Surgical Management of Benign and Malignant conditions of Biliary Tree Houssam G. Osman, M.D. HPB surgery Associate Director, HPB Fellowship Methodist Dallas Medical Center, Dallas ACOS: In-Depth Review - 2014 Kansas city, MO CHOLECYSTITIS Acute cholecystitis Achalculous cholecystitis Gangrenous cholecystitis Emphysematous cholecystitis Imaging: US Treatment options: Antibiotics Cholecystectomy Percutaneous cholecystotomy tube CHOLEDOCHOLITHIASIS • Secondary 85% • Primary 15% - benign biliary strictures - sclerosing cholangitis - choledochal cysts. - parasitic infections CHOLEDOCHOLITHIASIS Conditions • Painful jaundice • Cholangitis • Gallstone pancreatitis • Silent CBD stone CHOLEDOCHOLITHIASIS • Probability of CBD stone American Society of Gastrointestinal Endoscopy Standards of Practice Committee Maple JT, et al.: The role of endoscopy in the evaluation of suspected choledocholithiasis. Gastrointest Endosc. 71 (1):1-9 2010 CHOLEDOCOLITHIASIS Imaging Ultrasound • 1st line • Jaundice + CBD > 10 mm -> stone in 90% of cases • Maybe able to visualize stone MRCP • Most sensitive non invasive study (decreased sensitivity for stones < 5 mm) • Intermediate probability or when ERCP is not feasible CHOLEDOCOLITHIASIS ERCP • ? Therapeutic more than diagnostic? EUS • Comparable efficacy to ERCP but ? less complication I.O.C • Routine Vs selective CHOLEDOCOLITHIASIS Treatment approaches ERCP PTC CBDE BILE DUCT INJURY • Incidence during open cholecystectomy 0.2 – 0.3 % • Incidence during laparoscopic cholecystectomy 0.3 – 0.6% BILE DUCT INJURY Causes of laparoscopic biliary injury • • • • • • • • • Misidentification of the bile ducts as the cystic duct Misidentification of the CBD as the cystic duct Misidentification of the aberrant right sectoral hepatic duct as the cystic duct Improper techniques of ductal exploration Failure to occlude the cystic duct securely Plane of dissection away of gallbladder wall into liver bed Excessive retraction of cystic duct with tenting of CBD Injudicious use of electrocautery Injudicious use of clips Modified from Strasberg SM et al, 1995: An analysis of problem of biliary injury during laparoscopic cholecystectomy. J Am Coll Surg 180: 101-125 William R. Jarnagin and Leslie H. Blumgart, MD. Blumgart's Surgery of the Liver, Pancreas and Biliary Tract, 5th Edition BILE DUCT INJURY Classification of laparoscopic biliary injury William R. Jarnagin and Leslie H. Blumgart, MD. Blumgart's Surgery of the Liver, Pancreas and Biliary Tract, 5th Edition BILE DUCT INJURY Injury recognized at time of surgery • Stop! • Consider your expertise and ask for help • Leave a drain and transfer to HPB surgeon What is HPB surgeon going to do? • Quick return to OR - open approach (likely) • Identify injury and assess concomitant vascular injury • Cholangiogram • Repair: -Roux en Y hepatojejunostomy -Direct repair over T tube BILE DUCT INJURY You are doing a tough laparoscopic cholecystectomy and suspect Mirizzi syndrome, what do you do? Proceed with subtotal cholecystectomy Or Place cholecystotomy tube BILE DUCT INJURY Hold on a second! How can suspect Mirizzi syndrome?? • Long standing gallstone disease • Contracted gallbladder • Jaundice or cholangitis BILE DUCT INJURY You are doing a tough laparoscopic cholecystectomy and suspect Mirizzi syndrome and you perform partial cholecystectomy. You encounter a gush of bile! what is going on? • Mirizzi syndrome type 2: cholecystocholedochal fistula What do you do? • Cholecystocholedochoduodenostomy, or • Hepatojejunostomy William R. Jarnagin and Leslie H. Blumgart, MD. Blumgart's Surgery of the Liver, Pancreas and Biliary Tract, 5th Edition BILE DUCT INJURY Injury recognized postoperatively • Bile leak • Biloma and infection • Juandice Workup • ERCP - diagnostic and therapeutic • MRCP • CT – assess vascular injury and fluid collection • PTC if needed BILE DUCT INJURY Injury recognized postoperatively Control bile leak Drain fluid collection Treat infection Volume resuscitation Electrolyte replacement Delayed repair BILE DUCT CYST Classification Chijiiwa K, Koga A: Surgical management and long-term follow-up of patients with choledochal cysts. Am J Surg 165:238-242, 1993 BILE DUCT CYST Presentation – Adulthood • Asymptomatic (majority) • Biliary colic like symptoms and mild jaundice • Pancreatitis • Liver cirrhosis • Malignancy ( weight loss) Incidence of malignancy 2.5 – 28 % BILE DUCT CYST Treatment Type I : Excision + Roux en Y hepatojejunostomy vs. hepatoduodenostomy Type II: Excision Type III: Trans-duodenal excision vs. endoscopic sphinterotomy Type IV A: Bile duct and hepatic resection and hepatojejunostomy Type IV B: Excision + Roux en Y hepatojejunostomy vs. hepatoduodenostomy +/- sphincteroplasty Type V: Liver resection vs. transplant Cyst excision does not eliminate risk of malignancy PRIMARY SCLEROSING CHOLANGITIS • Associated with IBD mainly UC • Risk of cholangiocarcionoma 1% per year Presentation • Asymptomatic • Liver cirrhosis • Cholangitis – uncommon PRIMARY SCLEROSING CHOLANGITIS Diagnosis • Cholangiography / MRCP • Multifocal strictures Treatment Asymptomatic : Observe Stricture : ERCP vs resection Liver cirrhosis: Transplant Cholangiocarcinoma: Resection EXTRA-HEPATIC CHOLANGIOCARCINOMA Risk factors • Primary sclerosing cholangitis • Bile duct cysts • Biliary parasites; Clonorchis sinensis, Opisthorchis viverrini • ?? sphincterotomy EXTRA-HEPATIC CHOLANGIOCARCINOMA Classification • Perihilar • Mid bile duct - hepatic confluence to cystic duct - rare • Distal bile ducy - distal to cystic duct confluence William R. Jarnagin and Leslie H. Blumgart, MD. Blumgart's Surgery of the Liver, Pancreas and Biliary Tract, 5th Edition EXTRA-HEPATIC CHOLANGIOCARCINOMA Presentation • Jaundice and pruritus • Abnormal LFT • Non specific symptoms and weight loss EXTRA-HEPATIC CHOLANGIOCARCINOMA Distal cholangiocarcinoma - treat like periampullary tumor - whipple Mid duct cholangiocarcinoma - very rare - ? Gallbladder / cystic duct base cancer - bile duct resection and cholecystectomy - assess need to treat like GB cancer; segment 4,5 liver resection EXTRA-HEPATIC CHOLANGIOCARCINOMA Perihilar cholangiocarcinoma - Classification William R. Jarnagin and Leslie H. Blumgart, MD. Blumgart's Surgery of the Liver, Pancreas and Biliary Tract, 5th Edition EXTRA-HEPATIC CHOLANGIOCARCINOMA Perihilar cholangiocarcinoma – Work up - CT - MRCP - ERCP - PTC Tissue diagnosis is not required in patient with potentially resectable EXTRA-HEPATIC CHOLANGIOCARCINOMA Perihilar cholangiocarcinoma – Treatment Resectable - bile duct resection - achieving R0 resection almost always require partial hepatectomy - hepatojejunostomy - adjuvant treatment Unresectable - palliative - transplant in selected cases preceded by neoadjuvanet chemotherapy (Mayo clinic)