Blood and Hematopoiesis Quiz
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1. Reticulocytes may be identified by light microscopy
due to their containing basophilic remnants of
Amino acids
DNA
Lipids
RNA
Sugars
40%
33%
20%
7%
in
s
RN
A
id
s
Lip
DN
A
Su
ga
r
o
ac
id
s
0%
Am
A.
B.
C.
D.
E.
2. As the last step in neutrophilic
granulocytopoiesis,
g.
..
...
lic
op
hi
Eo
sin
on
ob
l
as
ts
at
ho
c
Or
t
M
hr
om
ll n
ce
di
v
op
.. .
.
uc
l..
...
E.
10%
3%
ul
D.
17%
14%
Ba
nd
C.
55%
en
-st
im
B.
Antigen-stimulated monocytes
differentiate into plasma cells
Band cell nuclei will begin to
become segmented
Orthochromatophylic
eryhtroblasts divide to form
reticulocytes
Monoblasts divide to form
lymphocytes
Eosinophilic granules are
produced
An
tig
A.
3. Hereditary spherocytosis is a condition which
involves a defect in a cytoskeletal protein of the
erythrocyte, causing an abnormal spherical cell shape.
This protein is
Albumin
Band 3 protein
Hemoglobin
Spectrin
P-selectin
94%
6%
in
le
ct
Pse
ct
r in
0%
Sp
e
og
l
ob
in
0%
He
m
Ba
nd
3
pr
ot
ei
n
um
in
0%
Al
b
A.
B.
C.
D.
E.
4. One function of the helper T lymphocytes is
to stimulate B lymphocytes to undergo mitosis
and subsequent differentiation into
Antibodies
Antigens
Cytotoxic cells
Natural killer cells
Plasma cells
77%
11%
lls
ce
sm
a
Pl
a
Na
t
ur
a
lk
ill
er
...
ce
ll.
..
en
s
Cy
to
to
xic
An
tig
s
od
ie
8%
4%
0%
An
tib
A.
B.
C.
D.
E.
5. The predominant component(s) of blood
plasma, making up roughly 90% of its weight
is/are
Albumin
Neutrophils
Protein
Solutes
Water
84%
14%
er
W
at
ut
e
s
0%
So
l
in
0%
Pr
ot
e
ph
i
tro
Ne
u
um
in
ls
2%
Al
b
A.
B.
C.
D.
E.
6. The predominant protein(s) in blood plasma
is/are
Albumins
Fibrinogens
Globulins
Hemoglobin
Red blood cells
94%
0%
od
bl
o
d
Re
He
m
og
l
ce
ll.
..
ob
in
s
lin
Gl
ob
u
Fib
r in
og
e
ns
s
in
um
4%
2%
0%
Al
b
A.
B.
C.
D.
E.
7. The predominant cell type(s) in blood is/are
Leukocytes
Lymphocytes
Neutrophils
Platelets
Red blood cells
85%
7%
6%
ce
ll.
..
le
ts
te
Re
d
bl
o
od
Pl
a
Ne
u
tro
ph
i
ls
es
0%
ph
oc
yt
Ly
m
oc
y
te
s
2%
Le
uk
A.
B.
C.
D.
E.
8. The predominant leukocytic cell type in blood
is/are
Basophils
Lymphocytes
Monocytes
Neutrophils
T cells
94%
el
ls
ph
i
tro
Ne
u
ls
0%
te
s
on
oc
y
M
Ly
m
ph
oc
yt
es
ils
2%
Tc
4%
0%
Ba
so
ph
A.
B.
C.
D.
E.
9. The agranulocyte lineage of leukocytes
contains the lymphocytes and what other
cell type?
Erythrocytes
Macrophages
Megakaryocytes
Monocytes
Neutrophils
72%
12% 12%
M
Ne
u
tro
ph
i
ls
te
s
0%
on
oc
y
M
eg
ak
ar
yo
cy
te
s
ge
s
ph
a
M
ac
ro
th
r
oc
yt
es
5%
Er
y
A.
B.
C.
D.
E.
10. Senescence of red blood cells is a process in which aged cells
are destroyed by macrophages. The Band 3 protein involved in
this process is actually a type of
A. Chloride channel
B. Cytoskeletal
filament
C. Platelet
D. Stereocilia
E. Tight junction
72%
16%
6%
6%
tio
n
ia
ju
nc
oc
il
Ti
gh
t
re
St
e
te
le
t
Pl
a
le
ta
lf
.. .
Cy
to
sk
e
Ch
l
or
id
e
ch
an
n.
..
0%
11. What is the most common human hemoglobin
type?
88%
11%
0%
Hb
S
0%
Hb
H
Hb
F
2%
Hb
A2
HbA
HbA2
HbF
HbH
HbS
Hb
A
A.
B.
C.
D.
E.
12. Erythrocyte senesence ultimately leads to destruction by
macrophages predominantly in which organ ?
Liver
Lymph nodes
Spleen
Thymus
Yellow bone
marrow
85%
13%
Ye
llo
m
a.
..
0%
bo
ne
w
Th
ym
us
ee
n
0%
Sp
l
no
de
s
Ly
m
ph
er
2%
Liv
A.
B.
C.
D.
E.
13. The typical lifespan of a circulating erythrocyte is
1-2 hours
2 days
120 days
2 weeks
2 years
78%
11%
5%
5%
rs
ea
2y
ee
ks
2w
s
da
y
12
0
ay
s
2d
ho
ur
s
0%
12
A.
B.
C.
D.
E.
13. Of the 4 common, human blood types, Type O is
unique in that an individual possesses red blood cells
with no A or B antigens and
A. Both A and B
antibodies
B. No A or B antibodies
C. Only A antibodies
D. Only B antibodies
E. Only C antibodies
83%
15%
0%
2%
s
an
t ib
od
On
ie
ly
s
C
an
tib
od
ie
s
od
ie
yB
yA
On
l
an
tib
od
i
tib
On
l
A
No
Bo
th
A
an
d
B
or
B
an
an
tib
od
ie
s
es
0%
15. Neutrophils are motile cells. Microtubules play an important
role in this locomotion ability along with
A. Actin and myosin
B. Large cell size
C. Non-staining
granules
D. Prolonged lifespan
E. Segmentation of
their nuclei
88%
2%
6%
o.
..
..
0%
n
tio
en
ta
m
Se
g
ng
ed
lif
e.
...
Pr
ol
o
ng
g
No
ns
ta
i
ni
ll s
ce
ge
La
r
Ac
t
in
an
d
m
yo
s..
.
iz.
..
4%
16. Eosinophil specific granules stain eosinophilic giving the cell
its characteristic red color. The predominant protein in the
eosinophil specific granule is
Collagen
Collagenase
Hemoglobin
Keratin
Major basic protein
62%
19%
13%
pr
...
t in
aj
or
ba
sic
M
Ke
ra
ob
in
2%
og
l
He
m
Co
l
lag
lag
en
a
en
se
4%
Co
l
A.
B.
C.
D.
E.
17. Basophils are functionally similar to mast cells in that they
secrete granules containing similar protein content, notably
A. Antibodies
B. Collagenase
C. Heparin and
Histamine
D. Major basic protein
E. P-selectin
94%
Hi
st
an
d
in
He
pa
r
in
le
ct
en
lag
Co
l
Pse
s
od
ie
An
tib
2%
0%
am
M
aj
in
or
e
ba
sic
pr
ot
ei
n
2%
as
e
2%
18. Humoral immunity is mediated by B cells which upon
activation by antigen recognition differentiate into a cell capable
of producing antibodies, the
B cell
Macrophage
Natural Killer cell
Plasma cell
T cell
68%
15%
a
sm
Pl
a
el
l
ll
ce
...
er
lK
ur
a
Na
t
ac
ro
M
5%
ill
ph
a
ce
ge
ll
5%
Tc
7%
B
A.
B.
C.
D.
E.
19. Cell-mediated immunity is a function of many cells including
T cells. A T cell which directly acts to kill cells expressing foreign
antigens on their surface is termed
83%
8%
es
so
r
ur
a
l
0%
Na
t
M
em
or
y
2%
Su
pp
r
8%
He
lp
er
Cytotoxic
Helper
Memory
Natural
Suppressor
Cy
to
to
xic
A.
B.
C.
D.
E.
20. Memory B cells derive from a naïve B cells initial exposure to
a foreign antigen. What is true of the immune response of a
memory B cell after a second exposure to that antigen?
It doesn’t occur
It involves the CNS
It is larger in scope
It is slower
It is smaller
91%
6%
le
r
al
ss
m
It
i
It
i
ss
lo
w
i. .
.
ar
sl
It
i
0%
er
0%
ge
r
th
. ..
ve
s
nv
ol
It
i
oe
s
n’
to
cc
...
3%
It
d
A.
B.
C.
D.
E.
21. Platelets are cell fragments that derive from
which cell type?
Megakaryocytes
Monocytes
Osteocytes
Plasma cells
T lymphocytes
94%
a
sm
Pl
a
ym
ph
oc
y
Tl
s
cy
te
2%
te
s
0%
ce
lls
0%
Os
te
o
te
s
on
oc
y
M
eg
ak
ar
yo
cy
te
s
4%
M
A.
B.
C.
D.
E.
22. Platelets contain structures called granulomeres that contain
numerous proteins. A key protein in the granulomere is a growth
factor important in blood vessel growth and regeneration, and is
named
56%
20%
12%
Pe
rfo
t in
le
c
Pse
rin
7%
5%
M
aj
or
hi
st
Le
oc
ct
Pl
o
in
at
m
el
p
at
et
ib
-d
ili
er
t..
iv
.
ed
gr
ow
th
...
A. Leptin
B. Major
histocompatibility
complex
C. Platelet-derived
growth factor
D. P-selectin
E. Perforin
23. Platelets possess contractile activity, and play an important
role in repairs to blood vessels. This contractile activity in
platelets is mediated in part by
A. Actin and myosin
B. Demarcation
membranes
C. Granulomeres
D. Megakaryocytopoiesis
E. Smooth muscle
71%
17%
7%
M
us
c le
m
...
Sm
oo
th
eg
ak
ar
yo
cy
to
p
er
e
s
0%
lo
m
e.
Gr
an
u
m
n
tio
De
m
ar
ca
Ac
t
in
an
d
m
yo
s..
.
..
5%
24. Inactive marrow that functions primarily to
store fat is termed
Multilocular
Red
Unilocular
White
Yellow
89%
w
lo
Ye
l
te
r
lo
cu
la
d
Re
6%
W
hi
6%
0%
Un
i
ul
ti
lo
cu
la
r
0%
M
A.
B.
C.
D.
E.
25. Colony stimulating factors (CSFs) are compounds which influence
hematopoiesis and promote the production of specific cell types. One key
example, GM-CSF, when released, could lead to the increased production of
which of the following cell types?
A. B lymphocytes
B. Basophils, eosinophils,
neutrophils, monocytes
C. Erythrocytes
D. Megakaryocytes
E. T lymphocytes
64%
11% 11%
8%
te
s
ym
ph
oc
y
cy
te
s
Tl
M
eg
ak
th
r
Er
y
ar
yo
oc
yt
es
os
...
ils
,e
te
s
Ba
so
ph
m
ph
oc
y
ly
B
6%
26. Hematopoietic growth factors direct the production of cell types in the
bone marrow. Erythropoietin, a factor produced by the kidney increases the
production of which cell type?
B lymphocytes
Basophils
Erythrocytes
Megakaryocytes
T lymphocytes
95%
te
s
0%
ym
ph
oc
y
cy
te
s
Tl
M
eg
ak
ar
yo
oc
yt
es
0%
th
r
Ba
so
ph
ils
2%
Er
y
ly
m
ph
oc
y
te
s
3%
B
A.
B.
C.
D.
E.
27. Colony forming units (CFUs) are groups of cells which have committed to a
common lineage in hematopoiesis. CFU-Ly defines cells which have
committed to the lymphocyte lineage. Which common colony forming unit is
responsible for the formation of granulocytes, monocytes, erythrocytes, and
megakaryocytes?
CFU-E
CFU-GEMM
CFU-GM
CFU-Ly
CFU-Meg
17%
M
eg
3%
CF
U-
Ly
CF
U-
GM
CF
U-
GE
M
M
0%
CF
U-
E
0%
CF
U-
A.
B.
C.
D.
E.
80%
28. The bone marrow stroma is composed of adventitial cells which form a
reticular network to support the marrow tissue and hematopoietic cell
network. Hematopoietic cells bind to this network through a marrow-specific
adhesion protein called
A. Colony stimulating
factor
B. Hemonectin
C. Heparin
D. Lymphokine
E. P-selectin
50%
29%
11%
11%
Co
l
in
Pse
le
ct
e
Ly
m
ph
ok
in
in
He
pa
r
ct
in
He
m
on
e
on
y
st
im
ul
a
. ..
0%
29. Examination of a normal peripheral blood smear reveals a cell more than
twice the diameter of an erythrocyte with a kidney-shaped nucleus. These
cells were <10% of total leukocytes. Which of the following cell types is being
described?
Basophil
Eosinophil
Lymphocyte
Monocyte
Neutrophil
65%
26%
6%
ph
i
tro
Ne
u
on
oc
y
M
ph
oc
yt
l
te
2%
e
l
Ly
m
op
hi
Eo
sin
il
2%
Ba
so
ph
A.
B.
C.
D.
E.
30. Basophils, neutrophils, and eosinophils differentiate through
a final common granulocytic precursor cell termed the
Erythroblast
Lymphoblast
Platelet
Promyelocyte
Unilocular adipocyte
81%
15%
...
0%
lo
cu
la
Un
i
Pr
om
ye
lo
ra
di
cy
te
t
te
le
Pl
a
st
0%
ph
ob
la
Ly
m
th
r
ob
l
as
t
4%
Er
y
A.
B.
C.
D.
E.
31. In the pathway of erythrocytopoiesis, the final defined
precursor cell before the formation of a mature erythrocyte is
called a
Erythroblast
Myeloblast
Platelet
Reticulocyte
T cell
tic
ul
o
Re
el
l
0%
Tc
0%
cy
te
le
t
0%
te
st
0%
M
ye
lo
bl
a
Er
y
:30
th
r
ob
l
as
t
0%
Pl
a
A.
B.
C.
D.
E.
32. The neutrophil is considered to ‘reside’ in several theoretical
compartments during its development and lifespan. From its circulation in the
bloodstream the neutrophil is able to migrate into connective tissue spaces
upon binding a key endothelial cell adhesion molecule called
IgE antibody
Collagenase
Hemonectin
Major binding protein
P-selectin
le
ct
Pse
g.
..
di
n
0%
in
0%
aj
or
bi
n
M
Co
l
lag
en
y
an
t ib
od
IgE
:30
0%
ct
in
0%
as
e
0%
He
m
on
e
A.
B.
C.
D.
E.
33. When a blood vessel is damaged a coordinated sequence of events
involving many cell types and proteins takes place. One of the initial steps is
the aggregation of platelets to form a platelet plug at the site of the damage
where collagen from connective tissue is exposed to the blood. The
aggregation at this site is possible due to the platelets having
IgE antibody
Collagenase
Hemonectin
Major binding protein
Sticky glycoprotein coat
gl
co
te
in
yc
o
pr
o
di
n
St
ick
y
0%
at
te
in
0%
gp
ro
on
e
ct
in
0%
aj
or
bi
n
He
m
lag
en
y
Co
l
an
t ib
od
IgE
:30
0%
as
e
0%
M
A.
B.
C.
D.
E.
34. Identify this cell (arrow, black).
Basophil
Eosinophil
Lymphocyte
Monocyte
Neutrophil
0%
0%
l
ph
i
tro
Ne
u
M
on
oc
y
e
te
0%
ph
oc
yt
op
hi
l
Ly
m
:30
0%
Eo
sin
il
0%
Ba
so
ph
A.
B.
C.
D.
E.
35. Identify this cell (arrow, black).
Basophil
Eosinophil
Lymphocyte
Monocyte
Neutrophil
0%
0%
l
ph
i
tro
Ne
u
M
on
oc
y
e
te
0%
ph
oc
yt
op
hi
l
Ly
m
:30
0%
Eo
sin
il
0%
Ba
so
ph
A.
B.
C.
D.
E.
36. Identify this cell (arrow, black).
Basophil
Eosinophil
Lymphocyte
Monocyte
Neutrophil
0%
0%
l
ph
i
tro
Ne
u
M
on
oc
y
e
te
0%
ph
oc
yt
op
hi
l
Ly
m
:30
0%
Eo
sin
il
0%
Ba
so
ph
A.
B.
C.
D.
E.
37. Identify these structures (arrows, black).
Cellular debris
Erythrocytes
Platelets
Processing artifact
Reticulocytes
s
0%
cy
te
tic
ul
o
Re
ss
in
g
le
te
0%
ar
t..
.
ts
0%
Pl
a
th
r
oc
yt
es
0%
Pr
oc
e
:30
Er
y
lar
de
b
r i.
..
0%
Ce
llu
A.
B.
C.
D.
E.
38. Identify this cell (arrow, black).
Basophil
Eosinophil
Lymphocyte
Monocyte
Neutrophil
0%
0%
l
ph
i
tro
Ne
u
M
on
oc
y
e
te
0%
ph
oc
yt
op
hi
l
Ly
m
:30
0%
Eo
sin
il
0%
Ba
so
ph
A.
B.
C.
D.
E.
39. Identify this cell (arrow, black).
Basophil
Eosinophil
Lymphocyte
Monocyte
Neutrophil
0%
0%
l
ph
i
tro
Ne
u
M
on
oc
y
e
te
0%
ph
oc
yt
op
hi
l
Ly
m
:30
0%
Eo
sin
il
0%
Ba
so
ph
A.
B.
C.
D.
E.
40. Identify this cell (arrow, black).
Basophil
Eosinophil
Lymphocyte
Monocyte
Neutrophil
0%
0%
l
ph
i
tro
Ne
u
M
on
oc
y
e
te
0%
ph
oc
yt
op
hi
l
Ly
m
:30
0%
Eo
sin
il
0%
Ba
so
ph
A.
B.
C.
D.
E.
41. Identify this cell (arrow, black).
Basophil
Eosinophil
Lymphocyte
Monocyte
Neutrophil
0%
0%
l
ph
i
tro
Ne
u
M
on
oc
y
e
te
0%
ph
oc
yt
op
hi
l
Ly
m
:30
0%
Eo
sin
il
0%
Ba
so
ph
A.
B.
C.
D.
E.
42. Identify this cell (arrow, black).
Basophil
Eosinophil
Lymphocyte
Monocyte
Neutrophil
0%
0%
l
ph
i
tro
Ne
u
M
on
oc
y
e
te
0%
ph
oc
yt
op
hi
l
Ly
m
:30
0%
Eo
sin
il
0%
Ba
so
ph
A.
B.
C.
D.
E.
43. Identify this cell (arrow, black).
Basophil
Eosinophil
Lymphocyte
Monocyte
Neutrophil
0%
0%
l
ph
i
tro
Ne
u
M
on
oc
y
e
te
0%
ph
oc
yt
op
hi
l
Ly
m
:30
0%
Eo
sin
il
0%
Ba
so
ph
A.
B.
C.
D.
E.
44. Identify this cell (arrow, black).
Basophil
Eosinophil
Lymphocyte
Monocyte
Neutrophil
0%
0%
l
ph
i
tro
Ne
u
M
on
oc
y
e
te
0%
ph
oc
yt
op
hi
l
Ly
m
:30
0%
Eo
sin
il
0%
Ba
so
ph
A.
B.
C.
D.
E.
45. Identify this cell (arrow, black).
B lymphocyte
Eosinophil
Megakaryocyte
Monocyte
Neutrophil
0%
l
ph
i
tro
Ne
u
on
oc
y
te
0%
M
cy
te
0%
ar
yo
eg
ak
Eo
sin
op
hi
l
0%
M
:30
ly
m
ph
oc
y
te
0%
B
A.
B.
C.
D.
E.
46. Identify this structure (arrow, black).
Eosinophil
Lymphatic vessel
Megakaryocyte
Sinusoid
T lymphocyte
te
0%
ym
ph
oc
y
us
oi
d
Tl
eg
ak
0%
Sin
cy
te
0%
ar
yo
ic
ve
s
se
l
0%
M
Ly
m
:30
ph
at
op
hi
l
0%
Eo
sin
A.
B.
C.
D.
E.
47. Identify these cells (arrows, black).
Adipocytes
Erythrocytes
Lymphocytes
Megakaryocytes
Monocytes
on
oc
y
te
s
0%
M
ar
yo
eg
ak
M
0%
cy
te
s
es
0%
ph
oc
yt
Ly
m
Er
y
th
r
yt
e
po
c
:30
0%
oc
yt
es
s
0%
Ad
i
A.
B.
C.
D.
E.
48. Identify these cells (arrows, black).
B lymphocytes
Eosinophils
Megakaryocytes
Monocytes
Neutrophils
0%
Ne
u
tro
ph
i
ls
te
s
0%
on
oc
y
M
cy
te
s
0%
ar
yo
eg
ak
Eo
sin
op
hi
ls
0%
M
:30
ly
m
ph
oc
y
te
s
0%
B
A.
B.
C.
D.
E.
49. Identify these structures (arrows, black).
Eosinophils
Lymphatic vessels
Megakaryocytes
Sinusoids
Woven bone
bo
ne
0%
W
ov
en
us
oi
d
Sin
ar
yo
0%
s
0%
cy
te
s
s..
.
eg
ak
M
ph
at
Ly
m
:30
0%
ic
ve
s
op
hi
ls
0%
Eo
sin
A.
B.
C.
D.
E.
50. In this image of a bone marrow smear, the indicated cells
belong to which hematopoietic lineage (arrows, black)?
B lymphocyte
Erythroid
Lymphoid
Monocytic
Myeloid
d
tic
on
oc
y
0%
M
ye
lo
i
0%
M
ph
oi
Ly
m
oi
d
th
r
Er
y
m
ph
oc
y
ly
:30
0%
d
0%
te
0%
B
A.
B.
C.
D.
E.
51. Your patient is suffering from an infestation of parasites. To determine the
proper therapy, you perform an analysis of a peripheral blood sample. Which
of the following cells would you expect to be increased in a peripheral blood
smear?
Basophils
Eosinophils
Lymphocytes
Monocytes
Neutrophils
0%
0%
ls
ph
i
tro
Ne
u
M
on
oc
y
es
te
s
0%
ph
oc
yt
op
hi
ls
0%
Eo
sin
:30
Ba
so
ph
ils
0%
Ly
m
A.
B.
C.
D.
E.
52. A decrease in the number of tissue macrophages
would result from reduced activity of precursor cells to
which of the following cell types?
Basophils
Erythrocytes
Monocytes
Neutrophils
Megakaryocytes
0%
ph
i
eg
ak
ar
yo
tro
Ne
u
0%
cy
te
s
ls
te
s
0%
on
oc
y
th
r
oc
yt
es
0%
M
:30
Er
y
Ba
so
ph
ils
0%
M
A.
B.
C.
D.
E.
53. Which of the following cells is the primary
phagocytic cell within peripheral blood?
Basophil
Eosinophil
Lymphocyte
Monocyte
Neutrophil
0%
0%
l
ph
i
tro
Ne
u
M
on
oc
y
e
te
0%
ph
oc
yt
op
hi
l
0%
Eo
sin
:30
Ba
so
ph
il
0%
Ly
m
A.
B.
C.
D.
E.
54. Pernicious anemia develops as a consequence of
which of the following?
t..
.
as
ed
pl
a
as
ed
0%
sy
nt
...
0%
n
De
cr
e
as
ed
le
as
ed
iro
ve
.
...
ch
a
De
cr
e
id
ac
o
in
Am
:30
0%
De
cr
e
0%
..
0%
De
cr
e
A. Amino acid change of
the globin moecule
B. Decreased levels of
intrinsic factor
C. Decreased iron
D. Decreased platelets
E. Decreased synthesis of
hemoglobins
55. While examining a peripheral blood smear, you notice an increased
number of cells slightly larger than an erythrocyte. These cells have a large,
round nucleus and scant cytoplasm. Which of the following would cause this
condition?
A. Bacterial infection
B. Hemorrhage
C. Organ transplant
rejection
D. Parasitic infection
E. Pollen infestation
in
fe
sta
.
..
0%
n
le
Po
l
as
iti
Pa
r
ns
pl
a
tra
an
0%
ci
.. .
e
ha
g
Or
g
He
m
or
r
nf
e.
li
er
ia
Ba
ct
:30
0%
nf
e.
..
0%
..
0%
56. A young man complains that he bruises easily. A laboratory report showed
a normal white cell count. Erythrocytes were 5 million/mm3, whereas
platelets were 50,000/mm3. Which of the following was the diagnosis?
Hemophilia
Pernicious anemia
Polycytothemia
Thalassemia
Thrombocytopenia
0%
cy
to
p
en
. ..
ia
0%
as
se
m
Th
al
m
ia
0%
to
th
e
yc
y
ou
sa
ne
...
0%
Th
ro
m
bo
:30
Pe
rn
ic i
He
m
op
h
ilia
0%
Po
l
A.
B.
C.
D.
E.
57. Which of the following blood cells differentiate
outside of the bone marrow?
Basophils
Eosinophils
Megakaryocytes
Neutrophils
T lymphocytes
0%
te
s
0%
ym
ph
oc
y
Tl
Ne
u
tro
ph
i
ls
0%
cy
te
s
ls
eg
ak
op
hi
M
:30
0%
Eo
sin
Ba
so
ph
ils
0%
ar
yo
A.
B.
C.
D.
E.
58. An analysis of a peripheral blood smear showed that
reticulocytes were 10% of total cells. Which of the following
represents the proper diagnosis?
A. Cell-mediated immune
response
B. Hemorrhage
C. Humoral-mediated
immune response
D. Infection
E. Myelocytic leukemia
le
u.
..
0%
yt
ic
oc
ye
l
M
ed
alm
or
0%
In
fe
ct
io
n
t. .
.
0%
ia
ha
g
Hu
m
He
m
or
r
ed
ed
iat
Ce
llm
:30
0%
e
.. .
0%
59. Which of the following is not derived by a mitotic
division of a precursor cell?
A. Monocyte
B. Osteoblast
C. Polychromatophilic
erythroblast
D. Platelet
E. Proerythroblast
0%
0%
as
...
ob
l
Pr
oe
ry
th
r
Pl
a
te
le
t
0%
ro
m
at
op
h.
..
as
t
bl
yc
h
Po
l
:30
0%
Os
te
o
M
on
oc
y
te
0%
60. Examining a peripheral blood smear, you note a cell type that consists of
both large and small cells intermixed with normal size cells, a condition
described as anisocytosis. This abnormal condition refers to which of the
following?
Basophils
Erythrocytes
Lymphocytes
Monocytes
Platelets
M
te
le
Pl
a
on
oc
y
es
0%
ts
0%
te
s
0%
ph
oc
yt
oc
yt
es
0%
th
r
Er
y
:30
Ba
so
ph
ils
0%
Ly
m
A.
B.
C.
D.
E.
61. Your patient suffers from a blood disorder that requires chemotherapy. A
bone marrow transplant is subsequently performed. Transplants containing
which of the following cells in the erythrocytic series would not provide
proliferative cells?
A. Basophilic erythroblast
B. Hematopoietic stem
cell
C. Orthochromatophilic
erythroblast
D. Polychromatophilic
erythroblast
E. Proerythroblast
ilic
Ba
so
ph
:30
0%
0%
0%
0%
er
y.
He
..
m
at
op
oi
et
Or
ic
th
...
oc
hr
om
at
op
Po
.. .
lyc
hr
om
at
op
h.
Pr
..
oe
ry
th
ro
bl
as
...
0%
62. At which of the following stages are specific cells of
the granulocytic series first recognizable?
A. Hematopoietic stem
cell
B. Metamyelocyte
C. Myeloblast
D. Myelocyte
E. Promyelocyte
0%
0%
cy
te
lo
ye
Pr
om
M
ye
l
oc
bl
a
yt
e
st
0%
ye
lo
M
lo
cy
M
et
am
ye
et
ic
He
m
at
op
oi
:30
0%
te
...
0%
63. Hemoglobin is first seen in which of the following
cells of the erythrocytic series?
A. Basophilic erythroblast
B. Orthochromatophilic
erythroblast
C. Polychromatophilic
erythroblast
D. Proerythroblast
E. Reticulocyte
0%
0%
0%
0%
ro
lic
m
er
at
...
op
hi
lic
er
yt
.. .
Pr
oe
ry
th
ro
bl
as
t
Re
tic
ul
oc
yt
e
op
hi
Po
l
yc
h
hr
om
at
ho
c
:30
Or
t
Ba
so
ph
ilic
er
yt
hr
ob
l
as
t
0%
64. In which of the following cells of the erythrocytic
series is the nucleus extruded?
A. Basophilic erythroblast
B. Orthochromatophilic
erythroblast
C. Polychromatophilic
erythroblast
D. Proerythroblast
E. Reticulocyte
0%
0%
0%
0%
ro
lic
m
er
at
...
op
hi
lic
er
yt
.. .
Pr
oe
ry
th
ro
bl
as
t
Re
tic
ul
oc
yt
e
op
hi
Po
l
yc
h
hr
om
at
ho
c
:30
Or
t
Ba
so
ph
ilic
er
yt
hr
ob
l
as
t
0%
65. While examining cells of a bone marrow smear with the light microscope,
you notice a cell whose cytoplasm has no noticeable granules. The nucleus of
this cell in indented and contains no nucleoli. Which of the following cells are
you examining?
A. Basophilic erythroblast
B. Myelocyte
C. Neutrophilic
metamyelocyte
D. Polychromatophilic
erythroblast
E. Promyelocyte
m
...
lic
yc
h
Po
l
0%
0%
ro
m
at
op
h.
..
Pr
om
ye
lo
cy
te
0%
ph
i
M
ye
lo
cy
te
0%
Ne
ut
ro
:30
Ba
so
ph
ilic
er
y.
..
0%
66. Which of the following best characterizes bone
marrow?
0%
m
u.
..
Ye
llo
w
bo
ne
te
sm
at
m
on
oc
y
M
0%
a.
..
0%
es
n
ct
io
De
st
ru
od
bl
o
:30
0%
a.
..
0%
Al
l
E.
ce
ll.
..
D.
of
...
C.
ph
oc
yt
B.
All blood cells undergo
maturation within the bone
marrow
Destruction of erythrocytes is
carried out in red bone marrow
Lymphocytes mature in bone
marrow
Monocytes mature in bone
marrow
Yellow bone marrow does not
function to produce blood cells
Ly
m
A.
67. A sample of peripheral blood from a patient reveals a larger than normal
population of cells that have large, round nuclei with 1 or 2 nucleoli. The
cytoplasm of these cells shows azurophilic granules. Which of the following
forms of leukemia would you suspect?
Basophilic leukemia
Eosinophilic leukemia
Lymphoblastic leukemia
Promyelocytic leukemia
Stem cell leukemia
uk
...
0%
ce
ll
le
...
St
em
Ly
m
0%
lo
cy
tic
st
ic
. ..
0%
ph
ob
la
lic
l..
.
0%
op
hi
Eo
sin
:30
Ba
so
ph
ilic
le
u.
..
0%
Pr
om
ye
A.
B.
C.
D.
E.
68. A peripheral blood smear of a person suffering from a mild
form of leukemia showed a large number of cells with more than
1 nucleolus. Which of the following cells is being described?
op
.. .
yc
h
at
Po
l
hr
om
ho
c
0%
ro
m
at
op
h.
..
0%
m
...
lic
Ne
u
tro
ph
i
tro
Ne
u
0%
ph
i
lic
bl
a
ye
lo
M
:30
0%
m
...
st
0%
Or
t
A. Myeloblast
B. Neutrophilic
metamyelocyte
C. Neutrophilic myelocyte
D. Orthochromatophilic
erythroblast
E. Polychromatophilic
erythroblast
69. Your patient suffers from lymphocytic leukemia. Chemotherapy is
administered to destroy cancerous cells of the bone marrow. Precursor cells
to erythrocytes are destroyed. To specifically re-establish the erythrocytic cell
line, which of the following cells should be transplanted?
A.
B.
C.
D.
Basophilic erythroblasts
Megakaryoblasts
Metamyelocytes
Orthochromatophilic
erythroblasts
E. Reticulocytes
Or
t
s
0%
Re
tic
ul
o
op
.. .
at
ho
c
hr
om
lo
cy
ye
et
am
M
0%
cy
te
0%
te
s
st
...
0%
bl
a
ar
yo
M
eg
ak
:30
Ba
so
ph
ilic
er
y.
..
0%
70. As cells undergo the process of erythropoiesis,
which of the following occurs?
A. Chromatin becomes more
diffuse
B. Nuclei become lobulated
C. Nuclei decrease in size
D. Nucleoli increase in number
E. Rough endoplasmic
reticulum increases within
the cytoplasm
en
do
pl
Ro
ug
h
ii
ol
Nu
cle
0%
as
.. .
0%
nc
re
...
as
. ..
0%
ec
re
id
Nu
cle
ec
om
e
o.
..
be
c
Nu
cle
ib
at
in
Ch
ro
m
:30
0%
...
0%