Name Date Period Student Note Guide I. Sex Determination in _________________ A. General Information 1._________ chromosomes come from Mom 2.__________ chromosomes come from Dad 3. 23rd pair of chrs. Is______________________ 4. 23rd pair of chrs. Is ______________________ ★Total # of chrs. In normal human = _________________ Autosomes = _______________________ Sex Chromosomes = _________________ B. Details of Sex determination 1. Having a Y chr. _____________________ 2. Absence ____________________________ 3. ♂s make ______________________ 4. If_________ sperm fertilizes egg, then _________child 5. If _________sperm fertilizes egg, then _________ child Draw the diagram Here ★Therefore________________ determines the sex of the child II. Pedigrees A. = diagram showing the inheritance of a certain gene through several generations B. Symbols ♀ = _______________ Draw the diagram Here ♂ = ________________ 1 III. ___________________________ A. Usually found on _____________________ B. Affects _____________more than ____________________ C. Females can be_____________________, & not have the disorder (but can_______________________) D. Examples: ______________________and _____________________________ IV. Hemophilia A. Background Facts 1. ____________________________ 2. Caused by ________________________ 3. Slight ______________________________can be fatal 4. __________________________sex-linked genetic disease 5. Info. on _______________chromosome (no info.________________) V. History of Hemophilia One of Victoria’s Secrets… A. Queen Victoria of England was a ________________________________ B. Queen Victoria’s descendants C.________________________________, son of Tsar Nicolas II One of the most famous hemophiliacs was Russian Prince Tsarevitch Alexei, killed along with all his family during the_____________________________________ . 2 VI. Treatment of Hemophilia A. _________________________________________ B. Danger: VII. Hemophilia problem • Alice is a ____________________________ • Her ____________________does not have the disorder. • Can their children have the disorder? • Let’s use a ___________________ square to determine the probabilities. Xh =______________ X = ______________ Y = ____ Draw Punnett Here 3