Matthew Marthaler
February 5, 2012
Instrumental Chemistry
Capillary Zone Electrophoresis
Block Diagram:
High Voltage
power supply
Plexiglas box
Capillary
Solvent reservoirs
Vendors for this instrument:
Beckman Coulture
Agilent Technologies
Dionex
Lumex
Bio-Rad
Groton Biosystems
WynSep
Detector
Current Flow
Articles where GC is used:
Zamboni G, Bortolotti F, Zaffanello M, De Paoli G, Tagliaro F. Carbohydrate-deficient transferrin
determined in blood microsamples from healthy newborns by using capillary zone
electrophoresis. Scandinavian Journal Of Clinical & Laboratory Investigation [serial online]. April
2007;67(2):191-195. Available from: Academic Search Premier, Ipswich, MA. Accessed February
20, 2012.
Weissinger E, Wittke S, Fliser D, et al. Proteomic patterns established with capillary electrophoresis and
mass spectrometry for diagnostic purposes. Kidney International [serial online]. June
2004;65(6):2426-2434. Available from: Academic Search Premier, Ipswich, MA. Accessed
February 20, 2012.
Schmitz O, Richter E. Capillary zone electrophoresis with on-line blotting for separation and detection of
[sup 32] P-postlabelled DNA adducts. Biomarkers [serial online]. July 2000;5(4):314. Available
from: Academic Search Premier, Ipswich, MA. Accessed February 20, 2012.
Common Uses for Capillary Zone Electrophoresis:
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A variety of synthetic herbicides, pesticides, and pharmaceuticals that are ions or can be
derivatized to yield ions can be separated by CZE (from Principals of Instrumental Analysis book).
Proteins, amino acids, and carbohydrates can be separated by CZE (from Principals of
Instrumental Analysis book).