For New and Renewal Applications (PHS 398) – DO NOT SUBMIT UNLESS REQUESTED PHS 398 OTHER SUPPORT ANDERSON, R.R. ACTIVE R01 HL 0000002 (Anderson) 03/1/10– 02/28/16(NCE) 5.60 calendar NIH/NHLBI5 $186,529 Chloride and Sodium Transport in Airway Epithelial Cells11 The major goals of this project are to define the biochemistry of chloride and sodium transport in airway epithelial cells and clone the gene(s) involved in transport.12 R01 HL 123456 (Baker) 04/01/12 – 03/31/17 4.20 calendar NIH/NHLB $122,717 (sub only) Ion Transport in Lungs The major goal of this project is to study chloride and sodium transport in normal and diseased lungs. PENDING R01 HL 222222 (Anderson) 12/01/15 – 11/30/20 3.20 calendar NIH/NHBI $185,999 Transepithelial sodium and water transport in the lung The major goals of this project is to study the mechanisms that augment transepithelial sodium transport and enhance the clearance of alveolar edema may lead to more effective prevention or treatment for pulmonary edema and acute lung injury DCB 950000 (Anderson) 12/01/15 – 11/30/20 2.40 calendar National Science Foundation $82,163 Liposome Membrane Composition and Function The major goals of this project are to define biochemical properties of liposome membrane components and maximize liposome uptake into cells. OVERLAP Potential commitment overlap exists. If application under consideration is funded, Dr. Anderson will request approval to reduce her effort on R01 HL 000000 to 4.00 calendar months. If other pending applications are funded, Dr. Anderson will reduce her effort appropriately. HERNANDEZ, M. ACTIVE P01 CA 223333 (Chen) 07/01/13 – 06/30/18 3.80 calendar NIH/NCI $104,428 Mutations in p53 in Progression of Small Cell Lung Carcinoma The major goals of this subproject are to define the p53 mutations in SCLC and their contribution to tumor progression and metastasis. *The average effort for this budget period is 5 calendar months P01 CA118816 (Chang) 07/01/12 – 06/30/17 see below NIH Imaging and Tissue Correlates to Optimize Management of Glioblastoma The overall objective of this Program Project Grant (PO1) is to integrate advances in physiologic and metabolic imaging with ex vivo biological and genetic information obtained from the analysis of image guided tissue samples in order to optimize the management of patients with glioblastoma (GBM). Project 1 (Jones) $371,782 Improved management of GBM by integrating imaging and tissue analysis 0.60 calendar The goal of this project is to develop and test novel MR metabolic imaging approaches that will help to distinguish recurrent tumor from normal brain and treatment effects in patients with glioblastoma (GBM). Project 2 (Murphy) $308,828 1.20 calendar Image Guided Genome-Epigenome Analysis of Tumor Heterogeneity and Evolution Our goal is to identify naturally evolving and treatment-induced mutations and epimutations that promote the selective outgrowth of malignant subclones over time. PENDING: BE 555555 (Hernandez) 12/01/15 – 11/30/20 1.80 calendar American Cancer Society $86,732 p53 Mutations in Breast Cancer The major goals of this project are to define the spectrum of p53 mutations in human breast cancer samples and correlate the results with clinical outcome. OVERLAP There is scientific overlap between aim 2 of ACS BE 00000 and aim 4 of the application under consideration. If both are funded, the budgets will be adjusted appropriately in conjunction with agency staff.