Acid Base Balance Respiratory acidosis Respiratory alkalosis Ph < 7.35 co2 > 45 Ph >7.45 co2 < 35 Metabolic acidosis Ph >7.35 HCO3 > 22 Metabolic alkalosis Normal ranges Ph < 7.45 HCO3 < 26 Ph 7.35-7.45 co2 35-45 HCO3 22-26 ALL METRICS Resp. acidosis causes Resp. alkalosis causes Metabolic Acidosis COPD barbiturate overDOSE chest wall abnormality severe pneumothorax atelectaisis gullies barre syndrome hypoventilation Hyperventilation hypoxia, PE,septicemia, encephalitis, brain injury, salicylate poisoning fever, stimulated respiratory center. Mechanical hyperventilation Diabetic ketoacidosis lactic acidosis starvation severe diarrhea renal tubular acidosis GI fistulas shock Severe vomiting gastric suction diuretic therapy potassium deficit excess NAHCO3 intake excess mineralcorticoids Metabolic alkalosis Resp.acidosis symptoms Resp. alkalosis symptoms Metabolic Acidosis sx Metabolic alkalosis sx Rapid shallow respirations Seizures Headache Restlessness and lethargy decreased BP w/ vasodilation deep, rapid breathing, hyperventilation decreased BP tachycardia headache tachycardia hyperkalemia compensatory hypoventilation hyperkalemia decreased bp muscle twitching confusion dysrytmias hypokalemia vasodilation ( warm and flushed dry skin) nausea vomiting diarrhea drowsiness numbness and tingling nausea vomiting and dirrhea tremors disorientation lethargy and confusion confusion and drowsiness muscle cramps muscle weakness and hyper reflexia lightheadedness kussmals respirations(compensatory hyperventilation) tingling in fingers/ toes nausea, vomiting Compensation 1.If PH is normal range acid/ base is fully compensated 2. If PH is out of range and c02 are opposites then you have partial compensation 3. If PH is out of range but either Co2 or Hc03 are normal= uncompensated