Supplementary Figure 1 (Appendix). Functional investigation of the associated
HNF4A variants. A, HNF4A gene structure, locations of the SNPs and haplotype
combinations. H1 and H2 indicate the haplotypes. B, Display of evolutionary
conservation in human, chimp, mouse, rat, and dog, for the investigated SNP region
(~225-bp) from UCSC Genome Browsers conservation track. The approximate position
of the investigated SNP is marked by an arrow head (▼). C, The positions of the SNPs in
the human reference sequence (UCSC Genome Browser, Build 35); predicted changes in
TF binding sites using the ElDoradoTM tool, release 3.0.; and the pairwise conservation
alignment. The investigated SNP is designated in bold. The PhastCons program, at the
UCSC website (www.genome.ucsc.edu/), was used for evolutionary and pairwise
conservation alignments.
Supplementary Figure 1.