Name:_______________
with the Romanov’s
You are about to embark on a cyber-journey! Follow these directions
step-by-step in order to successfully answer the boxed questions.
1. Log on to your computer and click your Internet Browser
(Internet Explorer, Safari, Mozilla Firefox, etc.)
2. Type in the following web address:
http://www.dnai.org/
3. Click on the section called Applications
4. Click on the section called Recovering the Romanovs
5. Read this section
6. Click on the section the Romanov Family
7. Then click START located on the picture.
8. Read the 1st section titled Alexandra and Nicolas and answer the
following question.
From the three-person pedigree located on this page, what does
a square and a circle mean?
SquareCircleWhat does the horizontal line symbolize?
What does the vertical line symbolize?
9. Click on the small bubbled 2 located towards the bottom of the page.
Briefly read over this section.
10.
Click on the small bubbled 3 located towards the bottom of the
page. Briefly read over this section.
11.
Next, click on the small bubbled 4 located towards the bottom of
the page. Carefully read over this section and answer the following
question.
What is the red in the square and circle symbolize?
12.
On this page, click on the LINKS tab in grey and go to the link for
Sex-linked Disorder.
13.
Go to the Animation and read through each screen of the
animation. You move from one screen to the next by clicking the right
and left arrows at the bottom right.
14.
Stop reading when Charles Davenport introduces himself and
answer the following questions.
Key:
H=normal allele h=hemophilia allele, X=X chromosome Y=Y chromosome

Use a Punnett square to show the cross between Tsar Nicolas
and Alexandra.
o What is the percent chance that one of their children
would have the disorder?
o What is the percent chance that only a son would have
the disorder?
o What is the percent chance that a daughter would be a
carrier of the disorder?
o How is it possible for a family with the same genotypes
as the Tsar and Tsarina to have no children with
hemophilia?
*You are now done with this portion of the Webquest. You may X out of these
WebPages and log off your computer. Now, refer to the Follow-Up Questions.
Follow-Up Questions:
1. How is hemophilia inherited?
2. How does this mechanism work?
3. What value did you receive from the pedigree analysis?
4. If you were a genetic counselor, how would you use pedigrees?