Teacher Background – 7.14AC Heredity A resource document which gives teachers relevant and essential background knowledge on the science concept being addressed. Objective(s): 7.14A Define heredity as the passage of genetic instructions from one generation to the next generation. 7.14C Recognize that inherited traits of individuals are governed in the genetic material found in the genes within the chromosomes in the nucleus. Foundation: Students have previously been introduced to the basic concepts of heredity by examining and being aware of observable traits, such as eye color in humans or shapes of leaves in plants. Such shared characteristics are different from learned behaviors, such as table manners or learning a language. Students have likely also explored the basic concept of a cell and that it contains a nucleus. They may even be aware that each human cell has 46 chromosomes, with all of a person’s DNA organized into two sets of 23 chromosomes. During this grade level, students will begin to get more in-depth in their understanding that constructs called chromosomes contain the DNA for these traits and that traits, such as eye color, are passed from one generation to the next by each parent contributing a set of chromosomes to an offspring. This is why children look similar to their parents. Furthermore, which set of chromosomes gets inherited from each parent is random. This is why siblings born from separate pregnancies look similar but not identical, and why identical twins are just that, because they actually do both carry the same inherited sets of chromosomes. Essentially, the DNA provides the instructions or recipe for “building” an offspring, using the blueprint provided by the combination of the two individual parents. Heredity is not merely observed within single species, however. Mapping the human genome, as well as that of other species, has provided insight into how different species are related to each other. Not only have mammals inherited traits such as mammary glands and hair from a common ancestor, for example, but also about 75% of known human disease genes have a recognizable match in the genome of fruit flies. This infers that humans and fruit flies also share some common ancestry. Students will also learn the difference between genotype and phenotype. A genotype is the genetic makeup of an organism, while the phenotype is a description of how that genotype is expressed in the organism’s morphology and physiology. Furthermore, a genotype for a trait often includes two variations that are referred to as a dominant allele and a recessive allele. When both a dominant allele and a recessive allele are present for a trait, the dominant allele will mask the recessive allele’s expression of the trait. Only when two copies of the recessive allele are present – one from each parent – is the recessive form expressed. This concept is especially easy to understand when examining phenotypic traits that are controlled by single genes. The ability to roll your tongue or the presence of a Widow’s Peak hairline are examples of dominant expression of traits that scientists believe are controlled by a single gene. If a person’s DNA that controls hairline shape contains both the dominant allele (Widow’s peak hairline) and the recessive allele (straight hairline), or a heterozygous state, then the person’s phenotype will show a Widow’s Peak hairline. Individuals who have two recessive alleles, or a recessive homozygous state, for the trait will have a straight hairline. However, not all traits are controlled by single genes. Most inherited traits are controlled by a combination of multiple genes. This fact makes genetic research especially complicated when trying to figure out how defects and risks for disease are configured into a person’s genotype. Surveying generational data, ongoing work on mapping genomes, and other studies continue to further our understanding of how heredity works and how medical professionals can predict, and possibly curb, health risks. Wild animal and plant populations, of course, also demonstrate how traits are inherited. There are eight genetic lineages of felines, for example. Lions, leopards, panthers, servals, cheetahs, pumas, and mountain lions, all share genetic traits inherited from a common ancestor. Genetic similarities can easily be observed between cat species, including teeth, nose, hair, feet, and tail characteristics. Wild populations can suffer, however, when their numbers are reduced. Inbreeding can occur, which results in low genetic variation and often causes what are typically recessive, deleterious traits to show up in the phenotypes in successive generations of offspring. Such growing homozygosity in recessive traits is observable in the Florida Panther, for example. Abnormal phenotypic traits include kinked tails and severe birth defects. The principles of inheritance are also studied and applied in domestication of wild species. Artificial selection, or selective breeding, has produced a variety of livestock breeds and plant types that boost human population survival and growth, while pet breeds provide comfort and companionship. For hundreds of generations, humans have bred together two individuals with desirable traits in order to enhance those desirable traits in their offspring. Unfortunately, also due to the principles of inheritance and the nature of chromosomes and their contained DNA, not all of the desirable traits can be teased from non-desirable traits. A hybrid plant that may produce a high seed yield may also have a higher vulnerability to disease, for example. Desirable traits in a dog breed may also be accompanied by a higher risk of hip dysplasia. The educational groundwork done at this grade level is crucial for understanding the more complex concepts in higher grade levels. More importantly, perhaps, is that these basic concepts of heredity are applicable to multiple real-world fields and applications, such as in our everyday casual observations and conversations, medicine, wildlife conservation, and food supplies.