08
2.4 calendar
NIH/NIDDK
$ 3,199,359
Genetic Mapping of Networks Associated with Beta-cell in a Mouse Diabetes Model System.
(no-cost extension)
PENDING
R01 (Dove)
04/01/08 – 3/31/13
NIH/National Cancer Institute (NCI)
$2,082,454
Analyses of progression to colon cancer in a spectrum of pathways (CA063677).
R01 (Nickells)
NIH/National Eye Institute (NEI)
Characterization of RGC death susceptibility alleles.
11/1/08-10/31/13
$1,250,000
OVERLAP
NONE
PHS 398/2590 (Rev. 11/07)
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0.24 calendar
0.6 calendar