Muscle Lecture 1

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Structural Overview

 excitability - responds to stimuli (e.g., nervous impulses) contractility - able to shorten in length extensibility - stretches when pulled elasticity - tends to return to original shape & length after contraction or extension

 motion maintenance of posture heat production

 skeletal:

◦ attached to bones & moves skeleton

◦ also called striated muscle (because of its appearance under the microscope)

◦ voluntary muscle

Smooth:

◦ involuntary muscle

◦ muscle of the viscera (e.g., in walls of blood vessels, intestine, & other 'hollow' structures and organs in the body) cardiac:

◦ muscle of the heart

◦ involuntary

Skeletal muscles -> tendons (connective tissue)

Epimysium - Ensheaths the entire muscle

Skeletal muscles ->numerous subunits or bundles called fasicles (or fascicles).

Perimysium – Connective tissue surrounding

Fascicles

Endomysium – Ensheath muscle cells.

Muscle cells -> Consist of many fibrils (or myofibrils).

Myofibrils – Composed of myofilaments.

Myofilaments – Thick & Thin myofilaments

SARCOLEMMA has holes.

Holes -> TRANSVERSE TUBULES (or T-

TUBULES)

T-Tubules -> Muscle cell and go around the

MYOFIBRILS.

T-Tubules - DO NOT open into the interior of the muscle cell.

Function of T-TUBULES -> Conducts impulses from the surface down to

Sarcoplasmic Reticulum.

SR - like ER, hollow

Primary Function – Store Calcium Ions

Associated with the MYOFIBRILS

Ca "pumps" (active transport) for calcium so that calcium is constantly being "pumped" into the SR from the cytoplasm.

Relaxed muscle - high concentration of Ca in SR/ Low in Sarcoplasm

Impulse travels along the membrane of the SR, the calcium "gates" open &, therefore, calcium diffuses rapidly out of the SR & into the sarcoplasm where the myofibrils & myofilaments are located.

Key step in muscle contraction.

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