Continuing Medical Education The Department of Psychiatry and Human Behavior The Alpert Medical School of Brown University October 2007 ACADEMIC GRAND ROUNDS Wednesday, October 3rd 11:00 am - 12:15pm Ray Conference Ctr. Butler Hospital John H. Krystal, MD Topic: “Glutamate, Prefrontal Cortex, and Schizophrenia: Capturing the Angel in Angel Dust” Robert L. McNeil, Jr. Professor of Clinical Pharmacology Deputy Chairman for Research, Department of Psychiatry Yale University School of Medicine Ribicoff Research Facilities, CMHC Objectives: At the conclusion of this presentation participants should be able to: 1) Describe the contributions of abnormalities in glutamate neurotransmission to the neurobiology of schizophrenia; 2) Identify working memory as a prototypic cognitive impairment in schizophrenia in order to illustrate the nature of prefrontal/cortical functional impairments and to show how these impairments may be modeled by the effects of blockade of NMDA glutamate receptors upon both excitatory and inhibitory neurotransmission; and 3) Discuss the rationale for testing drugs that directly or indirectly enhance NMDA glutamate receptors or, paradoxically, reduce hyperactivity of the glutamate system in the treatment of schizophrenia. Accreditation: Physicians: The Alpert Medical School of Brown University is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The Alpert Medical School designates this educational activity for a maximum of 1 hour of AMA PRA Category 1 Credit TM. Physicians should claim only credit commensurate with the extent of their participation. Psychologists: The Alpert Medical School of Brown University has been approved by the Rhode Island Psychological Association to offer continuing education credits for Psychologists. The Alpert Medical School of Brown University maintains responsibility for the program. This program is approved for Category 1 CE credit. For More Information call Kristen Schroeder at 401-455-6430 CHILD AND ADOLESCENT PSYCHIATRY GRAND ROUNDS Wednesday, October 10th Bradley Hospital Pine Room 11:00 – 12:15pm Topic: Daniel Dickstein, MD Assistant Professor of Psychiatry and Human Behavior The Alpert Medical School of Brown University Director, Pediatric Mood, Imaging, & Neurodevelopment Program E.P. Bradley Hospital “Pictures Worth 1000 Words: Advances in Child Psychiatry through Neuroimaging” Objectives: At the end of this presentation audience members will be able to: 1) Discuss how neuroimaging works; 2) Review recent neuroimaging studies have enhanced our understanding of typical development; and 3) Describe how neuroimaging studies are advancing what is known about childhood psychiatric conditions, including bipolar disorder. Accreditation: Physicians: The Alpert Medical School of Brown University is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The Alpert Medical School designates this educational activity for a maximum of 1 hour of AMA PRA Category 1 Credit TM. Physicians should claim only credit commensurate with the extent of their participation. Psychologists: The Alpert Medical School of Brown University has been approved by the Rhode Island Psychological Association to offer continuing education credits for Psychologists. The Alpert Medical School of Brown University maintains responsibility for the program. This program is approved for Category 1 CE credit. For More Information call Gail Mills at 401-444-7573 Wednesday, October 17th Bradley Hospital Pine Room 11:00-12:15pm CASE PRESENTATION Daisy Bassen, MD House Staff Officer in Psychiatry (Child Psychiatry)