Principles of Immunology (MICR 801) ‐ Fall, 2014 A. Contact Information B. Michael Parmely, Ph.D. 3003 Hixon 588‐7053 mparmely@kumc.edu Intended Course Outcomes: Participants who have completed this course will be able to: 1. Apply a broad understanding of the cellular and molecular basis for immune responses to a variety of biomedical research and healthcare problems. 2. Describe the nature of immune cell differentiation and the activation of immune cells by foreign antigens or patterns as well as the mechanisms of immune effector functions. 3. Apply an understanding of the immune system to the pathogenesis of immune‐based diseases. 4. Design experimental approaches to studying basic immunological research problems and the health‐related contexts in which the immune system fails to function properly. C. Schedule of Sessions 9:00 – 10:30 AM, Tuesdays and Thursdays Room 1007 Orr‐Major Session Date Title
Readings from Readings from th
Kuby 6 Edition Kuby 7th Edition 1 2 Tues, August Immune system overview
26 Thurs, August 28 Innate immunity
Ch 1, 2
Ch 1, 2
Ch3
Ch 5
Ch 4, 5, 6
Ch 3, 7, 20
3 Tues, Sept 2 Antigen recognition
4 Thurs, Sept 4 T cells, HMC and immune repertoire Ch 8, 9
Ch 7, 8
5 Tues, Sept 9 Lymphocyte development and activation Ch 10, 11, 12
Ch 9, 10, 11, 12
6 Thurs, Sept 11 Immune effector mechanisms
Ch 7, 13, 14
Ch 6, 13
7 Tues, Sept 16 Immune tissue injury
Ch 15
Ch 15
8 Thurs, Sept 18 Immune tolerance and autoimmunity Ch 16
Ch 16
9 Tues, Sept 23 Transplantation and tumor immunology Ch 17, 21
Ch 16, 19
10 Thurs, Sept 25 Immune responses to microbes Ch 18, 19
Ch 17
* You should occasionally consult chapter 22 for experimental approaches that might be applicable to your readings. We follow the principles of the flipped classroom in this course. Please read the recommended material prior to class. D. Evaluation 30% classroom participation/assignments/readiness quizzes 30% mid‐course written assignment 40% final written assignment Grading Scale: 86 – 100% = A 71 – 85% = B 70 or below = C E. Required textbook Kindt TJ, RA Goldsby, BA Osborne, Kuby Immunology, 6th edition, WH Freeman, New York, 2007 OR Owen, J, J Punt and S Stanford, Kuby Immunology, 7th edition, WH Freman, New York, 2013 F. Classroom sessions We will not have formal lectures (unless you students want to give them). Rather, I would ask that you read the assigned textbook readings and simply prepare a list of 5‐6 overarching principles that you derived from the readings assigned for that day. For example, after reading the first chapter, you might find that a definition of immunity would be a good general principle. I will also provide you with a list of discussion questions prior to each class meeting, so that you can begin to consider the significance of your readings as you are going through them. When we meet, we will go through exercises constructed around this material, answer questions you might have and consider some of the ways in which immunologists experimentally study the material addressed by the readings. You should always be prepared for a “readiness quiz,” an exercise that may count towards your grade that tests your preparation for discussing the material assigned for each class day. G. Blackboard Network Learning Site A site for the course will be established on Blackboard (https://bb.kumc.edu/) . Once you have been registered as a student for this site, you will be able to find general class announcements, assignments and other materials. Please bring a personal computer to class. H. Our First Meeting As you may have noticed by the schedule, you have a reading assignment for our first meeting, which is already posted on the Blackboard course site. This includes relevant discussion points we will review during this session. Call or drop me an email if you cannot access the material on Blackboard.