Online Resource 1 belonging to ‘Cord blood 25(OH)D levels and the subsequent
risk of lower respiratory tract infections in early childhood – results of the Ulm
Birth Cohort’.
Anna Łuczyńska1,4 , Chad Logan2,4 , Alexandra Nieters1,*, Magdeldin Elgizouli1, Ben
Schöttker3, Hermann Brenner3, Dietrich Rothenbacher2,34
1
Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg,
Germany
2
Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany
3
Division of Clinical Epidemiology and Aging Research, German Cancer Research
Center, Heidelberg, Germany
4
These authors contributed equally to this work
*Correspondence to: Alexandra Nieters, Center for Chronic Immunodeficiency (CCI),
Molecular Epidemiology, University Medical Centre Freiburg, Engesser Strasse 4, D79108 Freiburg. Germany. +49 761 270 78150 (phone), Email:
alexandra.nieters@uniklinik-freiburg.de
1
Online resource 1. Comparison of the baseline population to the follow up
population at 1 year-missing data analysis
All Subjects at Baseline
n
% or mean
(95%CL)
n
% or
mean
Missing
7
0.7
(0.3; 1.3)
4
0.5
Vaginal
879
82.5
(80.0; 84.7)
647
83.3
Cesarean section
180
16.9
(14.7; 19.3)
126
16.2
.
.
Variable
Birth delivery mode (vaginal or c-section)
Category
.
Gender
Male
540
50.7
(47.6; 53.7)
398
51.2
Female
526
49.3
(46.3; 52.4)
379
48.8
.
.
.
Gestational age
≥ 37 weeks gestation
1012
94.9
(93.4; 96.2)
741
95.4
< 37 weeks gestation
54
5.1
(3.8; 6.6)
36
4.6
.
.
.
Maternal BMI (kg/m2)
Missing
11
1.0
(0.5; 1.8)
5
0.6
Underweight (<18.5)
50
4.7
(3.5; 6.1)
30
3.9
Normal (18.5 to <25)
728
68.3
(65.4; 71.1)
542
69.8
Overweight (25 to < 30)
203
19.0
(16.7; 21.5)
142
18.3
Obese (≥30.00)
74
6.9
(5.5; 8.6)
58
7.5
.
.
776
31.6
.
.
.
Maternal age rounded to 0.1 (years)
1065
31.0
(30.7; 31.3)
.
Maternal allergy (hayfever, asthma, or
atopic eczema)
Mother reported no atopic allergy
783
73.5
(70.7; 76.1)
561
72.2
Mother reported a type of atopic
allergy
283
26.5
(23.9; 29.3)
216
27.8
.
.
.
Maternal education
Missing
28
2.6
(1.8; 3.8)
12
1.5
10 years of education or more
788
73.9
(71.2; 76.5)
615
79.2
Less than 10 years of education
250
23.5
(20.9; 26.1)
150
19.3
.
.
.
Maternal smoking at delivery
Missing
82
7.7
(6.2; 9.5)
4
0.5
Non-smoker
851
79.8
(77.3; 82.2)
697
89.7
Smoker
133
12.5
(10.6; 14.6)
76
9.8
.
.
642
82.6
.
Mother’s country of birth
Study population
Germany
848
79.5
(77.0; 81.9)
2
All Subjects at Baseline
Variable
Category
Other
Study population
n
% or mean
(95%CL)
n
% or
mean
218
20.5
(18.1; 23.0)
135
17.4
.
.
.
Maternal smoking during pregnancy
Missing
1
0.1
(0.0; 0.5)
.
.
No
906
85.0
(82.7; 87.1)
693
89.2
Yes
159
14.9
(12.8; 17.2)
84
10.8
.
.
.
Maternal vitamin D supplementation
No
1054
98.9
(98.0; 99.4)
770
99.1
Yes
12
1.1
(0.6; 2.0)
7
0.9
.
.
.
Season of birth
Winter (Dec-Feb)
244
22.9
(20.4; 25.5)
174
22.4
Spring (Mar-May)
294
27.6
(24.9; 30.4)
200
25.7
Summer (Jun–Aug)
270
25.3
(22.7; 28.1)
204
26.3
Fall (Sept-Nov)
258
24.2
(21.7; 26.9)
199
25.6
.
.
.
Sibling under 5 years old reported
No siblings under 5
657
61.6
(58.6; 64.6)
468
60.2
Child had a sibling under the age of 5
409
38.4
(35.4; 41.4)
309
39.8
.
.
777
31.7
.
.
777
3424.1
.
Vitamin D (nmol/L)
970
30.2
(29.0; 31.4)
.
Birth weight (g)
1064
3391.8
(3363.8; 3419.7)
Differences in characteristics between baseline and 1 year follow-up population are marked in bold
3