Titre : Electrophorèse : actualité et place dans le diagnostic du myélome
Title: Electrophoresis : actuality and multiple myeloma diagnosis
Maalouf Haifa, France, Sebia
Electrophoresis for separation and quantification of serum proteins is useful in numerous
pathological situations to make clinical diagnostics, to follow the evolution of a disease or to
evaluate the efficiency of a treatment. The most interesting applications for electrophoresis
today are the specialized tests on agarose gel and the routine tests on capillary electrophoresis.
Combining both technologies allows obtaining both high resolution and maximum sensitivity and
is now recognized as the most successful mix to minimize missing monoclonal component in a
routine laboratory practice. First, we will present an overview about electrophoresis technique
and SEBIA tests available today on the market. Then, we will discuss guidelines and the place of
serum and urine protein electrophoresis in multiple myeloma diagnosis.
Key words: Electrophoresis, serum proteins, agarose gel, capillary electrophoresis,
guidelines, multiple myeloma.