NovaMin
What is NovaMin®?
A “high-tech” active ingredient used in the
most innovative professional dental products.
Material Description
 NovaMin is a breakthrough
remineralization technology.
 A tasteless white powder form.
 NovaMin amplifies the natural
protective and repair mechanisms
for teeth and gums.
 Extensively proven in clinical and
scientific studies at leading dental
schools around the world.
Technical Breakdown
 Comprised of calcium,
sodium, phosphorous
and silica, all natural
elements found in the
body
 Chemical name is Calcium Sodium
Phosphosilicate
 NovaMin is recognized as the only man
made ingredient that directly leads to the
formation of new tooth mineral
(HCA)
What Does NovaMin® Do?
Repairs Surface Lesions
Forms biomimetic HCA on
tooth dentin and enamel
surface lesions
Reduces Sensitivity
Occludes dentin tubules:
forms a protective
biomimetic HCA layer.
Improves Gingival Health
Antimicrobial properties &
Anti-inflammatory
properties reduce gingivitis.
The NovaMin® Solution
Hard Tissue Benefits
The NovaMin® Solution
Soft Tissue Benefits
NovaMin: How it Starts
NovaMin is also called “calcium
sodium phosphosilicate”.
It is made from elements
naturally found in healthy teeth
and bones:
Calcium ( ), Phosphorus ( ),
Sodium ( ) and Silicon ( )
Step 1: pH Elevation
+H2O
NovaMin reacts with
saliva. Na+ ions release,
elevating pH into the
range essential for
HCA formation.
8.0-8.5
pH
Step 2: Mineral Release
Ca2+ and P5+
ions are
released,
saturating saliva
with the ions
needed for
remineralization.
Ca2+
P5+
Step 3: Bacterial Kill
Na+ and Ca2+ ions
overwhelm bacterial
cells’ ability to regulate
their water content,
leading to lysis (cell
death) of harmful
bacteria in the mouth.
F. Nucleatum
S. Mutans
A.Naeslundii
-99.99%
S. Sanguis
-99.999%
-99.999%
-99.99999%
Tooth Mineral Structure - Hydroxy-carbonate Apatite (“HCA”)
Step 4: Crystal Building
Enamel Crystal Prism
Demineralized
lesions attract
Ca2+ and P5+ ions,
where they build
new HCA crystal to
remineralize the
defect from the
bottom up.
Tooth Mineral Structure - Hydroxy-carbonate Apatite (“HCA”)
Step 5: Time Release
Enamel Crystal Prism
NovaMin particles
adhere to tooth
surfaces for up to 7
days, continuing to
release Na+, Ca2+, and
P5+ ions to maintain
elevated pH at the
tooth surface and
foster remineralization
over time.
Remineralization of Dentin & Enamel
In-vitro Study – In-Situ Models
After Treatment
Before Treatment
Surface Lesion
In-vitro
Surface Abrasion
In-Situ
Exposed Dentin
In-vitro
NovaMin Product Focuses
• Sensitivity:
Faster & better results
Addresses symptom, not cause.
• Gingivitis:
Faster results
Less controversial ingredient
• Root Caries/Remineralization:
Adult caries predominantly related to hyposalivation.
NovaMin directly addresses this etiology.
NovaMin & Sensitivity
NovaMin Therapy Paste Results
Clinical Results Vs. Placebo
VAS Score
Averaged Across Methods
8
7
6
5
4
3
2
1
0
NovaMin
Control
p<0.001
Baseline
1 week
2 weeks
3 weeks
4 weeks
NovaMin & Sensitivity
NovaMin Therapy Paste Results
Clinical Results Vs. Other Actives
NovaMin Vs. Potassium Nitrate
8.0
VAS Water
p<0.05
6.0
Potassium Nitrate
4.0
Stannous Fluoride
NovaMin
2.0
0.0
0
2
4
Weeks
12
NovaMin vs. Fluoride
Remineralization of Dentin
NTI-UCSF In-vitro Study – Dentin Remin/Demin Model
1400
Product Tested
1200
7.5% NM/1100 ppm MFP
1
800
7.5% NM
2
600
Company CR 5000 ppm NaF 3
1000
Delta Z
Code
400
Company CG 1.1 ppm MFP
4
0% NM/O ppm F
5
200
0
1
2
3
Product Code Tested
4
5
NovaMin and Gingivitis
Anti-Microbial Properties
Log Reduction in Microbial CFU's - 2 Minute Exposure to 1:3 Dilution
Bacterial Species
0
S mutans
S sanguis
F nucleatum
A naeslundii
-1
Log Reduction in Viability
-2
-3
-4
-5
-6
-7
-8
-9
NovaMin Non Aqueous Toothpaste
NovaMin Powder
Colgate Red Box Toothpaste
NovaMin and Gingivitis
Pilot Clinical Study – Gingival Bleeding Index
Summary of Gingival Index Findings
1.4
p<0.01
1.2
GBI
1
0.8
-59%
0.6
NovaMin
Placebo
0.4
0.2
0
baseline
6 week
Time Period
NovaMin and Gingivitis
Pilot Clinical Study – Plaque Index
Summary of Plaque Index Findings
1.8
1.6
p<0.025
1.4
PLI
1.2
1
NovaMin
Placebo
0.8
0.6
0.4
0.2
0
baseline
6 week
Time Period
NovaMin/Fluoride Enamel
Remineralization
In-vitro Study – Remin/Demin Model
Surface Lesion
~ 100µm
Sound Enamel
Demineralized
Untreated Sample
Sound Enamel
Fluoride Dentifrice
Treated Sample
Sound Enamel
NovaMin Dentifrice + F
Treated Sample
NovaMin/Fluoride Enamel
Remineralization
In-vitro Study – Remin/Demin Model
Lesion Area
Lesion Area (sq.
microns x1000)
40
p<0.001
30
-30%
-45%
20
10
0
Demin
F paste
Treatment Group
F + NovaMin