Last data updates: 06 January 2011
Han, J.S. and Wang, Q. (1992), Mobilization of specific neuropeptides by peripheral stimulation of
identified frequencies. News in Physiological Sciences, 7, 176-180.
Document type: Article Language: English Cited references: 0 Time cited: 37
Times self cited:
19
Abstract: Three families of endogenous opioid peptides have been characterized in the CNS:
enkephalins, endorphins and dynorphins. These can be mobilized by peripheral electrical
stimulation. Stimulation at 2 Hz may accelerate the release of enkephalins and beta-endorphin,
whereas 100 Hz is most effective in releasing dynorphin.
Reprint Address: Han, JS (reprint author), Beijing Med Univ, Dept Physiol, Beijing 100083,
Peoples R China
1.
Meade, C.S., Lukas, S.E., McDonald, L.J., Fitzmaurice, G.M., Eldridge, J.A., Merrill, N. and
Weiss, R.D. (2010), A randomized trial of transcutaneous electric acupoint stimulation as
adjunctive treatment for opioid detoxification. Journal of Substance Abuse Treatment, 38 (1),
12-21.
2.
3.
Han, J.S. (2009), Acupuncture Research Is Part of My Life. Pain Medicine, 10 (4), 611-618.
Cui, C.L., Wu, L.Z. and Luo, F. (2008), Acupuncture for the treatment of drug addiction.
4.
Neurochemical Research, 33 (10), 2013-2022.
Li, Y., Zhang, Y., Han, J.S. and Wang, Y. (2008), Distinct responses of DREAM to
electroacupuncture stimulation with different frequencies during physiological and
5.
inflammatory conditions in rats. Neurochemical Research, 33 (10), 2070-2077.
Overstreet, D.H., Cui, C.L., Ma, Y.Y., Guo, C.Y., Han, J.S., Lukas, S.E. and Lee, D.Y.W.
(2008), Electroacupuncture reduces voluntary alcohol intake in alcohol-preferring rats via an
6.
opiate-sensitive mechanism. Neurochemical Research, 33 (10), 2166-2170.
Yang, C.H., Lee, B.H. and Sohn, S.H. (2008), A possible mechanism underlying the
effectiveness of acupuncture in the treatment of drug addiction. Evidence-Based
7.
Complementary and Alternative Medicine, 5 (3), 257-266.
Shuai, X., Xie, P., Liu, J., Xiang, Y., Li, J. and Lan, Y. (2008), Different effects of
electroacupuncture on esophageal motility and serum hormones in cats with esophagitis.
8.
Diseases of the Esophagus, 21 (2), 170-175.
Tong, K.C., Lo, S.K. and Cheing, G.L. (2007), Alternating frequencies of transcutaneous
electric nerve stimulation: Does it produce greater analgesic effects on mechanical and thermal
pain thresholds? Archives of Physical Medicine and Rehabilitation, 88 (10), 1344-1349.
9. Zheng, Z., Li, S., Sha, H., Xie, Y.K. and Luo, Z.C. (2005), An acupuncture-like quantitative
mechanical stimulator. 2005 27th Annual International Conference of the IEEE Engineering in
Medicine and Biology Society, Vols 1-7, 4939-4942.
10. Yang, H., Chang, J.Y., Woodward, D.J., Baccala, L.A., Han, J.S. and Luo, F. (2005), Coding
of peripheral electrical stimulation frequency in thalamocortical pathways. Experimental
Neurology, 196 (1), 138-152.
11. Kuo, Y.L., Chiu, J.H., Lin, J.G., Hsieh, C.L. and Wu, C.W. (2005), Localization of
cholecystokinin and vasoactive intestinal peptide in lower biliary tract in cats following
electroacupuncture on right Qimen (LR14) and Riyue (GB 24): an immunohistochemistry
study. Acupuncture & Electro-Therapeutics Research, 30 (1-2), 15-25.
12. Law, P.P.W. and Cheing, G.L.Y. (2004), Optimal stimulation frequency of transcutaneous
electrical nerve stimulation on people with knee osteoarthritis. Journal of Rehabilitation
Medicine, 36 (5), 220-225.
13. Sun, R.Q., Wang, H.C., Wan, Y., Jing, Z., Luo, F., Han, J.S. and Wang, Y. (2004),
Suppression of neuropathic pain by peripheral electrical stimulation in rats: mu-opioid receptor
and NMDA receptor implicated. Experimental Neurology, 187 (1), 23-29.
14. Huang, C., Hu, Z.P., Long, H., Shi, Y.S., Han, J.S. and Wan, Y. (2004), Attenuation of
mechanical but not thermal hyperalgesia by electroacupuncture with the involvement of
opioids in rat model of chronic inflammatory pain. Brain Research Bulletin, 63 (2), 99-103.
15. Tabosa, A., Yamamura, Y., Forno, E.R. and Mello, L.E.A.M. (2004), A comparative study of
the effects of electroacupuncture and moxibustion in the gastrointestinal motility of the rat.
Digestive Diseases and Sciences, 49 (4), 602-610.
16. Wang, N. and Hui-Chan, C. (2003), Effects of acupoints TENS on heat pain threshold in
normal subjects. Chinese Medical Journal, 116 (12), 1864-1868.
17. Han, J.S. (2003), Acupuncture: neuropeptide release produced by electrical stimulation of
different frequencies. Trends in Neurosciences, 26 (1), 17-22.
18. Cao, X.D. (2002), Scientific bases of acupuncture analgesia. Acupuncture &
Electro-Therapeutics Research, 27 (1), 1-14.
19. Cui, C.L., Wu, L.Z. and Han, J.S. (2000), Spinal kappa-opioid system plays an important role
in suppressing morphine withdrawal syndrome in the rat. Neuroscience Letters, 295 (1-2),
45-48.
20. Huang, C., Wang, Y., Chang, J.K. and Han, J.S. (2000), Endomorphin and mu-opioid
receptors in mouse brain mediate the analgesic effect induced by 2 Hz but not 100 Hz
electroacupuncture stimulation. Neuroscience Letters, 294 (3), 159-162.
21. Barlas, P., Robinson, J., Allen, J. and Baxter, G.D. (2000), Lack of effect of acupuncture upon
signs and symptoms of delayed onset muscle soreness. Clinical Physiology, 20 (6), 449-456.
22. Wang, B., Luo, F., Zhang, W.T. and Han, J.S. (2000), Stress or drug priming induces
reinstatement of extinguished conditioned place preference. Neuroreport, 11 (12), 2781-2784.
23. Wang, B., Luo, F., Xia, Y.Q. and Han, J.S. (2000), Peripheral electric stimulation inhibits
morphine-induced place preference in rats. Neuroreport, 11 (5), 1017-1020.
24. Han, Z., Jiang, Y.H., Wan, Y., Wang, Y., Chang, J.K. and Han, J.S. (1999), Endomorphin-1
mediates 2 Hz but not 100 Hz electroacupuncture analgesia in the rat. Neuroscience Letters,
274 (2), 75-78.
25. Chiu, J.H., Kuo, Y.L., Lui, W.Y., Wu, C.W. and Hong, C.Y. (1999), Somatic electrical nerve
stimulation regulates the motility of sphincter of Oddi in rabbits and cats - Evidence for a
somatovisceral reflex mediated by cholecystokinin. Digestive Diseases and Sciences, 44 (9),
1759-1767.
26. Chiu, J.H., Chen, W.S., Chen, C.H., Jiang, J.K., Tang, G.J., Lui, W.Y. and Lin, J.K. (1999),
Effect of transcutaneous electrical nerve stimulation for pain relief on patients undergoing
hemorrhoidectomy - Prospective, randomized, controlled trial. Diseases of the Colon &
Rectum, 42 (2), 180-185.
27. Ramsay, D.J., Bowman, M.A., Greenman, P.E., Jiang, S.P., Kushi, L.H., Leeman, S., Lin,
K.M., Moerman, D.E., Schnoll, S.H., Walker, M., Waternaux, C. and Wisneski, L.A. (1998),
Acupuncture. Jama-Journal of the American Medical Association, 280 (17), 1518-1524.
28. Wang, H.H., Chang, Y.H., Liu, D.M. and Ho, Y.J. (1997), A clinical study on physiological
response in electroacupuncture analgesia and meperidine analgesia for colonoscopy. American
Journal of Chinese Medicine, 25 (1), 13-20.
29. Guo, H.F., Tian, J.H., Wang, X.M., Fang, Y., Hou, Y.P. and Han, J.S. (1996), Brain substrates
activated by electroacupuncture of different frequencies .1. Comparative study on the
expression of oncogene c-fos and genes coding for three opioid peptides. Molecular Brain
Research, 43 (1-2), 157-166.
30. Liu, N.J., Bao, H., Li, N., Yu, Y.X. and Han, J.S. (1996), Cholecystokinin octapeptide reverses
the inhibitory effect induced by electroacupuncture on C-fiber evoked discharges.
International Journal of Neuroscience, 86 (3-4), 241-247.
31. Hsu, D.T. (1996), Acupuncture - A review. Regional Anesthesia, 21 (4), 361-370.
32. Guo, H.F., Cui, X., Hou, Y.P., Tian, J.H., Wang, X.M. and Han, J.S. (1996), C-Fos proteins
are not involved in the activation of preproenkephalin gene expression in rat brain by
peripheral electric stimulation (electroacupuncture). Neuroscience Letters, 207 (3), 163-166.
33. Han, J.S. (1995), Cholecystokinin octapeptide (CCK-8): A negative feedback control
mechanism for opioid analgesia. Gene Expression in the Central Nervous System, 105,
263-271.
34. Futaesaku, Y., Zhai, N., Ono, M., Watanabe, M., Zhao, J.G., Zhang, C.S., Li, L. and Shi, X.M.
(1995), Brain Activity of A Rat Reflects Apparently the Stimulation of Acupuncture - A
Autoradiography Using 2-Deoxyglucose. Cellular and Molecular Biology, 41 (1), 161-170.
35. Han, J.S., Wu, L.Z. and Cui, C.L. (1994), Heroin-Addicts Treated with Transcutaneous
Electrical Nerve-Stimulation of Identified Frequencies. Regulatory Peptides, 54 (1), 115-116.
36. Chen, X.H., Han, J.S. and Huang, L.T. (1994), CCK Receptor Antagonist L-365,260
Potentiated Electroacupuncture Analgesia in Wistar Rats But Not in Audiogenic Epileptic Rats.
Chinese Medical Journal, 107 (2), 113-118.
37. Han, J.S., Chen, X.H., Yuan, Y. and Yan, S.C. (1994), Transcutaneous Electrical
Nerve-Stimulation for Treatment of Spinal Spasticity. Chinese Medical Journal, 107 (1), 6-11.