CHE499
TRANSPORT MODELING
Spring 2004
GRADE:
No late homework. No make-up quizzes or tests
A : 93-100%, A- : 90-93% , B+ : 87-90% , B : 83-87% , B- : 80-83%
C+ : 77-80% , C : 73-77% , C- : 70-73%
D+ : 67-70% , D : 60-67% , F : 0-60%
GRADING SCALE 1
Homework (best 9 of 10 assignments)
Best 4 of 5 biweekly quizzes
Final
Case Study (Optional)
15%
45%, closed books and closed notes
40 %
5%
OPTIONAL GRADING SCALE 2
Homework (best 9 of 10 assignments)
Best 4 of 5 biweekly quizzes
Case Study
15%
45%, closed books and closed notes
40 %
Please sign and return this form by April 12 2004 to be considered for the optional grading scale
2
Your name ___________________________
Your signature __________________________
Date ________________
CHE 499
CASE STUDY ASSIGNMENT (Spring 04)
Due: Friday May 28 2004 at 9:00 AM
Transport Phenomena in Biomedical Engineering
This is a case study that you must select based on any topics related to Transport
Phenomena in Biomedical Engineering. A list of acceptable topic is available so you can pick a
topic from the list, the first person signing the name next to the topic will be responsible for it.
You must read at least 5 references and turn in a copy of your main reference excluding the
text materials. You can start with the text materials and the references listed in the text, page 289.
Your case study must be quantitative. There must be an equation or set of equations presented to
describe the transport phenomena. The solutions to the equation(s) must also be presented and
discussed. You can work alone or in a group of 2 and turn in one report. Group of 2 must
give an oral presentation for the full credit. Oral presentation is optional for 1 person. Oral
presentation is about 20 minutes per group.
Grading criteria:
Presentation of relevant information (20%)
- You must present your case study with a typed-written title page and an executive
summary. The format for the title page is given in the opposite page. You need to assign a title to
your case study.
- You must write an introduction (backgrounds materials) for the topic before you
describe the transport model, its significances and applications. You must provide all the
necessary information toward the solution of the model. You should include picture(s) to
illustrate the description.
Model development (20%)
- Make a sketch of the system
- List all the assumptions, physical properties, and parameters.
- Derive the equations for your system in details.
Solution (20%)
- Solve the transport model analytically or by using any software package (You can use
POLYMATH, MATLAB, MATCAD...).
- Verify and present the results in graphical form. You should plot the dependent
variable(s) versus the independent variable(s) with a realistic set of parameters. You are to plot
the effect of perturbations (+/- 50%) of these parameters on the dependent variable(s).
Discussion of results (20%)
- Discuss the assumptions and the solutions and possible applications of the solution.
Computer disk (10%)
- A computer disk that contains your report, your Powerpoint presentation and any
relevant materials.
General completeness and neatness (10%)
- Your report should contain: (A sample report is available)
1. Title page.
2. Executive summary: This should succinctly summarize your problem, your results,
and your conclusions. This summary should not exceed two typed written pages.
3. Transport Model: This should contain an introduction and detailed description of
the model.
4. Model Solution: This should contain solution, and results in graphical form.
5. Discussion. This should contain your analysis of the results and the application.
6. Appendices: This should contain any relevant materials (EX: Derivation of
equation(s), your computer program, computer output, reference literature, disk, ...)
California State Polytechnic University, Pomona
Chemical&Materials Engineering Department
CHE 499 : TRANSPORT MODELING
CASE STUDY
The Performance of a Bioartificial Pancreas
Date: May 28 2004
by
Last name, first
Last name, first
This case study is given under the Honor System and by signing here
__________________________ , ________________________
We have agreed that the work submitted is our work alone and that we neither sought nor
received help from others.
Presentation
Model development
Solution
Discussion
Computer disk (CD)
Completeness and Neatness
20%
20%
20%
20%
10%
10%
________
________
________
________
________
________
Report must have comb binding with CD attached to the back cover.
Lists of acceptable topics:
Name
(1) Numerical solution for the oxygen concentrations
within the blood and tissue regions
________________________
(2) Diffusion of urea in both stagnant and flowing
blood (Colton and Lowrie 1981)
________________________
(3) The sieving coefficient for the case of concentration
polarization (Mochizuki and Zydney 1992)
________________________
(4) Hindered transport of large molecules in
liquid-filled pores (Deen 1987)
________________________
(5) Modeling of oxygen uptake in perfluorocarbon
emulsions (Shah 1996)
________________________
(6) First-Order Drug Absorption and Elimination
________________________
(7) A Two-Compartment Model for an Intravenous
Injection
________________________
(8) A A Two-Compartment Model for First Order
Absorption
________________________
(9) Analysis of a Membrane Oxygenator, Oxygen
Transfer
________________________
(10) Analysis of a Membrane Oxygenator, Carbon
Dioxide Transfer
________________________
(11) Reactor Design Equation: Packed-Bed Reactor,
Well-Mixed Reactor
________________________
(12) Pharmacokinetic Modeling of Inulin Transport
in a Polymeric Support Structure
________________________
(13) Islet Insulin Release Model
________________________
(14) Pharmacokinetic Modeling of Glucose and
Insulin Interactions
________________________
(15) Using the Pharmacokinetic Model to Evaluate
the Performance of a Bioartificial Pancreas
________________________
(16)* Oscillating Flow in a Cylindrical Tube
________________________
(17)* Model of Diffusion of a Solute into a Sphere
________________________
(18)* Transport Effects Upon Enzymatic Reactions
________________________
(19)* Transport Effects Upon Enzymatic Reactions
________________________
(20)* Receptor-Ligand Binding Kinetics
________________________
(21)* A Kinetic Model for LDL Receptor-Mediated
Endocytosis
________________________
(22)* Receptor Regulation during Receptor-Mediated
Endocytosis
________________________
(23)* Simplified Model for Gene Induction and Expression ________________________
(24)* Biophysics of Leukocyte Rolling and Adhesion
________________________
(25)* Stochastic Effects on Chemical Interactions
________________________
(26)* Dynamics of Oxygenation of Blood in Lung Capillaries
________________________
(27)* Nitric Oxide Production and Transport in Tissues
________________________
(28)* Unidirectional Transport in a Solid Tumor
________________________
(29)* Pharmacokinetic Analysis of Methotrexate
________________________
(30)* Allometric Scaling Law in Pharmacokinetic Analysis ________________________
*
Transport Phenomena in Biological Systems by Truskey, Yuan, and Katz, Prentice Hall,
2004