1
Supplementary Table 1 Association of each SNP with COPD in population A
Number of subjects for
SNP (Genotype)
p-value for each model
each genotype
COPD
At risk
Dominant Recessive Additive
rs726288 (GG/GA/AA)
126/58/4
63/16/2
0.046
0.817
0.068
rs721917 (CC/CT/TT)
74/81/33
26/29/27
0.324
0.003*
0.021
rs10887199 (TT/TC/CC) 65/87/36
42/28/23
0.008*
0.579
0.035
rs911886 (GG/GA/AA)
71/85/26
41/29/10
0.060
0.676
0.119
rs911887 (AA/AG/GG)
98/74/16
39/34/9
0.522
0.665
0.495
36/33/13
0.326
0.448
0.283
rs2819097 (CC/CG/GG) 94/73/21
2
*p < 0.010 was considered significant as indicated in the Materials and Methods
3
section.
4
5
1
1
Supplementary Table 2 Hardy–Weinberg equilibrium of SFTPD gene polymorphisms
p-values for testing Hardy–Weinberg equilibrium
Population A
Population B
Subjects
Subjects with
SNP
COPD
At risk
without
emphysema
emphysema
rs726288
0.366
0.432
rs721917
0.191
0.008
0.389
0.075
rs10887199
0.477
0.055
0.437
0.418
rs911886
0.945
0.189
rs911887
0.703
0.700
rs2819097
0.241
0.252
2
3
2
1
Supplementary Table 3 Correlation matrix of the SNPs of SFTPD
rs726288
2
rs721917
rs10887199 rs911886
rs911887
rs2819097
rs726288
1
0.374082
0.543016
0.576018
0.281266
0.211094
rs721917
0.374082
1
0.671683
0.59088
0.095351
0.506886
rs10887199
0.543016
0.671683
1
0.890226
0.515039
0.27486
rs911886
0.576018
0.59088
0.890226
1
0.478583
0.291363
rs911887
0.281266
0.095351
0.515039
0.478583
1
0.357006
rs2819097
0.211094
0.506886
0.27486
0.291363
0.357006
1
Note: Pairwise correlations are given in italics.
3
4
3
1
Supplementary Table 4 Correlation matrix of the phenotypes
FEV1%
phenotypes
%DLCO/VA LAA%
LAA%-U
WA%
1
0.3886
-0.5596
-0.4522
-0.2957
%DLCO/VA
0.3886
1
-0.683
-0.6853
0.08
LAA%
-0.5596
-0.683
1
0.9289
-0.0249
LAA%-U
-0.4522
-0.6853
0.9289
1
-0.0079
WA%
-0.2957
0.08
-0.0249
-0.0079
1
predicted.
FEV1%
predicted
2
Note: Pairwise correlations are given in italics.
3
4
4
1
Supplementary Table 5 Association of each SNP with emphysema in population B
Number of subjects for each
SNP (Genotype)
p-value for each model
genotype
Emphysema Not emphysema
Dominant Recessive Additive
rs721917 (CC/CT/TT)
66/77/17
309/505/157
0.474
0.280
0.177
rs10887199 (TT/TC/CC)
48/75/37
332/482/157
0.280
0.474
0.085
2
3
5
1
Supplementary Table 6 The association between the SNPs of SFTPD and the serum
2
concentration or the phenotypes of COPD in population A.
3
p-values on correlation
Serum concentration of
SNPs
SFTPD (log transformed)
rs726288
1.1 × 10-6*
rs721917
7.0 × 10-11*
rs10887199
5.0 × 10-12*
rs911886
7.1 × 10-9*
rs911887
0.19
rs2819097
0.0024*
4
*p < 0.010 was considered significant as indicated in the Materials and Methods
5
section.
6
6