Overview of the Harvard
Catalyst
Imaging program- how to use
the resources for your research
Randy Gollub, MD,PhD
http://catalyst.harvard.edu
May 19, 2009
Harvard Catalyst: The History
and the Basics
• GCRC program (20+ yr NCRR/NIH funded
clinical research support program) discontinued
– MGH Biomedical Imaging Core established 2002
• CTSA 2007(Roadmap initiative)
• HU- Response-Harvard Catalyst
– (PI Lee Nadler/Co-Director: Steve Freedman)
• We are a pan-Harvard enterprise dedicated to
improving human health by:
– Creating Connections
– Enabling research At the Cutting Edge of discovery
– Nurturing clinical and translational researchers
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Imaging Consortium History
• MGH and BWH GCRC Imaging Cores
NCRR
– MGH and BWH P41s devoted to medical imaging
• Martinos Center for Functional Imaging Technologies (Rosen)
• Neuroimage Analysis Center (Kikinis)
• Image Guided Therapy (Jolesz)
– Biomedical Informatics Research Network (BIRN)
• Morphometry Testbed (Rosen)
• Functional Neuroimaging Testbed
NIH NCBC
– National Alliance for Medical Image Computing (NA-MIC)
Fee for Service (MGH/BWH/DFCC)
– DFCI Tumor Metrics Core
Institutions participating in Harvard CTSC
Yearly budget: $38 million (23 NIH + 15 matching)
Academic Healthcare Centers
• Beth Israel-Deaconess Medical
Center
• Brigham and Women’s Hospital
• Massachusetts General Hospital
• Children’s Hospital Boston
Specialty Hospitals and Institutes
• Dana-Farber Cancer Institute
• Forsyth Dental Institute
• Joslin Diabetes Center
• Massachusetts Eye and Ear
Infirmary
• McLean Hospital
• Schepens Eye Research Institute
Massachusetts Institutes of Technology
Blue –Imaging Consortium
Harvard University
• Faculty of Arts and Sciences
• Harvard Business School
• Harvard School of Dental Medicine
• Harvard Divinity School
• Graduate School of Design
• Graduate School of Education
• Kennedy School of Government
• Harvard Law School
• Harvard Medical School
• Harvard School of Public Health
• Harvard School of Engineering
Community Healthcare Institutions
• Cambridge Health Alliance
• HMS Department of Ambulatory
Care and Prevention at Harvard
Pilgrim Healthcare
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Harvard Catalyst
• Programs (Selected list)
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Translational Technologies (Imaging & Genetics)
Participant and Clinical Interactions Resource (PCIR)
Development of Novel C/T Methodologies
Biomedical Informatics
Pilot studies
Design and Biostatistics (Mark Vangel)
Research Education, Career Development
Diversity and Health Disparities Research
Ethics
Linkages across the institutions
Regulatory Knowledge and Support
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Imaging Consortium Team
Bruce Rosen, Director
Randy Gollub, Co-Director
Gordon J. Harris, Site Co-Director
Robert Lenkinski, Site Co-Director
Neil Rofsky, Site Co-Director
Clare Tempany, Site Co-Director
Ron Kikinis, Site Co-Director
Gordon Williams, PI for CTSC Translational Technologies
Stephan Voss, Site Co-Director
Simon Warfield, Site Co-Director
Annick D. Van den Abbeele, Site Co-Director
Jeff Yap, Site Co-Director
Gordon J. Harris, Site Co-Director
Annick D. Van den Abbeele, Site Co-Director
William Hanlon, Core Manager
Valerie Humblet, Imaging Liaison
Yong Gao, Imaging Informatics Architect
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Mission of the Imaging
Consortium
• Expand imaging in clinical research:
– Build & deploy infrastructure (expertise in single and
cross site image acquisition, image analysis,
visualization & data management software tools)
– Provide expert consultation in the use of imaging for
clinical translational research
– Educate and advise about available imaging and
image processing capabilities in the Harvard
environment
– Provide leadership & education at the local and
national level
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Harvard Catalyst website
http://catalyst.harvard.edu/home.html
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Image Consortium
Consultation Service
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Image Consortium
Consultation Service
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Technologies and Expertise
• Cancer imaging, MRI, PET, CT, fMRI, US,
pediatric imaging, neuroimaging.
• Focused on assisting with planning and design
of research proposals and/or methods for image
analysis.
• Consultation is available for the preparation of a
grant or IRB submission.
• We do not (yet) provide ongoing support for the
implementation of new studies or the analysis of
data from existing studies.
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Example of Imaging
Consultation
• Study of brain-development in premature infants
(new collaboration: CHB-BWH-MGH)
CHB: new Fetal-Neonatal Neuroimaging and
Developmental Science Center
Slicer (BWH): quantitative
tractography (Gilmore, 2007 AJNR)
Optical Imaging of Cerebral Oxygenation
in Infants (MGH)
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Pilot funds
• Eligibility:
All Harvard faculty are eligible to apply, regardless of
degree or institutional affiliation.
• First round: 62 projects funded (out of 602)
• Funds:
Pilot Grants will be awarded in the amount of $50,000,
with an award period of one year. (80 grants expected)
• Deadlines:
Letter of intent: May 13, 2009
Full application: June 12, 2009
• Contact:
Harvard Catalyst Research Navigators
617 432-7800
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MGH Biomedical Imaging Core
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MGH Biomedical Imaging Core
http://www2.massgeneral.org/crc/bic/index.ht
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MGH Biomedical Imaging Core
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MGH Biomedical Imaging Core
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MGH Biomedical Imaging Core
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TMS
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MGH Biomedical Imaging Core
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MGH BIC Imaging Engineers
Deployed cross site calibrated physiologic
monitoring systems for MRI at BWH, Children’s,
BIDMC, Harvard FAS and MIT
Catalyst created a community of biomedical engineers
w/ a shared focus on supporting C/T imaging
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MGH Biomedical Imaging Core
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MGH Biomedical Imaging Core
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MGH Biomedical Imaging Core
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MGH Biomedical Imaging Core
Coming in July 2009!
Webform PCIR application
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Medical Imaging Informatics
• Examples:
– Clinical:
• Ruling out appendicitis based on CT scans. Are
there metrics that can be found by analyzing
clinical data?
• Quantitative output from Freesurfer for Alzheimer
disease
– Research:
• Helping TIMC get easier access to PACS system
for clinical trials
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Medical Imaging Informatics
Secondary Use of Clinical Imaging Data
(Integration with i2b2)
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Standard T1 MRI scan
AUC 0.95 (specificity 91%,
sensitivity 90% to discriminate
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Medical Imaging Informatics
• IT Catalyst infrastructure:
– i2b2: scalable computational framework to help
translation of genomic findings.
– BIRN: XNAT imaging informatics platform: large
collections of images and study-specific metadata to
be managed by image-driven clinical translational
research groups.
– NA-MIC:robust, open source solutions for medical
image analysis, visualization and management
software tools by the creation of a “desktop” version
of XNAT. Key image analysis software tools: Slicer,
Freesurfer.
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Medical Imaging Informatics
Dr Z
Desktop
Chronic pain
management
Dr Y
Desktop
Alzheimer
Dr X
Desktop
Pediatric
rare disease
PACS
XNAT
Enterprise
Annotating
Genomic
Data #2
Project
Management
Natural
Language
Processing
Identity
Management
Data
Repository
(CRC)
Annotating
Genomic
Data #1
PACS
De Identification
Of data
File
Repository
Ontology
Management
Dr W
Desktop
Quantitative
cancer
biomarkers
Workflow
Framework
Correlation
Analysis
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i2b2 HIVE
Educational Program
• Mission: Provide lectures, tutorials, and educational
materials promoting the use of imaging to junior
investigators and associated research staff
• Tailored lectures: Host on-site and based on
discipline (oncology, neuro, cardiology, pediatrics,
etc)
• Generic imaging modules: Basic principles of
imaging, quantitative methods, clinical trial design
with imaging endpoints, imaging risks and
considerations for informed consent forms
• Dissemination: through national networks (CTSA,
RSNA, IRAT, SNM)
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National Effort in C/T
Research
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AHC/23
states
Mayo Clinic
Northwestern
UC Davis
Cornell
J.Hopkins
Duke
Emory U.
Wash. U.
Source: http://www.ctsaweb.org/
• Member of the NCRR Clinical and
Translational Science Award (CTSA)
Consortium-14 new in 08
• 14 Imaging programs-(Dan Sullivan/RSNA)
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http://catalyst.harvard.edu
Image_Consult@catalyst.harvard.edu
www.na-mic.org/Wiki/index.php/Collaboration:Harvard_CTSC
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