Project Description
P09052
Molecular Imaging System Upgrade
I. ADMINISTRATIVE INFORMATION
Project Title:
Development of a novel 3-D optical molecular imaging system prototype and
calibration methods
Company 1 Name
Carestream Health Inc.
Company 1 Contact:
Gilbert D. Feke, Ph.D.
Phone and E-mail
203-786-5638, gilbert.feke@carestreamhealth.com
Postal Address
4 Science Park West, New Haven CT 06511
Company 2 Name
Qioptiq Imaging Solutions Inc.
Company 2 Contact:
Linda Antos
Phone and E-mail
585-223-2370 x148, Linda.Antos@ny.qioptiq.com
Postal Address
78 Schuyler Baldwin Drive, Rochester, NY 14450
PI Name:
Maria Helguera, Ph.D.
PI Phone and E-mail
585-475-7053, helguera@cis.rit.edu
Postal Address
RIT, Center for Imaging Science
54 Lomb Memorial Drive, Rochester, NY 14623
Co-Investigators Names: Richard Doolittle, Ph.D, Daniel Phillips, Ph.D.
7 March 2016
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Project Description
P09052
Molecular Imaging System Upgrade
II. PROJECT DESCRIPTION
a.
Project Title
Development of a novel 3-D optical molecular imaging system prototype and calibration
method.
b.
Project Abstract
A currently available 2-D high-resolution, optical molecular imaging system will be
modified by the addition of a structured illumination source to investigate the feasibility
of providing depth resolution along the optical axis. The modification includes additional
optics as well as control and signal processing software. The objective of this effort is to
evaluate the possibility of providing low-cost, non-invasive, functional imaging in three
dimensions. In addition to the proposed system modifications, a calibration device will
also be developed to test the capabilities of the system in terms of range and resolution.
c.
Project Duration
It is anticipated that the modifications and calibration development can be carried out in
parallel over a roughly six month period that includes testing and validation phases. If
validation efforts prove successful, it is possible that another three months would be spent
in more exhaustive evaluation as well as development of more sophisticated calibration
devices.
d.
Science and Technology
Problem:
Carestream Health, Inc., has a need for a research prototype of a clinical system capable
of performing depth-resolved optical molecular imaging of a stationary human hand,
specifically fluorescence imaging.
Carestream Health, Inc., and Qioptiq Imaging Solutions, Inc. of Rochester, NY have a
desire to explore the application of Qioptiq’s “structured illumination” solution for depthresolution (commercially vended under the name Optigrid) to the problem, as well as the
integration of structured illumination technology into Carestream Health, Inc.’s
molecular imaging system platform (commercially vended under the name KODAK In
Vivo Imaging System F).
Carestream Health, Inc.’s existing imaging platform is currently not capable of singlewavelength depth-resolved optical molecular imaging of stationary subjects. Approaches
involving structured illumination have been demonstrated by others to solve the problem
(for example, see US Patent Appl. No. 2006/0184043 by Tromberg et al., applied to a
7 March 2016
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Project Description
P09052
Molecular Imaging System Upgrade
mouse), so the application of structured illumination to the problem is what Carestream
Health, Inc., needs to research.
The initial demonstration of the working research prototype needs to include depth
discrimination between fluorescence signals originating from the front of the hand vs. the
back of the hand, with special attention paid to the major joint structures at
metacarpophalangeal and interphalangeal articulations, whereby the fluorescence signals
have the same wavelength (i.e., so that discrimination by color is not available). Such a
demonstration would likely involve application of small pieces of commercially available
fluorescent plastic sheets to volunteer hands. If possible, a follow-up demonstration
should include depth discrimination of the interior of fluorescently-labeled joints of a
phantom (i.e., model) hand, whereby the phantom hand shall be developed by RIT.
Hence, the problem is two-fold – modification of Carestream’s imaging platform to
provide this capability and development of suitable calibration device to assess the
efficacy relative to the stated goal of depth-resolved imaging of a stationary human hand
by the modified system.
Objectives:
Engage a multidisciplinary team to:
-
Implement and test the envisioned prototype system
Develop a suitable calibration device and quantitative assessment methodology
Investigate the methods necessary to develop a suitable anthropomorphic test
device based on the anatomy of a human hand
Methodology:
The three objectives can be carried out essentially in parallel and be utilized in an
interactive fashion to validate established or suggested development milestones. For
example, investigation of human hand anatomy scattering properties could be used to
establish parameters of a calibration device that could be utilized to assess preliminary
operation of the optical components and light source of the prototype system.
-
Implementation and testing of prototype system
The Qioptiq structured illumination system will be integrated with the current
KODAK F series system light source. Optical components necessary to provide
depth-resolved imaging will be integrated as well. Control electronics, embedded
software and application software to be run on a PC platform will be developed.
The modified system will be tested in terms of basic functionality.
-
Calibration device and testing methodology
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Project Description
P09052
Molecular Imaging System Upgrade
A simple geometric test object will be developed that incorporates fluorescent
target material(s) at specified depths suitable to assess range, resolution and
sensitivity of the desired prototype as well as being representative of features
associated with the material properties and spatial organization of a human hand,
both of normal and a defined set of pathological circumstances.
-
Investigation of methods necessary to produce an anthropomorphic calibration
device based on the properties of a human hand
Based on known properties of the anatomy and material composition of the
human hand in normal and a defined set of pathological circumstances (e.g.,
rheumatoid arthritis, osteoarthritis) as well as the desired imaging capabilities of
the prototype imaging system, methods of fabrication will be investigated. The
methods will be assessed for feasibility, accuracy, repeatability, and flexibility. It
is expected that prototype testing of candidate methods and materials will be
evaluated and executed using standardized equipment as well as the prototype
system as it becomes available.
As sponsors, both Carestream Health, Inc., and Qioptiq will participate in at most one to
two hour biweekly design and project reviews. Qioptiq shall provide advice for
implementation of structured illumination technology, as well as materials including a
standard grid as used for defining the structured illumination pattern, a paddle for
interfacing the grid to the actuation mechanism, the actuation mechanism, and the control
electronics. Carestream Health, Inc., shall provide advice for integration of structured
illumination technology into Carestream Health, Inc.’s existing imaging platform and
procedures to achieve the demonstrations, as well as materials including the critical
components of the existing imaging platform, additional materials necessary to integrate
the materials provided by Qioptiq into the existing imaging platform (where available),
and funds for purchase and manufacture of parts (when necessary).
Alternatives:
Modification of the KODAK F series system represents a rather unique task, although
alternative illumination sources and optical systems are certainly feasible, whether or not
they would result in a more expeditious effort. Other, more customized optical solutions
may provide more optimal results but would probably lengthen development time and
add additional variables in terms of assessing the functionality of the system.
In terms of calibration devices, it is possible that other calibration devices and methods
associated with other imaging and calibration methods may already exist or may be easily
modified to suit this particular application. If so, that would allow additional allocation
of efforts for other aspects of the project.
Based on the known properties and spatial composition of the human hand, it might be
possible to utilize currently available physical hand models or even a suitably fixed
cadaver hand to provide the necessary testing and validation of the proposed system.
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Project Description
P09052
Molecular Imaging System Upgrade
Deliverables:
- Operational prototype consisting of modified KODAK F molecular imaging system
including software, full documentation, testing and validation results.
- Characterized calibration device, devices or system including software, algorithms, full
documentation and test results.
- Documentation consisting of report, notes, preliminary prototypes regarding
construction methodology for producing, testing and validating an anthropomorphic hand
model to evaluate depth-resolvable molecular imaging capabilities of modified KODAK
F molecular imaging system.
e.
Technology Transfer
The principal investigator will be in regular contact with RIT collaborators and have the
right to retain all materials as a result of the effort of study participants. All investigators
will maintain dated lab notebooks and maintain electronic information in the form of
reports, simulations, data, analyses and the like in a version controlled electronic
repository with access-controlled internet availability to designated individuals. Periodic
project progress reviews will be conducted that will include reports in both electronic and
printed form. Relevant intellectual property policies of all participants and their
sponsoring institutions and employers will be negotiated, detailed and agreed upon prior
to the beginning of study efforts.
III. PROJECT DELIVERABLES (One or two-sentence descriptions.)
Project Deliverable No. 1
Modified imaging system and supporting
documentation.
Due Date for Deliverable No. 1 May 30, 2009
Project Deliverable No. 2
Calibration device(s), system and supporting
documentation.
Due Date for Deliverable No. 2 May 30, 2009
Project Deliverable No. 3
Due Date for Deliverable No. 3
7 March 2016
Results of method necessary to produce
anthropomorphic hand model for system testing and
supporting documentation and artifacts.
May 30, 2009
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