Last data updates: 06 January 2011
Guo, H.F., Tian, J.H., Wang, X.M., Fang, Y., Hou, Y.P. and Han, J.S. (1996), Brain substrates
activated by electroacupuncture (EA) of different frequencies .2. Role of Fos/Jun proteins in
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Document type: Article Language: English Cited references: 35 Time cited: 30 Times self cited: 8
Abstract: Antisense oligodeoxynucleotides (ODNs) of c-fos and/or c-jun were used in this study to
investigate the role of Fos and Jun proteins in electroacupuncture (EA)-induced transcription of the
opioid genes preproenkephalin (PPE), preprodynorphin (PPD) and proopiomelanocortin (POMC).
As the results showed, EA-induced Fos and Jun expression was blocked efficiently and specifically
by c-fos and c-jun antisense ODNs, respectively. This treatment significantly prevented EA-induced
PPD, but not PPE, mRNA expression. These results suggest that Fos and Jun proteins are involved
in PPD rather than PPE gene transcription activated by EA stimulation.
Author Keywords: electroacupuncture; Fos; Jun; preproenkephalin; preprodynorphin; antisense
oligodeoxynucleotide
Keywords Plus: C-Fos; Messenger-Rna; Prodynorphin Gene; Rat Striatum; Molecular Mechanisms;
Antisense Oligonucleotide; Proenkephalin Gene; Spinal-Cord; Expression; Jun
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